Patents by Inventor Christine Kuslich
Christine Kuslich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20170108503Abstract: Exosomes can be used for detecting biomarkers for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, for example, the stage or progression of a disease. Cell-of-origin exosomes can be used in profiling of physiological states or determining phenotypes. Biomarkers or markers from cell-of-origin specific exosomes can be used to determine treatment regimens for diseases, conditions, disease stages, and stages of a condition, and can also be used to determine treatment efficacy. Markers from cell-of-origin specific exosomes can also be used to identify conditions of diseases of unknown origin.Type: ApplicationFiled: December 29, 2016Publication date: April 20, 2017Inventors: Michael KLASS, Christine KUSLICH, George POSTE
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Publication number: 20150024961Abstract: Biomarkers such as exosomes and/or RNA, e.g., microRNA, can be used for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, for example, the stage or progression of a disease. Such biomarkers can be used in profiling of physiological states or determining phenotypes. Biomarkers can be used to determine treatment regimens for diseases, conditions, disease stages, and stages of a condition, and can also be used to determine treatment efficacy. Biomarkers can also be used to identify conditions of diseases of unknown origin.Type: ApplicationFiled: July 28, 2014Publication date: January 22, 2015Inventors: Michael KLASS, Christine KUSLICH, George POSTE
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Publication number: 20140162888Abstract: Biomarkers can be assessed for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, or the stage or progression of a disease. Circulating biomarkers from a bodily fluid can be used in profiling of physiological states or determining phenotypes. These include nucleic acids, protein, and circulating structures such as vesicles. Biomarkers can be used for theranostic purposes to select candidate treatment regimens for diseases, conditions, disease stages, and stages of a condition, and can also be used to determine treatment efficacy. The biomarkers can be circulating biomarkers, including vesicles and microRNA.Type: ApplicationFiled: April 6, 2011Publication date: June 12, 2014Inventors: Christine Kuslich, George Poste, Michael Klass, David Spetzler, Traci Pawlowski
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Publication number: 20140148348Abstract: Provided herein are methods and systems for characterizing a phenotype by detecting microRNAs, vesicles, or biomarkers that are indicative of disease or disease progress. The disease can be a gastrointestinal disorder, such as colorectal cancer. The microRNAs, vesicles, or biomarkers can be detected in a bodily fluid.Type: ApplicationFiled: January 13, 2011Publication date: May 29, 2014Inventors: Christine Kuslich, Traci Pawlowski, David Spetzler
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Publication number: 20140148350Abstract: Biomarkers can be assessed for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, or the stage or progression of a disease. Circulating biomarkers from a bodily fluid can be used in profiling of physiological states or determining phenotypes. These include nucleic acids, protein, and circulating structures such as vesicles. Biomarkers can be used for theranostic purposes to select candidate treatment regimens for diseases, conditions, disease stages, and stages of a condition, and can also be used to determine treatment efficacy. The biomarkers can be circulating biomarkers, including vesicles and microRNA.Type: ApplicationFiled: August 18, 2011Publication date: May 29, 2014Inventors: David Spetzler, Daniel Holterman, Traci Pawlowski, Christine Kuslich
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Publication number: 20130287772Abstract: Biomarkers can be assessed for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, or the stage or progression of a disease. Circulating biomarkers from a bodily fluid can be used in profiling of physiological states or determining phenotypes. These include nucleic acids, protein, and circulating structures such as vesicles. Biomarkers can be used for theranostic purposes to select candidate treatment regimens for diseases, conditions, disease stages, and stages of a condition, and can also be used to determine treatment efficacy. The biomarkers can be circulating biomarkers, including vesicles and microRNA.Type: ApplicationFiled: March 1, 2011Publication date: October 31, 2013Applicant: Caris Life Sciences Luxembourg HoldingsInventors: David D. Halbert, Christine Kuslich, George Poste, Micheal Klass, Daniel Spetzler, Andrea Tasinato, Daniel Holterman
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Publication number: 20130045882Abstract: Methods and compositions for the characterizing of cancers by assessing RNA levels, such as determining an RNA pattern, are provided herein. The diagnosis, prognosis, monitoring and treatment or a cancer can be determined by detecting one or more RNAs, such as microRNAs.Type: ApplicationFiled: July 6, 2012Publication date: February 21, 2013Inventors: Michael KLASS, Christine KUSLICH, George POSTE
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Publication number: 20130005599Abstract: Exosomes can be used for detecting biomarkers for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, for example, the stage or progression of a disease. Cell-of-origin exosomes can be used in profiling of physiological states or determining phenotypes. Biomarkers or markers from cell-of-origin specific exosomes can be used to determine treatment regimens for diseases, conditions, disease stages, and stages of a condition, and can also be used to determine treatment efficacy. Markers from cell-of-origin specific exosomes can also be used to identify conditions of diseases of unknown origin.Type: ApplicationFiled: July 6, 2012Publication date: January 3, 2013Applicants: Caris Life Sciences Luxembourg HoldingsInventors: Michael KLASS, Christine KUSLICH, George POSTE
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Patent number: 8278059Abstract: Exosomes can be used for detecting biomarkers for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, for example, the stage or progression of a disease. Cell-of-origin exosomes can be used in profiling of physiological states or determining phenotypes. Biomarkers or markers from cell-of-origin specific exosomes can be used to determine treatment regimens for diseases, conditions, disease stages, and stages of a condition, and can also be used to determine treatment efficacy. Markers from cell-of-origin specific exosomes can also be used to identify conditions of diseases of unknown origin.Type: GrantFiled: January 19, 2011Date of Patent: October 2, 2012Assignee: Caris Life Sciences Luxembourg Holdings, S.A.R.L.Inventors: Michael Klass, Christine Kuslich, George Poste
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Patent number: 8211653Abstract: Exosomes can be used for detecting biomarkers for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, for example, the stage or progression of a disease. Cell-of-origin exosomes can be used in profiling of physiological states or determining phenotypes. Biomarkers or markers from cell-of-origin specific exosomes can be used to determine treatment regimens for diseases, conditions, disease stages, and stages of a condition, and can also be used to determine treatment efficacy. Markers from cell-of-origin specific exosomes can also be used to identify conditions of diseases of unknown origin.Type: GrantFiled: January 19, 2011Date of Patent: July 3, 2012Assignee: Caris Life Sciences Luxembourg Holdings, S.A.R.L.Inventors: Michael Klass, Christine Kuslich, George Poste
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Patent number: 8192954Abstract: Methods and compositions for the characterizing of cancers by assessing RNA levels, such as determining an RNA pattern, are provided herein. The diagnosis, prognosis, monitoring and treatment or a cancer can be determined by detecting one or more RNAs, such as microRNAs.Type: GrantFiled: December 8, 2010Date of Patent: June 5, 2012Assignee: Caris Life Sciences Luxembourg Holdings, S.A.R.L.Inventors: Michael Klass, Christine Kuslich, George Poste
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Publication number: 20110237450Abstract: Exosomes can be used for detecting biomarkers for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, for example, the stage or progression of a disease. Cell-of-origin exosomes can be used in profiling of physiological states or determining phenotypes. Biomarkers or markers from cell-of-origin specific exosomes can be used to determine treatment regimens for diseases, conditions, disease stages, and stages of a condition, and can also be used to determine treatment efficacy. Markers from cell-of-origin specific exosomes can also be used to identify conditions of diseases of unknown origin.Type: ApplicationFiled: January 19, 2011Publication date: September 29, 2011Applicant: Caris Life Sciences Luxembourg HoldingsInventors: Michael R. Klass, Christine KUSLICH, George Poste
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Publication number: 20110151460Abstract: Exosomes can be used for detecting biomarkers for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, for example, the stage or progression of a disease. Cell-of-origin exosomes can be used in profiling of physiological states or determining phenotypes. Biomarkers or markers from cell-of-origin specific exosomes can be used to determine treatment regimens for diseases, conditions, disease stages, and stages of a condition, and can also be used to determine treatment efficacy. Markers from cell-of-origin specific exosomes can also be used to identify conditions of diseases of unknown origin.Type: ApplicationFiled: January 19, 2011Publication date: June 23, 2011Inventors: Michael Klass, Christine Kuslich, George Poste
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Patent number: 7897356Abstract: Exosomes can be used for detecting biomarkers for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, for example, the stage or progression of a disease. Cell-of-origin exosomes can be used in profiling of physiological states or determining phenotypes. Biomarkers or markers from cell-of-origin specific exosomes can be used to determine treatment regimens for diseases, conditions, disease stages, and stages of a condition, and can also be used to determine treatment efficacy. Markers from cell-of-origin specific exosomes can also be used to identify conditions of diseases of unknown origin.Type: GrantFiled: November 12, 2009Date of Patent: March 1, 2011Assignee: Caris Life SciencesInventors: Michael Klass, Christine Kuslich, George Poste
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Patent number: 7888035Abstract: Methods and compositions for the characterizing of cancers by assessing RNA levels, such as determining an RNA pattern, are provided herein. The diagnosis, prognosis, monitoring and treatment or a cancer can be determined by detecting one or more RNAs, such as microRNAs.Type: GrantFiled: October 30, 2009Date of Patent: February 15, 2011Assignee: Caris MPI, Inc.Inventors: Michael Klass, Christine Kuslich, George Poste
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Publication number: 20100203529Abstract: Exosomes can be used for detecting biomarkers for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, for example, the stage or progression of a disease. Cell-of-origin exosomes can be used in profiling of physiological states or determining phenotypes. Biomarkers or markers from cell-of-origin specific exosomes can be used to determine treatment regimens for diseases, conditions, disease stages, and stages of a condition, and can also be used to determine treatment efficacy. Markers from cell-of-origin specific exosomes can also be used to identify conditions of diseases of unknown origin.Type: ApplicationFiled: February 5, 2010Publication date: August 12, 2010Applicant: Caris MPI, Inc.Inventors: Christine Kuslich, George Poste, Michael Klass
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Publication number: 20100184046Abstract: Exosomes can be used for detecting biomarkers for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, for example, the stage or progression of a disease. Cell-of-origin exosomes can be used in profiling of physiological states or determining phenotypes. Biomarkers or markers from cell-of-origin specific exosomes can be used to determine treatment regimens for diseases, conditions, disease stages, and stages of a condition, and can also be used to determine treatment efficacy. Markers from cell-of-origin specific exosomes can also be used to identify conditions of diseases of unknown origin.Type: ApplicationFiled: November 12, 2009Publication date: July 22, 2010Applicant: Caris MPI, Inc.Inventors: Michael Klass, Christine Kuslich, George Poste
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Publication number: 20100113290Abstract: Methods and compositions for the characterizing of cancers by assessing RNA levels, such as determining an RNA pattern, are provided herein. The diagnosis, prognosis, monitoring and treatment or a cancer can be determined by detecting one or more RNAs, such as microRNAs.Type: ApplicationFiled: October 30, 2009Publication date: May 6, 2010Applicant: Caris MPI, Inc.Inventors: Michael KLASS, Christine Kuslich, George Poste