Abstract: The present invention relates to compositions, methods and kits for the treatment of respiratory disease. In particular, the compositions, methods and kits are particularly useful, but not limited to, the treatment or prevention of exacerbations of asthma and chronic obstructive pulmonary disease. The present invention provides a method of treating or preventing a respiratory disease in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of an inhibitor of casein kinase 1, thereby treating or preventing a respiratory disease in a subject. The present invention also provides a method of treating or preventing a respiratory disease in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of an inhibitor of ALK5, thereby treating or preventing a respiratory disease in a subject, wherein the inhibitor is administered directly to the airway and/or lungs.

Abstract: The present invention relates to compositions, methods and kits for the treatment of respiratory disease. In particular, the compositions, methods and kits are particularly useful, but not limited to, the treatment or prevention of exacerbations of asthma and chronic obstructive pulmonary disease. The present invention provides a method of treating or preventing a respiratory disease in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of an inhibitor of casein kinase 1, thereby treating or preventing a respiratory disease in a subject. The present invention also provides a method of treating or preventing a respiratory disease in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of an inhibitor of ALK5, thereby treating or preventing a respiratory disease in a subject, wherein the inhibitor is administered directly to the airway and/or lungs.

Abstract: The present invention relates to compositions, methods and kits for the treatment of respiratory disease. In particular, the compositions, methods and kits are particularly useful, but not limited to, the treatment or prevention of exacerbations of asthma and chronic obstructive pulmonary disease. The present invention provides a method of treating or preventing a respiratory disease in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of an inhibitor of casein kinase 1, thereby treating or preventing a respiratory disease in a subject. The present invention also provides a method of treating or preventing a respiratory disease in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of an inhibitor of ALK5, thereby treating or preventing a respiratory disease in a subject, wherein the inhibitor is administered directly to the airway and/or lungs.

Abstract: Methods for treating inflammation, including allergic inflammation, lymphocyte-driven inflammation, and inflammatory conditions such as allergic asthma and allergic lung inflammation, using inhibitors of the polycomb repressive complex 2 (PRC2) methyltransferase enhancer of zeste homolog 2 (Ezh2) are provided.

Abstract: The present invention relates to compositions, methods and kits for the treatment of respiratory disease. In particular, the compositions, methods and kits are particularly useful, but not limited to, the treatment or prevention of exacerbations of asthma and chronic obstructive pulmonary disease. The present invention provides a method of treating or preventing a respiratory disease in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of an inhibitor of casein kinase 1, thereby treating or preventing a respiratory disease in a subject. The present invention also provides a method of treating or preventing a respiratory disease in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of an inhibitor of ALK5, thereby treating or preventing a respiratory disease in a subject, wherein the inhibitor is administered directly to the airway and/or lungs.

Abstract: The present invention relates to compositions, methods and kits for the treatment of respiratory disease. In particular, the compositions, methods and kits are particularly useful, but not limited to, the treatment or prevention of exacerbations of asthma and chronic obstructive pulmonary disease. The present invention provides a method of treating or preventing a respiratory disease in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of an inhibitor of casein kinase 1, thereby treating or preventing a respiratory disease in a subject. The present invention also provides a method of treating or preventing a respiratory disease in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of an inhibitor of ALK5, thereby treating or preventing a respiratory disease in a subject, wherein the inhibitor is administered directly to the airway and/or lungs.

Abstract: The present invention relates to compositions, methods and kits for the treatment of respiratory disease. In particular, the compositions, methods and kits are particularly useful, but not limited to, the treatment or prevention of exacerbations of asthma and chronic obstructive pulmonary disease. The present invention provides a method of treating or preventing a respiratory disease in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of an inhibitor of casein kinase 1, thereby treating or preventing a respiratory disease in a subject. The present invention also provides a method of treating or preventing a respiratory disease in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of an inhibitor of ALK5, thereby treating or preventing a respiratory disease in a subject, wherein the inhibitor is administered directly to the airway and/or lungs.

Abstract: Apparatuses useful for printing and methods of stripping media from surfaces in apparatuses useful for printing are provided. An exemplary embodiment of an apparatus useful for printing comprises a first roll; a belt including an inner surface and an outer surface, the first roll and the outer surface of the belt forming a nip; and a stripping member located internal to the belt. The stripping member includes at least a first stripping surface and a second stripping surface having a smaller curvature than the first stripping surface. The stripping member is rotatable to selectively position one of the first stripping surface and the second stripping surface in contact with the inner surface of the belt. The one of the first stripping surface and the second stripping surface facilitates stripping of a medium fed to the nip from the outer surface of the belt.

Abstract: According to aspects of the embodiments, there is provided a method of optimizing an electro-photographic reproduction machine having a fusing subsystem and an air knife. The methods acquire at least one electro-photographic reproduction machine objective and media characteristic; and the acquired objective and characteristic are used to determine values for the pressurized air emitted from the air knife, the position of the air knife, and the rotation of the air knife relative to a fuse roll in the fusing subsystem. The methods further disclose acquiring the leading edge of the media being stripped and then using the beam strength of the media to assist in stripping the body of the sheet. The air knife can be controlled by a controller or a processor based on determined optimization parameter values that relate to objectives and media characteristics.

Abstract: Apparatuses useful for printing and methods of stripping media from surfaces in apparatuses useful for printing are provided. An exemplary embodiment of an apparatus useful for printing comprises a first roll; a belt including an inner surface and an outer surface, the first roll and the outer surface of the belt forming a nip; and a stripping member located internal to the belt. The stripping member includes at least a first stripping surface and a second stripping surface having a smaller curvature than the first stripping surface. The stripping member is rotatable to selectively position one of the first stripping surface and the second stripping surface in contact with the inner surface of the belt. The one of the first stripping surface and the second stripping surface facilitates stripping of a medium fed to the nip from the outer surface of the belt.

Abstract: According to aspects of the embodiments, there is provided a method of optimizing an electro-photographic reproduction machine having a fusing subsystem and an air knife. The methods acquire at least one electro-photographic reproduction machine objective and media characteristic; and the acquired objective and characteristic are used to determine values for the pressurized air emitted from the air knife, the position of the air knife, and the rotation of the air knife relative to a fuse roll in the fusing subsystem. The methods further disclose acquiring the leading edge of the media being stripped and then using the beam strength of the media to assist in stripping the body of the sheet. The air knife can be controlled by a controller or a processor based on determined optimization parameter values that relate to objectives and media characteristics.

Abstract: Super wire history image defects in an image development system including one or more electrode wires disposed in a gap between a toner donor roll and an imaging member are reduced by providing an initial toner composition in the image development system, the initial toner composition containing at least 30 number % fine particles having a particle size no greater than 5 ?m; and providing replenisher toner into the development system to replenish the toner used to produce images by the image development system; the replenisher toner containing 20 number % or less fine particles having a particle size no greater than 5 ?m.

Abstract: Super wire history image defects in an image development system including one or more electrode wires disposed in a gap between a toner donor roll and an imaging member are reduced by providing an initial toner composition in the image development system, the initial toner composition containing at least 30 number % fine particles having a particle size no greater than 5 ?m; and providing replenisher toner into the development system to replenish the toner used to produce images by the image development system; the replenisher toner containing 20 number % or less fine particles having a particle size no greater than 5 ?m.