Patents by Inventor Christine Canman

Christine Canman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • ATM kinase modulation for screening and therapies
    Publication number: 20030022263
    Abstract: The present invention relates to identification of the consensus sequence phosphorylated by ATM kinase. This, in turn, permitted identification of ATM kinase target proteins, and development of a convenient assay system for ATM kinase phosphorylation using fusion polypeptides as substrates. The assay system is adaptable to screening for ATM modulators, particularly inhibitors. In a specific embodiment, the substrate recognition sequence and mutagenized variants of this sequence were incorporated in a GST fusion protein and assayed for phosphorylation by ATM kinase. This assay system is useful in screening for ATM inhibitors. ATM function assays were validated using an ATM-kinase dead dominant-negative mutant.
    Type: Application
    Filed: December 17, 2001
    Publication date: January 30, 2003
    Applicant: ST. JUDE CHILDREN'S RESEARCH HOSPITAL
    Inventors: Michael Kastan, Christine Canman, Seong-Tae Kim, Dae-Sik Lim
  • ATM kinase modulation for screening and therapies
    Patent number: 6387640
    Abstract: The present invention relates to identification of the consensus sequence phosphorylated by ATM kinase. This, in turn, permitted identification of ATM kinase target proteins, and development of a convenient assay system for ATM kinase phosphorylation using fusion polypeptides as substrates. The assay system is adaptable to screening for ATM modulators, particularly inhibitors. In a specific embodiment, the substrate recognition sequence and mutagenized variants of this sequence were incorporated in a GST fusion protein and assayed for phosphorylation by ATM kinase. This assay system is useful in screening for ATM inhibitors. ATM function assays were validated using an ATM-kinase dead dominant-negative mutant.
    Type: Grant
    Filed: February 10, 1999
    Date of Patent: May 14, 2002
    Assignees: St. Jude Children's Research Hospital, Johns-Hopkins University
    Inventors: Michael Kastan, Christine Canman, Seong-Tae Kim, Dae-Sik Lim
  • ATM kinase modulation for screening and therapies
    Patent number: 6348311
    Abstract: The present invention relates to identification of the consensus sequence phosphorylated by ATM kinase. This, in turn, permitted identification of ATM kinase target proteins, and development of a convenient assay system for ATM kinase phosphorylation using fusion polypeptides as substrates. The assay system is adaptable to screening for ATM modulators, particularly inhibitors. In a specific embodiment, the substrate recognition sequence and mutagenized variants of this sequence were incorporated in a GST fusion protein and assayed for phosphorylation by ATM kinase. This assay system is useful in screening for ATM inhibitors. ATM function assays were validated using an ATM-kinase dead dominant-negative mutant.
    Type: Grant
    Filed: September 21, 1999
    Date of Patent: February 19, 2002
    Assignees: St. Jude Childre's Research Hospital, Johns-Hopkins University
    Inventors: Michael Kastan, Christine Canman, Seong-Tae Kim, Dae-Sik Lim