Patents by Inventor Christine C. Dykstra

Christine C. Dykstra has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds, methods and compositions useful for the treatment of bovine viral diarrhea virus (BVDV) infection and hepatitis C virus (HCV) infection
    Patent number: 7410999
    Abstract: The present invention relates to novel compounds and methods that are useful in treating members of the Flaviviridae family of viruses. Compounds of the present invention will have a structure according to Formulas (I)-(VI) as recited throughout the application.
    Type: Grant
    Filed: November 20, 2006
    Date of Patent: August 12, 2008
    Assignees: University of North Carolinia at Chapel Hill, Georgia State University Research Foundation, Inc., Auburn University
    Inventors: Christine C. Dykstra, Maurice Daniel Givens, David A. Stringfellow, Kenny Brock, David Boykin, Arvid Kumar, W. David Wilson, Richard R. Tidwell, Chad F. Stephens
  • Compounds, methods and compositions useful for the treatment of bovine viral diarrhea virus (BVDV) infection and hepatitis C virus (HCV) infection
    Patent number: 7410989
    Abstract: The present invention relates to novel compounds and methods that are useful in treating members of the Flaviviridae family of viruses. Compounds of the present invention will have a structure according to Formulas (I)-(VI) as recited throughout the application.
    Type: Grant
    Filed: November 20, 2006
    Date of Patent: August 12, 2008
    Assignees: The University of North Carolina at Chapel Hill, Georgia State University Research Foundation, Inc., Auburn University
    Inventors: Christine C. Dykstra, Maurice Daniel Givens, David A. Stringfellow, Kenny Brock, David Boykin, Arvid Kumar, W. David Wilson, Richard R. Tidwell, Chad F. Stephens
  • Compounds, methods and compositions useful for the treatment of bovine viral diarrhea virus (BVDV) infection and hepatitis C virus (HCV) infection
    Patent number: 7183286
    Abstract: The present invention relates to novel compounds and methods that are useful in treating members of the Flaviviridae family of viruses. Compounds of the present invention will have a structure according to Formulas (I)–(VI) as recited throughout the application.
    Type: Grant
    Filed: March 9, 2004
    Date of Patent: February 27, 2007
    Assignees: The University of North Carolina at Chapel Hill, Auburn University, Georgia State University Research Foundation, Inc.
    Inventors: Christine C. Dykstra, Maurice Daniel Givens, David A. Stringfellow, Kenny Brock, David W. Boykin, Arvid Kumar, W. David Wilson, Richard R. Tidwell, Chad F. Stephens
  • Compounds, methods and compositions useful for the treatment of bovine viral diarrhea virus (BVDV) infection and hepatitis C virus (HCV) infection
    Patent number: 7163955
    Abstract: The present invention relates to novel compounds and methods that are useful in treating members of the Flaviviridae family of viruses. Compounds of the present invention will have a structure according to Formulas (I)–(VI) as recited throughout the application.
    Type: Grant
    Filed: October 28, 2005
    Date of Patent: January 16, 2007
    Assignees: The University of North Carolina at Chapel Hill, Georgia State University Research Foundation, Inc., Auburn University
    Inventors: Christine C. Dykstra, Maurice Daniel Givens, David A. Stringfellow, Kenny Brock, David Boykin, Arvid Kumar, W. David Wilson, Richard R. Tidwell, Chad F. Stephens
  • Method of inhibiting retroviral integrase
    Patent number: 6815461
    Abstract: Disclosed is a method of inhibiting retroviral integrase in a subject in need of such treatment. The method comprises administering to the subject an effective retroviral integrase inhibiting amount of a bis-benzimidazole compound such as bis[5-amidino-2-benzimidazolyl]methane, 1,2-bis[5-amidino-2-benzimidazolyl]ethane, 1,2-bis[5-amidino-2-benzimidazolyl]ethene or a pharmaceutically acceptable salt thereof. A method for combatting retroviral infections is also disclosed.
    Type: Grant
    Filed: January 20, 1994
    Date of Patent: November 9, 2004
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Christine C. Dykstra, Ronald I. Swanstrom, Richard R. Tidwell
  • Methods and formulations for the treatment of infectious bursal disease in avian subjects
    Patent number: 6774144
    Abstract: In one aspect, the invention relates to a method of treating infectious bursal disease (IBD) in an avian subject in need of such treatment. The method comprises administering to the subject a compound of the formulas (I) through (IV) or a pharmaceutically acceptable salt thereof in an amount sufficient to treat IBD. In another aspect, the invention relates to a method of producing active immunity against infectious bursal virus disease (IBD) in an avian subject. The method comprises administering to a subject an immunogenic-amount of an IBDV vaccine and a compound selected from the compounds of formulas (I) through (IV) described herein. The compound represented by formulas (I) through (IV) is administered in an amount sufficient to induce an immune response in the avian subject.
    Type: Grant
    Filed: November 1, 2000
    Date of Patent: August 10, 2004
    Assignees: The University of North Carolina at Chapel Hill, Georgia State University Research Foundation, Inc., Auburn University
    Inventors: Christine C. Dykstra, James C. Hudson, Sandra Ewald, Richard R. Tidwell, David W. Boykin
  • Compounds, methods and compositions useful for the treatment of bovine viral diarrhea virus (BVDV) infection and hepatitis C virus (HCV) infection
    Publication number: 20030199521
    Abstract: The present invention relates to novel compounds and methods that are useful in treating members of the Flaviviridae family of viruses. Compounds of the present invention will have a structure according to Formulas (I)-(VI) as recited throughout the application.
    Type: Application
    Filed: January 11, 2002
    Publication date: October 23, 2003
    Inventors: Christine C. Dykstra, Maurice Daniel Givens, David A. Stringfellow, Kenny Brock, David Boykin, Arvind Kumar, W. David Wilson, Richard R. Tidwell, Chad E. Stephens
  • Methods of combatting infectious diseases using dicationic bis-benzimidazoles
    Patent number: 6294565
    Abstract: The present invention provides methods for treating Crytococcus neoformans and Candida albicans in a subject in need of such treatment. The methods comprises administering to the subject a dicationic bis-benzimidazole in an amount effective to treat the conditions.
    Type: Grant
    Filed: April 6, 2000
    Date of Patent: September 25, 2001
    Assignees: University of North Carolina at Chapel Hill, Duke University, Georgia State University Research Foundation
    Inventors: Christine C. Dykstra, John Perfect, David W. Boykin, W. David Wilson, Richard R. Tidwell
  • Methods of combating infectious diseases using dicatoni bis-benzimidazoles
    Patent number: 6156779
    Abstract: The present invention provides methods for treating Cryptococcus neoformans and Candida albicans in a subject in need of such treatment. The methods comprises administering to the subject a dicationic bis-benzimidazole in an amount effective to treat the conditions.
    Type: Grant
    Filed: January 4, 2000
    Date of Patent: December 5, 2000
    Assignees: University of North Carolina at Chapel Hill, Duke University, Georgia State University Research Foundation
    Inventors: Christine C. Dykstra, John Perfect, David W. Boykin, W. David Wilson, Richard R. Tidwell
  • Methods of combatting infectious diseases using dicationic bis-benzimidazoles
    Patent number: 6046226
    Abstract: The present invention provides methods for treating Cryptococcus neoformans and Candida albicans in a subject in need of such treatment. The methods comprises administering to the subject a dicationic bis-benzimidazole in an amount effective to treat the conditions.
    Type: Grant
    Filed: July 13, 1999
    Date of Patent: April 4, 2000
    Assignees: University of North Carolina at Chapel Hill, Georgia State University Research Foundation, Duke University
    Inventors: Christine C. Dykstra, John Perfect, David W. Boykin, W. David Wilson, Richard R. Tidwell
  • Method of combatting infectious diseases using dicationic bis-benzimidazoles
    Patent number: 6017941
    Abstract: The present invention provides methods for treating Cryptococcus neoformans and Candida albicans in a subject in need of such treatment. The methods comprises administering to the subject a dicationic bis-benzimidazole in an amount effective to treat the conditions.
    Type: Grant
    Filed: September 1, 1998
    Date of Patent: January 25, 2000
    Assignees: The University of North Carolina at Chapel Hill, Duke University, Georgia State University Research Foundation
    Inventors: Christine C. Dykstra, John Perfect, David W. Boykin, W. David Wilson, Richard R. Tidwell
  • Methods of combatting infectious disease using dicationic bis-benzimidazoles
    Patent number: 5972969
    Abstract: The present invention provides methods for treating Cryptococcus neoformans and Candida albicans in a subject in need of such treatment. The methods comprises administering to the subject a dicationic bis-benzimidazole in an amount effective to treat the conditions.
    Type: Grant
    Filed: September 1, 1998
    Date of Patent: October 26, 1999
    Assignees: The University of North Carolina at Chapel Hill, Duke University, Gerogia State University Research Foundation, Inc.
    Inventors: Christine C. Dykstra, John Perfect, David W. Boykin, W. David Wilson, Richard R. Tidwell
  • Methods of combatting infectious diseases using dicationic bis-benzimidazoles
    Patent number: 5939440
    Abstract: The present invention provides methods for treating Cryptococcus neoformans and Candida albicans in a subject in need of such treatment. The methods comprises administering to the subject a dicationic bis-benzimidazole in an amount effective to treat the conditions.
    Type: Grant
    Filed: August 7, 1998
    Date of Patent: August 17, 1999
    Assignees: The University of North Carolina at Chapel Hill, Duke University, Georgia State University Research Foundation, Inc.
    Inventors: Christine C. Dykstra, John Perfect, David W. Boykin, W. David Wilson, Richard R. Tidwell
  • Methods of treating retroviral infection and compounds useful therefor
    Patent number: 5935982
    Abstract: The present invention provides methods for treating retroviral infection and methods of treating HIV infection. The methods of the present invention include administering compounds of the general Formula I: ##STR1## wherein L, R.sub.1, R.sub.2, R.sub.3, R.sub.4 are defined herein.
    Type: Grant
    Filed: February 28, 1997
    Date of Patent: August 10, 1999
    Assignees: The University of North Carolina at Chapel Hill, Auburn University, Georgia State Research Foundation, Inc.
    Inventors: Christine C. Dykstra, David Boykin, Richard R. Tidwell
  • Method of combatting infectious diseases using dicatonic bis-benzimidazoles
    Patent number: 5817687
    Abstract: The present invention provides methods for treating Cryptococcus neoformans and Candida albicans in a subject in need of such treatment. The methods comprises administering to the subject a dicationic bis-benzimidazole in an amount effective to treat the conditions.
    Type: Grant
    Filed: May 29, 1997
    Date of Patent: October 6, 1998
    Assignees: The University of North Carolina at Chapel Hill, Duke University, Georgia State University Research Foundation
    Inventors: Christine C. Dykstra, John Perfect, David W. Boykin, W. David Wilson, Richard R. Tidwell
  • Methods of combatting infectious diseases using dicationic bis-benzimidazoles
    Patent number: 5817686
    Abstract: The present invention provides methods for treating Cryptococcus neoformans and Candida albicans in a subject in need of such treatment. The methods comprises administering to the subject a dicationic bis-benzimidazole in an amount effective to treat the conditions.
    Type: Grant
    Filed: May 29, 1997
    Date of Patent: October 6, 1998
    Assignees: University of North Carolina at Chapel Hill, Duke University, Georgia State
    Inventors: Christine C. Dykstra, John Perfect, David W. Boykin, W. David Wilson, Richard R. Tidwell
  • Methods of combatting infectious diseases using dicationic bis-benzimidazoles
    Patent number: 5792782
    Abstract: The present invention provides methods for treating Cryptococcus neoformans and Candida albicans in a subject in need of such treatment. The methods comprises administering to the subject a dicationic bis-benzimidazole in an amount effective to treat the conditions.
    Type: Grant
    Filed: May 29, 1997
    Date of Patent: August 11, 1998
    Assignees: The University of North Carolina at Chapel Hill, Duke University, Georgia State University Research Foundation, Inc.
    Inventors: Christine C. Dykstra, John Perfect, David W. Boykin, W. David Wilson, Richard R. Tidwell
  • Method of fluorescent detection of nucleic acids and cytoskeleton elements using bis-dicationic aryl furans, and kits useful therefor
    Patent number: 5723288
    Abstract: Disclosed is a method of fluorescent detection of a nucleic acid. The method comprises contacting to the nucleic acid a bis-dicationic aryl furan compound, such as 2,5-bis?4-(4,5,6,7-tetrahydro-1H-1,3-diazepin-2-yl) phenyl! furan; 2,5-bis{?4-(N-isopropyl) amidino! phenyl}furan; and physiologically acceptable salts thereof, and exposing the nucleic acid to light at a frequency to induce fluorescence of the compound. A method for fluorescent detection of cytoskeleton elements, and novel bis-dicationic aryl furan compounds are also disclosed.
    Type: Grant
    Filed: May 6, 1994
    Date of Patent: March 3, 1998
    Assignees: The University of North Carolina at Chapel Hill, Georgia State University Research Foundation, Inc.
    Inventors: Christine C. Dykstra, Richard R. Tidwell, David W. Boykin, W. David Wilson, Jaroslaw Spychala, Bijan P. Das, Arvind Kumar
  • Methods of treating pneumocystis carinii pneumonia
    Patent number: 5686456
    Abstract: The present invention provides methods for treating Pneumocystis carinii pneumonia in a subject in need of such treatment. The methods comprise administering to a subject in need thereof, a pyrimidine of Formula I. ##STR1## wherein the variables are as defined in the specification.
    Type: Grant
    Filed: November 28, 1995
    Date of Patent: November 11, 1997
    Assignees: The University of North Carolina, Georgia State University Research Foundation, Inc., Auburn University
    Inventors: David W. Boykin, Christine C. Dykstra, Richard R. Tidwell, James E. Hall, W. David Wilson, Arvind Kumar
  • Method of fluorescent detection of nucleic acids and cytoskeleton elements using bis-dicationic aryl furans
    Patent number: 5667975
    Abstract: Disclosed is a method of fluorescent detection of a nucleic acid. The method comprises contacting to the nucleic acid a bis-dicationic aryl furan and exposing the nucleic acid to light at a frequency to induce fluorescence of the compound. A method for fluorescent detection of cytoskeleton elements, and novel bis-dicationic aryl furan compounds are also disclosed.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: September 16, 1997
    Assignee: The University of North Carolina
    Inventors: Christine C. Dykstra, Richard R. Tidwell, David W. Boykin, W. David Wilson