Patents by Inventor Christine Kuslich

Christine Kuslich has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20170108503
    Abstract: Exosomes can be used for detecting biomarkers for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, for example, the stage or progression of a disease. Cell-of-origin exosomes can be used in profiling of physiological states or determining phenotypes. Biomarkers or markers from cell-of-origin specific exosomes can be used to determine treatment regimens for diseases, conditions, disease stages, and stages of a condition, and can also be used to determine treatment efficacy. Markers from cell-of-origin specific exosomes can also be used to identify conditions of diseases of unknown origin.
    Type: Application
    Filed: December 29, 2016
    Publication date: April 20, 2017
    Inventors: Michael KLASS, Christine KUSLICH, George POSTE
  • Publication number: 20150024961
    Abstract: Biomarkers such as exosomes and/or RNA, e.g., microRNA, can be used for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, for example, the stage or progression of a disease. Such biomarkers can be used in profiling of physiological states or determining phenotypes. Biomarkers can be used to determine treatment regimens for diseases, conditions, disease stages, and stages of a condition, and can also be used to determine treatment efficacy. Biomarkers can also be used to identify conditions of diseases of unknown origin.
    Type: Application
    Filed: July 28, 2014
    Publication date: January 22, 2015
    Inventors: Michael KLASS, Christine KUSLICH, George POSTE
  • Publication number: 20140162888
    Abstract: Biomarkers can be assessed for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, or the stage or progression of a disease. Circulating biomarkers from a bodily fluid can be used in profiling of physiological states or determining phenotypes. These include nucleic acids, protein, and circulating structures such as vesicles. Biomarkers can be used for theranostic purposes to select candidate treatment regimens for diseases, conditions, disease stages, and stages of a condition, and can also be used to determine treatment efficacy. The biomarkers can be circulating biomarkers, including vesicles and microRNA.
    Type: Application
    Filed: April 6, 2011
    Publication date: June 12, 2014
    Inventors: Christine Kuslich, George Poste, Michael Klass, David Spetzler, Traci Pawlowski
  • Publication number: 20140148348
    Abstract: Provided herein are methods and systems for characterizing a phenotype by detecting microRNAs, vesicles, or biomarkers that are indicative of disease or disease progress. The disease can be a gastrointestinal disorder, such as colorectal cancer. The microRNAs, vesicles, or biomarkers can be detected in a bodily fluid.
    Type: Application
    Filed: January 13, 2011
    Publication date: May 29, 2014
    Inventors: Christine Kuslich, Traci Pawlowski, David Spetzler
  • Publication number: 20140148350
    Abstract: Biomarkers can be assessed for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, or the stage or progression of a disease. Circulating biomarkers from a bodily fluid can be used in profiling of physiological states or determining phenotypes. These include nucleic acids, protein, and circulating structures such as vesicles. Biomarkers can be used for theranostic purposes to select candidate treatment regimens for diseases, conditions, disease stages, and stages of a condition, and can also be used to determine treatment efficacy. The biomarkers can be circulating biomarkers, including vesicles and microRNA.
    Type: Application
    Filed: August 18, 2011
    Publication date: May 29, 2014
    Inventors: David Spetzler, Daniel Holterman, Traci Pawlowski, Christine Kuslich
  • Publication number: 20130287772
    Abstract: Biomarkers can be assessed for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, or the stage or progression of a disease. Circulating biomarkers from a bodily fluid can be used in profiling of physiological states or determining phenotypes. These include nucleic acids, protein, and circulating structures such as vesicles. Biomarkers can be used for theranostic purposes to select candidate treatment regimens for diseases, conditions, disease stages, and stages of a condition, and can also be used to determine treatment efficacy. The biomarkers can be circulating biomarkers, including vesicles and microRNA.
    Type: Application
    Filed: March 1, 2011
    Publication date: October 31, 2013
    Applicant: Caris Life Sciences Luxembourg Holdings
    Inventors: David D. Halbert, Christine Kuslich, George Poste, Micheal Klass, Daniel Spetzler, Andrea Tasinato, Daniel Holterman
  • Publication number: 20130045882
    Abstract: Methods and compositions for the characterizing of cancers by assessing RNA levels, such as determining an RNA pattern, are provided herein. The diagnosis, prognosis, monitoring and treatment or a cancer can be determined by detecting one or more RNAs, such as microRNAs.
    Type: Application
    Filed: July 6, 2012
    Publication date: February 21, 2013
    Inventors: Michael KLASS, Christine KUSLICH, George POSTE
  • Publication number: 20130005599
    Abstract: Exosomes can be used for detecting biomarkers for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, for example, the stage or progression of a disease. Cell-of-origin exosomes can be used in profiling of physiological states or determining phenotypes. Biomarkers or markers from cell-of-origin specific exosomes can be used to determine treatment regimens for diseases, conditions, disease stages, and stages of a condition, and can also be used to determine treatment efficacy. Markers from cell-of-origin specific exosomes can also be used to identify conditions of diseases of unknown origin.
    Type: Application
    Filed: July 6, 2012
    Publication date: January 3, 2013
    Applicants: Caris Life Sciences Luxembourg Holdings
    Inventors: Michael KLASS, Christine KUSLICH, George POSTE
  • Patent number: 8278059
    Abstract: Exosomes can be used for detecting biomarkers for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, for example, the stage or progression of a disease. Cell-of-origin exosomes can be used in profiling of physiological states or determining phenotypes. Biomarkers or markers from cell-of-origin specific exosomes can be used to determine treatment regimens for diseases, conditions, disease stages, and stages of a condition, and can also be used to determine treatment efficacy. Markers from cell-of-origin specific exosomes can also be used to identify conditions of diseases of unknown origin.
    Type: Grant
    Filed: January 19, 2011
    Date of Patent: October 2, 2012
    Assignee: Caris Life Sciences Luxembourg Holdings, S.A.R.L.
    Inventors: Michael Klass, Christine Kuslich, George Poste
  • Patent number: 8211653
    Abstract: Exosomes can be used for detecting biomarkers for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, for example, the stage or progression of a disease. Cell-of-origin exosomes can be used in profiling of physiological states or determining phenotypes. Biomarkers or markers from cell-of-origin specific exosomes can be used to determine treatment regimens for diseases, conditions, disease stages, and stages of a condition, and can also be used to determine treatment efficacy. Markers from cell-of-origin specific exosomes can also be used to identify conditions of diseases of unknown origin.
    Type: Grant
    Filed: January 19, 2011
    Date of Patent: July 3, 2012
    Assignee: Caris Life Sciences Luxembourg Holdings, S.A.R.L.
    Inventors: Michael Klass, Christine Kuslich, George Poste
  • Patent number: 8192954
    Abstract: Methods and compositions for the characterizing of cancers by assessing RNA levels, such as determining an RNA pattern, are provided herein. The diagnosis, prognosis, monitoring and treatment or a cancer can be determined by detecting one or more RNAs, such as microRNAs.
    Type: Grant
    Filed: December 8, 2010
    Date of Patent: June 5, 2012
    Assignee: Caris Life Sciences Luxembourg Holdings, S.A.R.L.
    Inventors: Michael Klass, Christine Kuslich, George Poste
  • Publication number: 20110237450
    Abstract: Exosomes can be used for detecting biomarkers for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, for example, the stage or progression of a disease. Cell-of-origin exosomes can be used in profiling of physiological states or determining phenotypes. Biomarkers or markers from cell-of-origin specific exosomes can be used to determine treatment regimens for diseases, conditions, disease stages, and stages of a condition, and can also be used to determine treatment efficacy. Markers from cell-of-origin specific exosomes can also be used to identify conditions of diseases of unknown origin.
    Type: Application
    Filed: January 19, 2011
    Publication date: September 29, 2011
    Applicant: Caris Life Sciences Luxembourg Holdings
    Inventors: Michael R. Klass, Christine KUSLICH, George Poste
  • Publication number: 20110151460
    Abstract: Exosomes can be used for detecting biomarkers for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, for example, the stage or progression of a disease. Cell-of-origin exosomes can be used in profiling of physiological states or determining phenotypes. Biomarkers or markers from cell-of-origin specific exosomes can be used to determine treatment regimens for diseases, conditions, disease stages, and stages of a condition, and can also be used to determine treatment efficacy. Markers from cell-of-origin specific exosomes can also be used to identify conditions of diseases of unknown origin.
    Type: Application
    Filed: January 19, 2011
    Publication date: June 23, 2011
    Inventors: Michael Klass, Christine Kuslich, George Poste
  • Patent number: 7897356
    Abstract: Exosomes can be used for detecting biomarkers for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, for example, the stage or progression of a disease. Cell-of-origin exosomes can be used in profiling of physiological states or determining phenotypes. Biomarkers or markers from cell-of-origin specific exosomes can be used to determine treatment regimens for diseases, conditions, disease stages, and stages of a condition, and can also be used to determine treatment efficacy. Markers from cell-of-origin specific exosomes can also be used to identify conditions of diseases of unknown origin.
    Type: Grant
    Filed: November 12, 2009
    Date of Patent: March 1, 2011
    Assignee: Caris Life Sciences
    Inventors: Michael Klass, Christine Kuslich, George Poste
  • Patent number: 7888035
    Abstract: Methods and compositions for the characterizing of cancers by assessing RNA levels, such as determining an RNA pattern, are provided herein. The diagnosis, prognosis, monitoring and treatment or a cancer can be determined by detecting one or more RNAs, such as microRNAs.
    Type: Grant
    Filed: October 30, 2009
    Date of Patent: February 15, 2011
    Assignee: Caris MPI, Inc.
    Inventors: Michael Klass, Christine Kuslich, George Poste
  • Publication number: 20100203529
    Abstract: Exosomes can be used for detecting biomarkers for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, for example, the stage or progression of a disease. Cell-of-origin exosomes can be used in profiling of physiological states or determining phenotypes. Biomarkers or markers from cell-of-origin specific exosomes can be used to determine treatment regimens for diseases, conditions, disease stages, and stages of a condition, and can also be used to determine treatment efficacy. Markers from cell-of-origin specific exosomes can also be used to identify conditions of diseases of unknown origin.
    Type: Application
    Filed: February 5, 2010
    Publication date: August 12, 2010
    Applicant: Caris MPI, Inc.
    Inventors: Christine Kuslich, George Poste, Michael Klass
  • Publication number: 20100184046
    Abstract: Exosomes can be used for detecting biomarkers for diagnostic, therapy-related or prognostic methods to identify phenotypes, such as a condition or disease, for example, the stage or progression of a disease. Cell-of-origin exosomes can be used in profiling of physiological states or determining phenotypes. Biomarkers or markers from cell-of-origin specific exosomes can be used to determine treatment regimens for diseases, conditions, disease stages, and stages of a condition, and can also be used to determine treatment efficacy. Markers from cell-of-origin specific exosomes can also be used to identify conditions of diseases of unknown origin.
    Type: Application
    Filed: November 12, 2009
    Publication date: July 22, 2010
    Applicant: Caris MPI, Inc.
    Inventors: Michael Klass, Christine Kuslich, George Poste
  • Publication number: 20100113290
    Abstract: Methods and compositions for the characterizing of cancers by assessing RNA levels, such as determining an RNA pattern, are provided herein. The diagnosis, prognosis, monitoring and treatment or a cancer can be determined by detecting one or more RNAs, such as microRNAs.
    Type: Application
    Filed: October 30, 2009
    Publication date: May 6, 2010
    Applicant: Caris MPI, Inc.
    Inventors: Michael KLASS, Christine Kuslich, George Poste