Patents by Inventor Christine Edwards

Christine Edwards has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF
    Publication number: 20190233441
    Abstract: Compounds of Formula 0, Formula I and Formula II and methods of use as Janus kinase inhibitors are described herein.
    Type: Application
    Filed: April 2, 2019
    Publication date: August 1, 2019
    Applicant: Genentech, Inc.
    Inventors: Nicholas C. Ray, Yun-Xing Cheng, Christine Edwards, Simon C. Goodacre, Wei Li, Snahel Patel, Matthew W. Cartwright, Mohammed Sajad, Po-wai Yuen, Mark E. Zak
  • TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF
    Publication number: 20180298033
    Abstract: Compounds of Formula 0, Formula I and Formula II and methods of use as Janus kinase inhibitors are described herein.
    Type: Application
    Filed: December 14, 2017
    Publication date: October 18, 2018
    Applicant: Genentech, Inc.
    Inventors: Nicholas C. Ray, Yun-Xing Cheng, Christine Edwards, Simon C. Goodacre, Wei Li, Snahel Patel, Matthew W. Cartwright, Mohammed Sajad, Po-wai Yuen, Mark E. Zak
  • TYROSINE AMIDE DERIVATIVES AS RHO- KINASE INHIBITORS
    Publication number: 20180215758
    Abstract: Bicyclic dihydropyrimidine-carboxamide compounds of formula I described herein inhibit Rho Kinase and may be used for the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF) and pulmonary arterial hypertension (PAH).
    Type: Application
    Filed: January 30, 2018
    Publication date: August 2, 2018
    Applicant: CHIESI FARMACEUTICI S.P.A.
    Inventors: Alessandro Accetta, Fabio Rancati, Anna Maria Capelli, David Edward Clark, Patrizia Tisselli, Christine Edwards, Gurdip Bhalay, Arnaud Jean Francois Auguste Cheguillaume
  • BICYCLIC DIHYDROPYRIMIDINE-CARBOXAMIDE DERIVATIVES AS RHO- KINASE INHIBITORS
    Publication number: 20180170939
    Abstract: Bicyclic dihydropyrimidine-carboxamide compounds of formula I described herein inhibit Rho Kinase and may be useful in the treatment of many disorders associated with ROCK enzymes mechanisms, such as pulmonary diseases including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), and pulmonary arterial hypertension (PAH).
    Type: Application
    Filed: December 21, 2017
    Publication date: June 21, 2018
    Applicant: CHIESI FARMACEUTISI S.p.A.
    Inventors: Alessandro Accetta, Fabio Rancati, Anna Maria Capelli, David Edward Clark, Patrizia Tisselli, Christine Edwards, Gurdip Bhalay
  • Triazolopyridine compounds, compositions and methods of use thereof
    Patent number: 9873709
    Abstract: Compounds of Formula 0, Formula I and Formula II and methods of use as Janus kinase inhibitors are described herein.
    Type: Grant
    Filed: April 27, 2017
    Date of Patent: January 23, 2018
    Assignee: Genentech, Inc.
    Inventors: Nicholas C. Ray, Yun-Xing Cheng, Christine Edwards, Simon C. Goodacre, Wei Li, Snahel Patel, Matthew W. Cartwright, Mohammed Sajad, Po-wai Yuen, Mark E. Zak
  • TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF
    Publication number: 20170226132
    Abstract: Compounds of Formula 0, Formula I and Formula II and methods of use as Janus kinase inhibitors are described herein.
    Type: Application
    Filed: April 27, 2017
    Publication date: August 10, 2017
    Applicant: Genentech, Inc.
    Inventors: Nicholas C. Ray, Yun-Xing Cheng, Christine Edwards, Simon C. Goodacre, Wei Li, Snahel Patel, Matthew W. Cartwright, Mohammed Sajad, Po-wai Yuen, Mark E. Zak
  • TRIAZOLOPYRIDINE COMPOUNDS, COMPOSITIONS AND METHODS OF USE THEREOF
    Publication number: 20160185780
    Abstract: Compounds of Formula 0, Formula I and Formula II and methods of use as Janus kinase inhibitors are described herein.
    Type: Application
    Filed: March 4, 2016
    Publication date: June 30, 2016
    Applicant: Genentech, Inc.
    Inventors: Nicholas C. RAY, Yun-Xing CHENG, Christine EDWARDS, Simon C. GOODACRE, Wei LI, Snahel PATEL, Matthew W. CARTWRIGHT, Mohammed SAJAD, Po-wai YUEN, Mark E. ZAK
  • Pyrimidine derivatives and their use in the treatment of respiratory diseases such a COPD
    Patent number: 9156844
    Abstract: Compounds of formula (I) are inhibitors of neutrophil elastase, wherein A is C—R1 or N; —X1—X2— is CR15?N— or —NR19—CO—; and R1-R6, R15, R15 and R19 are as defined in the claims.
    Type: Grant
    Filed: March 10, 2011
    Date of Patent: October 13, 2015
    Assignee: Chiesi Farmaceutici S.p.A.
    Inventors: Christine Edwards, Janusz Kulagowski, Harry Finch
  • Pyrimidine derivatives and their use in the treatment of respiratory diseases such as COPD
    Patent number: 9120802
    Abstract: Compounds of formula (I) are inhibitors of neutrophil elastase, wherein A is C—R1 or N; —X1—X2— is CR15?N— or —NR19—CO—; and R1-R6, R15 and R16 are as defined in the claims.
    Type: Grant
    Filed: March 10, 2011
    Date of Patent: September 1, 2015
    Assignee: Chiesi Farmaceutici S.p.A.
    Inventors: Christine Edwards, Janusz Kulagowski, Harry Finch
  • Compounds
    Patent number: 9023855
    Abstract: Compounds of formula (I): are useful as inhibitors of human neutrophil elastase.
    Type: Grant
    Filed: February 11, 2014
    Date of Patent: May 5, 2015
    Assignee: Chiesi Farmaceutici S.p.A.
    Inventors: Toby Jonathan Blench, Christine Edwards, Robert Andrew Heald, Janusz Jozef Kulagowski, Jonathan Mark Sutton, Carmelida Capaldi
  • Tetrahydropyrrolopyrimidinediones and their use in therapy
    Patent number: 8957082
    Abstract: The subject invention provides compounds of formula (I): Including monomers and multimers thereof that are inhibitors of human neutrophil elastase (HNE) activity and are useful in the treatment of diseases or conditions in which HNE plays a part.
    Type: Grant
    Filed: April 17, 2012
    Date of Patent: February 17, 2015
    Assignee: Chiesi Farmaceutici S.p.A
    Inventors: Nicholas Charles Ray, Harry Finch, Christine Edwards, Elizabeth O'Connor
  • NOVEL COMPOUNDS
    Publication number: 20140179714
    Abstract: Compounds of formula (I): are useful as inhibitors of human neutrophil elastase.
    Type: Application
    Filed: February 11, 2014
    Publication date: June 26, 2014
    Applicant: Chiesi Farmaceutici S.p.A.
    Inventors: Toby Jonathan Blench, Christine Edwards, Robert Andrew Heald, Janusz Jozef Kulagowski, Jonathan Mark Sutton, Carmelida Capaldi
  • Compounds
    Patent number: 8691826
    Abstract: Compounds of formula (I): are useful as inhibitors of human neutrophil elastase.
    Type: Grant
    Filed: September 13, 2012
    Date of Patent: April 8, 2014
    Assignee: Chiesi Farmaceutici S.p.A.
    Inventors: Toby Jonathan Blench, Christine Edwards, Robert Andrew Heald, Janusz Jozef Kulagowski, Jonathan Mark Sutton, Carmelida Capaldi
  • Indazole carboxamides and their use
    Patent number: 8501780
    Abstract: The invention is directed to novel indazole carboxamide derivatives. Specifically, the invention is directed to compounds according to Formula I: wherein R1 and Z are defined below, and to pharmaceutically-acceptable salts thereof. The compounds of the invention are inhibitors of IKK2 and can be useful in the treatment of disorders associated with inappropriate IKK2 (also known as IKK?) activity, such as rheumatoid arthritis, asthma, and COPD (chronic obstructive pulmonary disease). Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting IKK2 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
    Type: Grant
    Filed: June 24, 2005
    Date of Patent: August 6, 2013
    Assignee: GlaxoSmithKline LLC
    Inventors: Jeffrey K. Kerns, Christine Edwards
  • PYRIMIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF RESPIRATORY DISEASES SUCH AS COPD
    Publication number: 20130150380
    Abstract: Compounds of formula (I) are inhibitors of neutrophil elastase, wherein A is C—R1 or N; —X1-X2— is CR15?N— or —NR19—CO—; and R1-R6, R15, R15 and R19 are as defined in the claims.
    Type: Application
    Filed: March 10, 2011
    Publication date: June 13, 2013
    Applicant: CHIESI FARMACEUTICI S.p.A.
    Inventors: Christine Edwards, Janusz Kulagowski, Harry Finch
  • Pyrrolopyrimidinedione and its therapeutic use
    Patent number: 8455505
    Abstract: The compound of formula (I) is an inhibitor of human neutrophil elastase, useful for inhalation treatment of pulmonary inflammation.
    Type: Grant
    Filed: January 22, 2010
    Date of Patent: June 4, 2013
    Assignee: Chiesi Farmaceutici S.p.A.
    Inventors: Christine Edwards, Janus Kulagowski, Harry Finch
  • PYRIMIDINE DERIVATIVES AND THEIR USE IN THE TREATMENT OF RESPIRATORY DISEASES SUCH AS COPD
    Publication number: 20130123278
    Abstract: Compounds of formula (I) are inhibitors of neutrophil elastase, wherein A is C—R1 or N; -X1-X2- is CR15?N— or —NR19—CO—; and R1-R6, R15 and R16 are as defined in the claims.
    Type: Application
    Filed: March 10, 2011
    Publication date: May 16, 2013
    Applicant: CHIESI FARMACEUTICI S.p.A.
    Inventors: Christine Edwards, Janusz Kulagowski, Harry Finch
  • NOVEL COMPOUNDS
    Publication number: 20130065913
    Abstract: Compounds of formula (I): are useful as inhibitors of human neutrophil elastase.
    Type: Application
    Filed: September 13, 2012
    Publication date: March 14, 2013
    Applicant: Chiesi Farmaceutici S.p.A.
    Inventors: Toby Jonathan Blench, Christine Edwards, Robert Andrew Heald, Janusz Jozef Kulagowski, Jonathan Mark Sutton, Carmelida Capaldi
  • Tetrahydropyrrolopyrimidinediones And Their Use In Therapy
    Publication number: 20120202826
    Abstract: The subject invention provides compounds of formula (I): Including monomers and multimers thereof that are inhibitors of human neutrophil elastase (HNE) activity and are useful in the treatment of diseases or conditions in which HNE plays a part.
    Type: Application
    Filed: April 17, 2012
    Publication date: August 9, 2012
    Inventors: Nicholas Charles RAY, Harry Finch, Christine Edwards, Elizabeth O'Connor
  • Tetrahydropyrrolopyrimidinediones and their use in therapy
    Patent number: 8198288
    Abstract: The subject invention provides compounds of formula (1): including monomers and multimers thereof that are inhibitors of human neutrophil elastase (HNE) activity and are useful in the treatment of diseases or conditions in which HNE plays a part.
    Type: Grant
    Filed: November 4, 2008
    Date of Patent: June 12, 2012
    Assignee: Pulmagen Therapeutics (Inflammation) Limited
    Inventors: Nicholas Charles Ray, Harry Finch, Christine Edwards, Elizabeth O'Connor