Patents by Inventor Christine Debouck

Christine Debouck has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods for Identifying Genes Essential to the Growth of an Organism
    Publication number: 20080076672
    Abstract: The present invention provides methods for identifying genes essential to the growth of an organism using a grid prepared from a genomic library of a selected organism. Genes identified as essential by this method and proteins encoded thereby are also provided. In addition, methods of using these genes and proteins encoded thereby are disclosed.
    Type: Application
    Filed: July 9, 2007
    Publication date: March 27, 2008
    Inventors: Christine Debouck, Jeffrey MOONEY
  • Peptidyl t-RNA hydrolase (PTH)
    Patent number: 7202071
    Abstract: The invention provides pth polypeptides and polynucleotides encoding pth polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pth polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: May 14, 2003
    Date of Patent: April 10, 2007
    Assignee: SmithKline Beecham Corporation
    Inventors: Sanjoy Biswas, James Raymond Brown, Christine Debouck, Deborah Dee Jaworski, Elizabeth Jane Lawlor, Jeffrey Mooney, Lisa Kathleen Shilling, Min Wang, Richard Lloyd Warren, Magdalena Zalacain, Yi Yi Zhong, John Peter Throup, Karen Anne Ingraham, Alison Frances Chalker, David John Holmes, Christopher Michael Traini
  • FabH
    Patent number: 6682919
    Abstract: The invention provides FabH polypeptides and polynucleotides encoding FabH polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing FabH polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: November 14, 1997
    Date of Patent: January 27, 2004
    Assignee: SmithKline Beecham Corporation
    Inventors: Christine Debouck, Daniel Robert Gentry, Deborah Dee Jaworski, John Timothy Londsdale, Jeffrey L Mooney, David John Payne, Stewart Campbell Pearson, Lisa Kathleen Schilling, Glenn Scott Van Aller, Min Wang, Yi Yi Zhong
  • Novel pth
    Publication number: 20030232373
    Abstract: The invention provides pth polypeptides and polynucleotides encoding pth polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pth polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: May 14, 2003
    Publication date: December 18, 2003
    Applicant: SmithKline Beecham Corporation
    Inventors: Sanjoy Biswas, James Raymond Brown, Christine Debouck, Deborah Dee Jaworski, Elizabeth Jane Lawlor, Jeffrey Mooney, Lisa Kathleen Shilling, Min Wang, Richard Lloyd Warren, Magdalena Zalacain, Yi Yi Zhong, John Peter Throup, Karen Anne Ingraham, Alison Frances Chalker, David John Holmes, Christopher Michael Traini
  • Novel pth
    Publication number: 20020058799
    Abstract: The invention provides pth polypeptides and polynucleotides encoding pth polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pth polypeptides to screen for antibacterial compounds.
    Type: Application
    Filed: May 2, 2001
    Publication date: May 16, 2002
    Inventors: Sanjoy Biswas, James Raymond Brown, Christine Debouck, Deborah Dee Jaworski, Elizabeth Jane Lawlor, Jeffrey Mooney, Lisa Kathleen Shilling, Min Wang, Richard Lloyd Warren, Magdalena Zalacain, Yi Yi Zhong, John Peter Throup, Karen Anne Ingraham, Alison Frances Chalker, David John Holmes, Christopher Michael Traini
  • Nucleic acids encoding Streptococcus pneumoniae FabG
    Patent number: 6346395
    Abstract: The invention provides FabG polypeptides and polynucleotides encoding FabG polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing FabG polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: January 27, 1999
    Date of Patent: February 12, 2002
    Assignee: SmithKline Beecham Corp.
    Inventors: Alison Francis Chalker, Christine Debouck, David John Holmes, Karen Anne Ingraham, Deborah Dee Jaworski, Anna Lisa Kosmatka, Damien McDevitt, Jeffrey Mooney, Stewart C Pearson, Chi Yong So, Nicola Gail Wallis, Min Wang, Richard Lloyd Warren, Yi Yi Zhong
  • ribG
    Patent number: 6335424
    Abstract: The invention provides ribG polypeptides and polynucleotides encoding ribG polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribG polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: November 25, 1997
    Date of Patent: January 1, 2002
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham PLC
    Inventors: Michael Terence Black, Christine Debouck, Jason Craig Fedon, John Edward Hodgson, Deborah Dee Jaworski, David Justin Charles Knowles, Anna Lisa Kosmatka, Jeffrey Mooney, Richard Oakley Nicholas, Leslie Marie Palmer, Lisa Kathleen Shilling, Robert King Stodola, Min Wang, Richard Lloyd Warren, Yi Yi Zhong
  • RibH
    Patent number: 6326462
    Abstract: The invention provides ribH polypeptides and polynucleotides encoding ribH polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribH polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: January 27, 2000
    Date of Patent: December 4, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Christine Debouck, Jason Craig Fedon, Deborah Dee Jaworski, Jeffrey Mooney, Leslie Marie Palmer, Christopher Michael Traini, Min Wang, Richard Lloyd Warren, Yi Yi Zhong
  • Pth
    Patent number: 6303771
    Abstract: The invention provides pth polypeptides and polynucleotides encoding pth polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing pth polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: May 18, 1998
    Date of Patent: October 16, 2001
    Assignee: SmithKline Beecham Corporation
    Inventors: Sanjoy Biswas, James Raymond Brown, Christine Debouck, Deborah Dee Jaworski, Elizabeth Jane Lawlor, Jeffrey Mooney, Lisa Kathleen Shilling, Min Wang, Richard Lloyd Warren, Magdalena Zalacain, Yi Yi Zhong, John Peter Throup, Karen Anne Ingraham, Alison Frances Chalker, David John Holmes, Christopher Michael Traini
  • Polynucleotides encoding GTP cyclohydrolase II (RIBA)
    Patent number: 6280971
    Abstract: The invention provides ribA polypeptides and polynucleotides encoding ribA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribA polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: January 11, 1999
    Date of Patent: August 28, 2001
    Assignees: SmithKline Beecham Corporatiion, SmithKline Beecham plc
    Inventors: Min Wang, Judith M Ward, Richard Lloyd Warren, Richard Oakley Nicholas, Leslie Marie Palmer, Julie M Pratt, David Justin Charles Knowles, Michael Arthur Lonetto, Jeffrey Mooney, Michael Terence Black, Martin Karl Russell Burnham, Christine Debouck, Jason Craig Fedon, John Edward Hodgson, Deborah Dee Jaworski, Raymond Winfield Reichard, Martin Rosenberg, Christopher Michael Traini, Yi Y Zhong
  • GlmU
    Patent number: 6204042
    Abstract: The invention provides GlmU polypeptides and polynucleotides encoding GlmU polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing GlmU polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: May 10, 1999
    Date of Patent: March 20, 2001
    Assignee: SMithKline Beecham Corporation
    Inventors: Christine Debouck, Deborah Dee Jaworski, Jeffrey L Mooney, Lisa Kathleen Shilling, Nicola Gail Wallis, Min Wang, Yi Yi Zhong
  • GTP cyclohydrolase II (RIBA)
    Patent number: 6171598
    Abstract: The invention provides ribA polypeptides and polynucleotides encoding ribA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribA polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: January 6, 1999
    Date of Patent: January 9, 2001
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham plc
    Inventors: Min Wang, Judith M Ward, Richard Lloyd Warren, Richard Oakley Nicholas, Leslie Marie Palmer, Julie M Pratt, David Justin Charles Knowles, Michael Arthur Lonetto, Jeffrey Mooney, Michael Terence Black, Martin Karl Russell Burnham, Christine Debouck, Jason Craig Fedon, John Edward Hodgson, Deborah Dee Jaworski, Raymond Winfield Reichard, Martin Rosenberg, Christopher Michael Traini, Yi Yi Zhong
  • DNA encoding streptococcus pneumoniae trigger factor polypeptides
    Patent number: 6100069
    Abstract: The invention provides tig polypeptides and polynucleotides encoding tig polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing tig polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: November 20, 1998
    Date of Patent: August 8, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: Sanjoy Biswas, James Raymond Brown, Christine Debouck, Deborah Dee Jaworski, Elizabeth Jane Lawlor, Jeffrey Mooney, Lisa Kathleen Katz, Min Wang, Richard Lloyd Warren, Magdalena Zalacain, Yi Yi Zhong
  • GlmU
    Patent number: 6043071
    Abstract: The invention provides GlmU polypeptides and polynucleotides encoding GlmU polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing GlmU polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: November 17, 1997
    Date of Patent: March 28, 2000
    Assignee: SmithKline Beecham Corporation
    Inventors: Christine DeBouck, Deborah Dee Jaworski, Jeffrey L Mooney, Lisa Kathleen Shilling, Nicola Gail Wallis, Min Wang, Yi Yi Zhong
  • Polynucleotides encoding GTP cyclohydrolase II (ribA)
    Patent number: 5891672
    Abstract: The invention provides ribA polypeptides and polynucleotides encoding ribA polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing ribA polypeptides to screen for antibacterial compounds.
    Type: Grant
    Filed: November 25, 1997
    Date of Patent: April 6, 1999
    Assignees: SmithKline Beecham Corporation, SmithKline Beecham p.l.c.
    Inventors: Min Wang, Judith M Ward, Richard Lloyd Warren, Richard Oakley Nicholas, Leslie Marie Palmer, Julie M Pratt, David Justin Charles Knowles, Michael Arthur Lonetto, Jeffrey Mooney, Michael Terence Black, Martin Karl Russell Burnham, Christine Debouck, Jason Craig Fedon, John Edward Hodgson, Deborah Dee Jaworski, Raymond Winfield Reichard, Martin Rosenberg, Christopher Michael Traini, Yi Yi Zhong
  • Human ETS family member, ELF3
    Patent number: 5789200
    Abstract: Human ELF3 polypeptides and DNA (RNA) encoding such ELF3 and a procedure for producing such polypeptides by recombinant techniques is disclosed. Also disclosed are methods for utilizing such ELF3 for the diagnosis and treatment of cancers, in particular prostate, breast, lung or other epithelial tumors, among others.
    Type: Grant
    Filed: November 15, 1996
    Date of Patent: August 4, 1998
    Assignees: SmithKline Beecham Corporation, Monash University
    Inventors: Ismail Kola, Martin J. Tymms, Christine Debouck
  • Human lymphoid cells expressing human immunodeficiency virus envelope protein gp160
    Patent number: 5580720
    Abstract: The present invention provides mammalian cells modified to stably express at least the entire human immunodeficiency virus-1 envelope protein gp160. The invention provides a vaccine comprising the cells of the invention. The invention also provides methods for screening compounds for their ability to inhibit formation of syncytia between cells that express HIV-1 gp160 and cells that express CD4 comprising mixing cells of invention, cells that express CD4 on their surfaces, and a test compound for a length of time sufficient for syncytia to form; and then determining the amount of syncytia formation.
    Type: Grant
    Filed: June 2, 1995
    Date of Patent: December 3, 1996
    Assignee: SmithKline Beecham Corporation
    Inventors: Zdenka L. Jonak, Christine Debouck, Robert Clark, Stephen Trulli
  • Human lymphoid cells expressing human immunodeficiency virus envelope protein GP160
    Patent number: 5462872
    Abstract: The present invention provides mammalian cells modified to stably express at least the entire human immunodeficiency virus-1 envelope protein gp160. The invention provides a vaccine comprising the cells of the invention. The invention also provides methods for screening compounds for their ability to inhibit formation of syncytia between cells that express HIV-1 gp160 and cells that express CD4 comprising mixing cells of invention, cells that express CD4 on their surfaces, and a test compound for a length of time sufficient for syncytia to form; and then determining the amount of syncytia formation.
    Type: Grant
    Filed: October 8, 1993
    Date of Patent: October 31, 1995
    Assignee: SmithKline Beecham Corporation
    Inventors: Zdenka L. Jonak, Christine Debouck, Robert Clark, Stephen Trulli