Patents by Inventor Christine L. Brakel

Christine L. Brakel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modified nucleotide compounds
    Patent number: 7495088
    Abstract: Disclosed is a nuclease resistant nucleotide compound capable of hybridizing with a complementary RNA in a manner which inhibits the function thereof, which modified nucleotide compound includes at least one component selected from the group consisting of MN3M, B(N)xM and M(N)xB wherein N is a phosphodiester-linked modified 2?-deoxynucleoside moiety; M is a moiety that confers endonuclease resistance on said component and that contains at least one modified or unmodified nucleic acid base; B is a moiety that confers exonuclease resistance to the terminus to which it is attached; and x is an integer of at least 2.
    Type: Grant
    Filed: June 28, 1994
    Date of Patent: February 24, 2009
    Assignee: Enzo Life Sciences, Inc.
    Inventors: Christine L. Brakel, James G. Wetmur, Robin S. Quartin
  • End labeled nucleotide probe
    Patent number: 5082830
    Abstract: An oligo- or polynucleotide having at least one biotin directly or indirectly attached to each of the 5' and 3' end nucleotides thereof and a nucleic acid hybridization assay system for use therewith. The biotins are optionally attached through linkage groups that do not interfere with hybridization. The biotins can further serve to attach a biotinylated polymer.
    Type: Grant
    Filed: February 26, 1988
    Date of Patent: January 21, 1992
    Assignee: Enzo Biochem, Inc.
    Inventors: Christine L. Brakel, Alan F. Cook, Edmund Vuocolo