Abstract: A control system for independent alternating-input (“IAI”) devices includes multiple IAI devices and an analog switch component. The control system may also include a bus-generating component. The analog switch component includes multiple switches configured to connect of disconnect input connection points of the analog switch component and voltage input points of the IAI devices. The analog switch component opens or closes switches, responsive to a digital control signal, to provide voltage signals to the voltage input points of the IAI devices. In some cases, the IAI devices activate or deactivate based on the provided voltage signals. In some cases, the bus-generating component provides a first voltage signal to a first voltage input point of an IAI device, and the analog switch component controls the switches to provide a second voltage signal to a second voltage input point of the IAI device.

Abstract: A control system for independent alternating-input (“IAI”) devices includes multiple IAI devices and an analog switch component. The control system may also include a bus-generating component. The analog switch component includes multiple switches configured to connect of disconnect input connection points of the analog switch component and voltage input points of the IAI devices. The analog switch component opens or closes switches, responsive to a digital control signal, to provide voltage signals to the voltage input points of the IAI devices. In some cases, the IAI devices activate or deactivate based on the provided voltage signals. In some cases, the bus-generating component provides a first voltage signal to a first voltage input point of an IAI device, and the analog switch component controls the switches to provide a second voltage signal to a second voltage input point of the IAI device.

Abstract: The present disclosure relates to non-emissive modular light-diffuser devices that selectively revealing reflective material and that can be utilized in applications ranging from wearable electronics to large format displays. For example, by applying power, the modular light-diffuser devices can switch from a light-scattering state and a non-light-scattering state to reveal reflective material beneath. In particular, a modular light-diffuser device can utilize dual inputs to provide an alternating low-voltage current to a PDLC film layer (e.g., by rotating the direction of electrical polarity), thus, significantly extending the life of the modular light-diffuser device. In addition, multiple modular light-diffuser devices can be grouped and added to objects (e.g., clothing, fashion accessories, or large format displays) to form patterns, designs, and animations based on the modular light-diffuser devices changing states.

Abstract: The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula I.

Abstract: This invention provides a combination of antagonists of the hedgehog signaling pathway with a BCR-ABL inhibitor. The combination of the present invention may be used for treating cancers known to be associated with protein tyrosine kinases such as, for example, Src, BCR-ABL and c-kit.

Abstract: This invention relates to the use of antagonists of the hedgehog signaling pathway to induce apoptosis of lymphoma and myeloma cells and to treat subjects suffering from various forms of lymphoma or myeloma.

Abstract: This invention provides a combination of ATP-competitive BCR-ABL inhibitor and a non-ATP competitive BCR-ABL inhibitor. The combination of the present invention may be used for treating cancers known to be associated with BCR-ABL.

Abstract: This invention provides a combination of antagonists of the hedgehog signaling pathway with a BCR-ABL inhibitor. The combination of the present invention may be used for treating cancers known to be associated with protein tyrosine kinases such as, for example, Src, BCR-ABL and c-kit.

Abstract: The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula I.