Patents by Inventor Christine Gless

Christine Gless has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for the production of proteins and peptides
    Patent number: 8828670
    Abstract: The invention relates to a method for producing monomeric or dimeric proteins or peptides containing internal or external disulfide bonds, comprising the following steps: a) a cell-free lysate, obtainable from eukaryotic cells, is provided, which contains functional microsomal vesicles, b) a nucleic acid coding the protein or peptide and additionally containing a signal sequence is added to the lysate, c) the lysate with the nucleic acid is held for a given time at a temperature in the range from 20 to 35° C., proteins or peptides formed with the nucleic acid being translocated into the microsomal vesicles, d) the microsomal vesicles are then dissolved, and the proteins or peptides obtained thereby are optionally separated from the lysate.
    Type: Grant
    Filed: July 10, 2012
    Date of Patent: September 9, 2014
    Assignee: RiNA Netzwerk RNA Technologien GmbH
    Inventors: Helmut Merk, Wolfgang Stiege, Christine Gless, Michael Gerrits
  • METHOD FOR THE PRODUCTION OF PROTEINS AND PEPTIDES
    Publication number: 20130017576
    Abstract: The invention relates to a method for producing monomeric or dimeric proteins or peptides containing internal or external disulfide bonds, comprising the following steps: a) a cell-free lysate, obtainable from eukaryotic cells, is provided, which contains functional microsomal vesicles, b) a nucleic acid coding the protein or peptide and additionally containing a signal sequence is added to the lysate, c) the lysate with the nucleic acid is held for a given time at a temperature in the range from 20 to 35° C., proteins or peptides formed with the nucleic acid being translocated into the microsomal vesicles, d) the microsomal vesicles are then dissolved, and the proteins or peptides obtained thereby are optionally separated from the lysate.
    Type: Application
    Filed: July 10, 2012
    Publication date: January 17, 2013
    Applicant: RINA NETZWERK RNA TECHNLOGIEN GMBH
    Inventors: Helmut Merk, Wolfgang Stiege, Christine Gless, Michael GERRITS