Patents by Inventor Christine Gjerdrum Rines

Christine Gjerdrum Rines has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • MODIFIED INDUCED PLURIPOTENT STEM CELL (iPSC) DERIVED MICROGLIA FOR THE TREATMENT OF BRAIN CANCER
    Publication number: 20220348866
    Abstract: The present disclosure provides modified induced pluripotent stem cell (iPSC) derived microglia comprising a microglia targeting and activation protein, a microglia regulatory protein, an interfering RNA sequence, a microRNA effector, a non-coding RNA effector, at least one transgene encoding the aforementioned, or a combination thereof. Also provided are methods for treating cancer (e.g., brain cancers) and sensitizing cancer cells to phagocytosis and other cell death pathways with the modified induced pluripotent stem cell (iPSC) derived microglia.
    Type: Application
    Filed: April 14, 2022
    Publication date: November 3, 2022
    Inventors: Patrick M. McDonough, Jeffrey H. Price, Daniel R. Rines, Christine Gjerdrum Rines, Ranor C. B. Basa