Patents by Inventor Christine J. Morrison
Christine J. Morrison has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8119788Abstract: Compositions and methods for detecting and/or differentiating among Candida organisms, including C. albicans and C. dubliniensis, are disclosed. Exemplary methods involve screening a sample suspected of containing at least one or more Candida sp. for the presence or absence of a nucleic acid sequence specific for each such fungal pathogen. Some disclosed methods permit the rapid and simultaneous detection and identification of several fungal pathogens (e.g., up to 100 fungi) in a single sample.Type: GrantFiled: September 26, 2006Date of Patent: February 21, 2012Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services, Centers for Disease Control and PreventionInventors: Christine J. Morrison, Sanchita Das, Teresa Brown, Brian Holloway
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Patent number: 7871779Abstract: Novel techniques for the detection of Aspergillus in samples are disclosed. These techniques relate to PCR amplification and/or detection of Aspergillus ITS1 rDNA sequences, and the identification of particular species of Aspergillus by detecting differences in the ITS1-V1, ITS-V2, ITS-V3, ITS-V4, and ITS-V5 nucleic acid sequences of Aspergillus. The highly variable regions of the ITS1 rDNA sequences are particularly useful in distinguishing, for example, Aspergillus clavatus, Aspergillus granulosus, Aspergillus sydowii, Aspergillus flavipes, Aspergillus restrictus, Aspergillus versicolor, Aspergillus wentii, and Aspergillus chevalieri. In particular embodiments, the sequence differences are also able to distinguish among variants of particular species, such as Aspergillus granulosus CBS 119.Type: GrantFiled: May 5, 2008Date of Patent: January 18, 2011Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services, Centers for Disease Control and PreventionInventors: Christine J. Morrison, Hans Peter Hinrikson
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Publication number: 20080248970Abstract: Compositions and methods for detecting and/or differentiating among Candida organisms, including C. albicans and C. dubliniensis, are disclosed. Exemplary methods involve screening a sample suspected of containing at least one or more Candida sp. for the presence or absence of a nucleic acid sequence specific for each such fungal pathogen. Some disclosed methods permit the rapid and simultaneous detection and identification of several fungal pathogens (e.g., up to 100 fungi) in a single sample.Type: ApplicationFiled: September 26, 2006Publication date: October 9, 2008Inventors: Christine J. Morrison, Sanchita Das, Teresa Brown, Brian Holloway
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Patent number: 7427472Abstract: Methods of detecting a dimorphic fungus, including differentiating a dimorphic fungus from other fungi are disclosed. A sample suspected of containing a nucleic acid of a fungus, such as an internal transcribed spacer-2 (ITS2) nucleic acid sequence of a dimorphic fungal rDNA, is screened for the presence or absence of that nucleic acid. The presence of the nucleic acid indicates the sample was contacted by the fungus. Determining whether the nucleic acid sequence is present in the sample can be accomplished by detecting hybridization between a dimorphic probe, species-specific probe, and/or microbe-specific probe and a nucleic acid sequence corresponding to the ITS2 region of fungal rDNA. Kits and arrays for carrying out these methods also are disclosed.Type: GrantFiled: September 25, 2002Date of Patent: September 23, 2008Assignee: United States of America as represented by the Secretary of the Department of Health and Human Services, Centers for Disease Control and PreventionInventors: Mark D. Lindsley, Zhenyu Qin, Christine J. Morrison, Jong S. Choi
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Publication number: 20080227108Abstract: Novel techniques for the detection of Aspergillus in samples are disclosed. These techniques relate to PCR amplification and/or detection of Aspergillus ITS1 rDNA sequences, and the identification of particular species of Aspergillus by detecting differences in the ITS1-V1, ITS-V2, ITS-V3, ITS-V4, and ITS-V5 nucleic acid sequences of Aspergillus. The highly variable regions of the ITS1 rDNA sequences are particularly useful in distinguishing, for example, Aspergillus clavatus, Aspergillus granulosus, Aspergillus sydowii, Aspergillus flavipes, Aspergillus restrictus, Aspergillus versicolor, Aspergillus wentii, and Aspergillus chevalieri. In particular embodiments, the sequence differences are also able to distinguish among variants of particular species, such as Aspergillus granulosus CBS 119.Type: ApplicationFiled: May 5, 2008Publication date: September 18, 2008Inventors: Christine J. Morrison, Hans Peter Hinrikson
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Patent number: 7384741Abstract: Novel techniques for the detection of Aspergillus in samples are disclosed. These techniques relate to PCR amplification and/or detection of Aspergillus ITS1 rDNA sequences, and the identification of particular species of Aspergillus by detecting differences in the ITS1-V1, ITS-V2, ITS-V3, ITS-V4, and ITS-V5 nucleic acid sequences of Aspergillus. The highly variable regions of the ITS1 rDNA sequences are particularly useful in distinguishing, for example, Aspergillus clavatus, Aspergillus granulosus, Aspergillus sydowii, Aspergillus flavipes, Aspergillus restrictus, Aspergillus versicolor, Aspergillus wentii, and Aspergillus chevalieri. In particular embodiments, the sequence differences are also able to distinguish among variants of particular species, such as Aspergillus granulosus CBS 119.Type: GrantFiled: May 16, 2003Date of Patent: June 10, 2008Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Christine J. Morrison, Hans Peter Hinrikson
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Patent number: 7052836Abstract: Nucleic acids for detecting Aspergillus species and other filamentous fungi are provided. Unique internal transcribed space 2 coding regions permit the development of nucleic acid probes specific for five different species of Aspergillus, three species of Fusarium, four species of Mucor, two species of Penecillium, five species of Rhizopus, one species of Rhizomucor, as well as probes for Absidia corymbifer, Cunninghamella elagans, Pseudallescheria boydii, and Sporothrix schenkii. Methods are disclosed for the species-specific detection and diagnosis of infection by Aspergillus, Fusarium, Mucor, Penecillium, Rhizomucor, absidia, Cunninghaemella, Pseudallescheria or Sporthrix in a subject. Furthermore, genus-specific probes are also provided for Aspergillus, Fusarium and Mucor, in addition to an all-fungus nucleic acid probe.Type: GrantFiled: January 14, 2002Date of Patent: May 30, 2006Assignee: The Government of the United States of America as represented by the Secretary of the Department of Health and Human ServicesInventors: Christine J. Morrison, Errol Reiss, Jong Soo Choi, Liliana Aidorevich
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Publication number: 20030129600Abstract: Nucleic acids for detecting Aspergillus species and other filamentous fungi are provided. Unique internal transcribed spacer 2; coding regions permit the development of nucleic acid probes specific for five different species of Aspergillus, three species of Fusarium, four species of Mucor, two species of Penecillium, five species of Rhizopus, one species of Rhizomucor, as well as probes for Absidia corymbifera, Cunninghamella elagans, Pseudallescheria boydii, and Sporothrix schenkii. The invention thereby provides methods for the species-specific detection and diagnosis of infection by Aspergillus, Fusarium, Mucor, Penecillium, Rhizopus, Rhizomucor, Absidia, Cunninghamella, Pseudallescheria or Sporothrix in a subject. Furthermore, genus-specific probes are also provided for Aspergillus, Fusarium and Mucor, in addition to an all-fungus nucleic acid probe.Type: ApplicationFiled: January 14, 2002Publication date: July 10, 2003Applicant: Dept. of Health & Human Ser., c/o Ctr. for Disease Control & Prevention, Ofc. of Technology TransferInventors: Christine J. Morrison, Errol Reiss, Jong Soo Choi, Liliana Aidorevich
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Patent number: 6372430Abstract: Nucleic acids for detecting Aspergillus species and other filamentous fungi are provided. Unique internal transcribed space 2 coding regions permit the development of nucleic acid probes specific for five different species of Aspergillus, three species of Fusarium, four species of Mucor, two species of Penecillium, five species of Rhizopus, one species of Rhizomucor, as well as probes for Absidia corymbifer, Cunninghamella elagans, Pseudallescheria boydii, and Sporothrix schenkii. Methods are disclosed for the species-specific detection and diagnosis of infection by Aspergillus, Fusarium, Mucor, Penecillium, Rhizomucor, absidia, Cunninghaemella, Pseudallescheria or Sporthrix in a subject. Furthermore, genus-specific probes are also provided for Aspergillus, Fusarium and Mucor, in addition to an all-fungus nucleic acid probe.Type: GrantFiled: June 27, 2000Date of Patent: April 16, 2002Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Christine J. Morrison, Errol Reiss, Liliana Aidorevich, Jong Soo Choi
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Patent number: 6370189Abstract: The present invention provides apparatus and methods in which variable delay is provided for channel tracking. In particular, a demodulator having both a hard output (or symbol estimate) and a soft output (or indication of the quality of the symbol estimate) is coupled to a channel tracker. The channel tracker provides a channel estimate used by the demodulator, in part, to correct for fading. The channel tracker updates the channel estimate based on the symbol estimates from the demodulator and the received signal. However, when the soft output indicates a low confidence in the symbol estimate, the symbol estimate is not used to update the channel estimate. This is accomplished by providing a variable delay to the channel estimate calculation performed by the channel tracker depending on the number of consecutive suspect symbol estimates.Type: GrantFiled: May 27, 1998Date of Patent: April 9, 2002Assignee: Ericsson Inc.Inventors: Christine J. Morrison, Errol Reiss, Liliana Aidorevich, Jong Soo Choi
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Patent number: 6242178Abstract: The nucleic acid sequence encoding the internal transcribed spacer 2 region of Candida, the organism causing candidiasis, for various Candida species. Nucleic acid molecules useful as probes for detecting Candida species are described. The nucleic acid molecules are useful in methods for the detection and diagnosis of Candida infection in a sample or subject.Type: GrantFiled: July 30, 1997Date of Patent: June 5, 2001Assignee: Centers for Disease Control and PreventionInventors: Timothy J. Lott, Cheryl M. Elie, Christine J. Morrison, Errol Reiss
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Patent number: 6235890Abstract: The present invention provides a rapid method for identifying species of Candida. Identification is through the use of a non-conserved regions of the ITS2 region flanked by highly conserved functional domains. Detection of members of the Candida and Aspergillus genera is enhanced by the detection of genus-specific regions of the 5.8S rRNA gene. The present invention provides isolated nucleic acids that selectively hybridize to the fungal genus-specific 5.8S rRNA region, and to the species-specific ITS2 region. The invention provides for nucleic acid sequences for use as selective probes for fungal genus-specific probes and as Candida species-specific probes. The present invention provides methods for the use of the Candida species-specific probes that allow the detection and identification of the individual species in biological samples.Type: GrantFiled: July 12, 1999Date of Patent: May 22, 2001Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Christine J. Morrison, Errol Reiss, Brian Holloway, Jong Hee Shin
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Patent number: 5688644Abstract: Provided is an isolated double-stranded nucleic acid consisting essentially of the nucleotide sequences defined in the Sequence Listing by SEQ ID Nos:5-9. These are the ITS2 sequences for C. albicans, C. parapsilosis, C. tropicalis, C. glabrata and C. krusei. A method of diagnosing systemic candidiasis in a subject is also provided. The method comprises the steps of: (a) collecting blood from the subject into tubes containing detergent, polypropylene glycol, sodium poyantholesulfonate, and sodium ethylene diamine tetraacetic acid; (b) lysing Candida cells using ZYMOLYASE.RTM.-100T.TM.Type: GrantFiled: April 26, 1995Date of Patent: November 18, 1997Assignee: United States of AmericaInventors: Timothy J. Lott, Christine J. Morrison, Errol Reiss, Brent Lasker, Sandra Zakroff
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Patent number: 5645992Abstract: Provided is an isolated double-stranded nucleic acid consisting essentially of the nucleotide sequences defined in the Sequence Listing by SEQ ID Nos: 5-9. These are the ITS2 sequences for C. albicans, C. parapsilosis, C. tropicalis, C. glabrata and C. krusei. A method of diagnosing systemic candidiasis in a subject is also provided. The method comprises the steps of: (a) collecting blood from the subject into tubes containing detergent, polypropylene glycol, sodium poyantholesulfonate, and sodium ethylene diamine tetraacetic acid; (b) lysing Candida cells using ZYMOLYASE.RTM.-100T with agitation; (c) extracting and precipitating the DNA from the lysed cells; (d) amplifying the precipitated DNA using universal fungal primer pairs derived from the internal transcribed spacer regions of the Candida ribosomal DNA; and (e) detecting amplified DNA from Candida by hybridizing the amplified DNA with a probe that selectively hybridizes with Candida DNA, the presence of amplified DNA indicating systemic candidiasis.Type: GrantFiled: April 26, 1995Date of Patent: July 8, 1997Assignee: The United States of America As Represented By The Secretary of Health and Human ServicesInventors: Timothy J. Lott, Christine J. Morrison, Errol Reiss, Brent Lasker, Sandra Zakroff
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Patent number: 5635353Abstract: Provided is an isolated double-stranded nucleic acid consisting essentially of the nucleotide sequences defined in the Sequence Listing by SEQ ID Nos:5-9. These are the ITS2 sequences for C. albicans, C. parapsilosis, C. tropicalis, C. glabrata and C. krusei. A method of diagnosing systemic candidiasis in a subject is also provided. The method comprises the steps of: (a) collecting blood from the subject into tubes containing detergent, polypropylene glycol, sodium poyantholesulfonate, and sodium ethylene diamine tetraacetic acid; (b) lysing Candida cells using ZYMOLYASE.RTM.-100T with agitation; (c) extracting and precipitating the DNA from the lysed cells; (d) amplifying the precipitated DNA using universal fungal primer pairs derived from the internal transcribed spacer regions of the Candida ribosomal DNA; and (e) detecting amplified DNA from Candida by hybridizing the amplified DNA with a probe that selectively hybridizes with Candida DNA, the presence of amplified DNA indicating systemic candidiasis.Type: GrantFiled: April 26, 1995Date of Patent: June 3, 1997Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Timothy J. Lott, Christine J. Morrison, Errol Reiss, Brent Lasker, Sandra Zakroff
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Patent number: 5631132Abstract: Provided is an isolated double-stranded nucleic acid consisting essentially of the nucleotide sequences defined in the Sequence Listing by SEQ ID NOs: 5-9. These are the ITS2 sequences for C. albicans, C. parapsilosis, C. tropicalis, C. glabrata and C. krusei. A method of diagnosing systemic candidiasis in a subject is also provided. The method comprises the steps of: (a) collecting blood from the subject into tubes containing detergent, polypropylene glycol, sodium poyantholesulfonate, and sodium ethylene diamine tetraacetic acid; (b) lysing Candida cells using ZYMOLYASE.RTM.-100T with agitation; (c) extracting and precipitating the DNA from the lysed cells; (d) amplifying the precipitated DNA using universal fungal primer pairs derived from the internal transcribed spacer regions of the Candida ribosomal DNA; and (e) detecting amplified DNA from Candida by hybridizing the amplified DNA with a probe that selectively hybridizes with Candida DNA, the presence of amplified DNA indicating systemic candidiasis.Type: GrantFiled: April 26, 1995Date of Patent: May 20, 1997Assignee: The United States of America as represented by the Department of Health and Human ServicesInventors: Timothy J. Lott, Christine J. Morrison, Errol Reiss, Brent Lasker, Sandra Zakroff
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Patent number: 5426027Abstract: Provided is an isolated double-stranded nucleic acid consisting essentially of the nucleotide sequence defined in the Sequence Listing by SEQ ID NO:5. This is the C. albicans ITS2 sequence and includes a nucleic acid comprising a nucleotide sequence that is specific for Candida albicans. Further examples of an isolated double stranded nucleic acid of the present invention consist essentially of the nucleotide sequences defined in the Sequence Listing by SEQ ID NOs:6-9. These are the ITS2 sequences for C. parapsilosis, C. tropicalis, C. glabrata and C. krusei. A method of diagnosing systemic candidiasis in a subject is also provided. The method comprises the steps of: (a) collecting blood from the subject into tubes containing detergent, polypropylene glycol, sodium polyanetholesulfonate, and sodium ethylene diamine.RTM. tetraacetic acid; (b) lysing Candida cells using ZYMOLYASE.RTM.Type: GrantFiled: May 20, 1993Date of Patent: June 20, 1995Assignee: The Government of the United States of America as represented by the SecretaryInventors: Timothy J. Lott, Christine J. Morrison, Errol Reiss, Brent Lasker, Sandra Zakroff