Patents by Inventor Christine C. Hudson

Christine C. Hudson has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Constitutively Translocating Cell Line
    Publication number: 20090081652
    Abstract: The present invention relates to agonist-independent methods of screening for compounds that alter GPCR desensitization. Included in the present invention are cell lines containing GRKs, in which GPCRs are desensitized in the absence of agonist; the GRKs may be modified. The present invention relates to methods to determine if a GPCR is expressed at the plasma membrane, and if the GPCR has an affinity for arrestin. Modified GPCRs which have increased arrestin affinity are included in the present invention. These modified GPCRs are useful in methods to screen for compounds that alter desensitization, including both the agonist-independent methods and agonist-dependent methods described herein.
    Type: Application
    Filed: November 8, 2007
    Publication date: March 26, 2009
    Applicant: Molecular Devices Corporation
    Inventors: Robert H. Oakley, Christine C. Hudson
  • CONSTITUTIVELY TRANSLOCATING CELL LINE
    Publication number: 20090082410
    Abstract: The present invention relates to agonist-independent methods of screening for compounds that alter GPCR desensitization. Included in the present invention are cell lines containing GRKs, in which GPCRs are desensitized in the absence of agonist; the GRKs may be modified. The present invention relates to methods to determine if a GPCR is expressed at the plasma membrane, and if the GPCR has an affinity for arrestin. Modified GPCRs which have increased arrestin affinity are included in the present invention. These modified GPCRs are useful in methods to screen for compounds that alter desensitization, including both the agonist-independent methods and agonist-dependent methods described herein.
    Type: Application
    Filed: November 8, 2007
    Publication date: March 26, 2009
    Applicant: Molecular Devices Corporation
    Inventors: Robert H. Oakley, Christine C. Hudson
  • Constitutively translocating cell line
    Patent number: 7332292
    Abstract: The present invention relates to agonist-independent methods of screening for compounds that alter GPCR desensitization. Included in the present invention are cell lines containing GRKs, in which GPCRs are desensitized in the absence of agonist; the GRKs may be modified. The present invention relates to methods to determine if a GPCR is expressed at the plasma membrane, and if the GPCR has an affinity for arrestin. Modified GPCRs which have increased arrestin affinity are included in the present invention. These modified GPCRs are useful in methods to screen for compounds that alter desensitization, including both the agonist-independent methods and agonist-dependent methods described herein.
    Type: Grant
    Filed: February 26, 2004
    Date of Patent: February 19, 2008
    Assignee: Molecular Devices Corporation
    Inventors: Robert H. Oakley, Christine C. Hudson