Patents by Inventor Christine Devijver

Christine Devijver has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • PROCESS FOR THE PRODUCTION OF EXENATIDE AND OF AN EXENATIDE ANALOGUE
    Publication number: 20110046349
    Abstract: Exenatide, a polypeptide having the 39 amino acid sequence H-1His-Gly-Glu-Gly-5Thr-Phe-Thr-Ser-Asp-10Leu-Ser- Lys-Gln-Met-15Glu-Glu-Glu--Ala-Val-20Arg-Leu-Phe- Ile-Glu-25Trp-Leu-Lys-Asn-Gly-30Gly-Pro-Ser-Ser- Gly-35Ala--Pro-Pro-Pro-Ser-NH2, respectively its 44-mer analogue H-1His-Gly-Glu-Gly-5Thr-Phe-Thr-Ser-Asp-10Leu-Ser- Lys-Gln-Met-15Glu-Glu-Glu--Ala-Val-20Arg-Leu-Phe- Ile-Glu-25Trp-Leu-Lys-Asn-Gly-30Gly-Pro-Ser-Ser- Gly-35Ala--Pro-Pro-Ser-Lys-40Lys-Lys-Lys-Lys-Lys- NH2 is prepared via a convergent four-fragment synthesis strategy from the fragments comprising the amino acid positions 1-10, 11-21, 22-29 and 30-39, respectively 30-44.
    Type: Application
    Filed: July 14, 2010
    Publication date: February 24, 2011
    Inventors: Matthieu Giraud, Anne-Sophie Droz, Stéphane Varray, El Djouhar Rekai, Marie-Hèléne Brichard, Daniel Latassa, Christine Devijver, Pascal Gilles, Jeanne-Marie Cauvin, Fernando Albericio, Marta Paradis Bas
  • Processes for Preparing Eptifibatide
    Publication number: 20100105609
    Abstract: The present invention provides, inter alia, convergent processes for preparing eptifibatide that involve coupling a 2-6 eptifibatide fragment to an activated cysteinamide residue to form a 2-7 eptifibatide fragment, attaching a mercaptopropionic acid residue to the 2-7 eptifibatide fragment through disulfide bond formation, coupling the peptide intramolecularly, and removing the protecting group, to form eptifibatide. The invention further provides products produced by the described processes, novel compounds that can be used as synthetic intermediates for the preparation of eptifibatide, and novel compounds that are structurally similar to eptifibatide.
    Type: Application
    Filed: October 23, 2009
    Publication date: April 29, 2010
    Applicants: Millennium Pharmaceuticals, Inc., UBC,S.A.
    Inventors: Guojie Ho, Antionette D. Paone, Luciano Forni, Catherine De Tollenaere, Brice Bonnett, Christine Devijver
  • Processes for preparing eptifibatide
    Patent number: 7674768
    Abstract: The present invention provides, inter alia, convergent processes for preparing eptifibatide that involve coupling a 2-6 eptifibatide fragment to an activated cysteinamide residue to form a 2-7 eptifibatide fragment, attaching a mercaptopropionic acid residue to the 2-7 eptifibatide fragment through disulfide bond formation, coupling the peptide intramolecularly, and removing the protecting group, to form eptifibatide. The invention further provides products produced by the described processes, novel compounds that can be used as synthetic intermediates for the preparation of eptifibatide, and novel compounds that are structurally similar to eptifibatide.
    Type: Grant
    Filed: April 8, 2005
    Date of Patent: March 9, 2010
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Guojie Ho, Antoinette D. Paone, Luciano Forni, Catherine De Tollenaere, Brice Bonnet, Christine Devijver
  • Processes for preparing eptifibatide
    Publication number: 20060036071
    Abstract: The present invention provides, inter alia, convergent processes for preparing eptifibatide that involve coupling a 2-6 eptifibatide fragment to an activated cysteinamide residue to form a 2-7 eptifibatide fragment, attaching a mercaptopropionic acid residue to the 2-7 eptifibatide fragment through disulfide bond formation, coupling the peptide intramolecularly, and removing the protecting group, to form eptifibatide. The invention further provides products produced by the described processes, novel compounds that can be used as synthetic intermediates for the preparation of eptifibatide, and novel compounds that are structurally similar to eptifibatide.
    Type: Application
    Filed: April 8, 2005
    Publication date: February 16, 2006
    Inventors: Guojie Ho, Antoinette Paone, Luciano Forni, Catherine De Tollenaere, Brice Bonnet, Christine Devijver