Patents by Inventor Christine L. Rebbeck
Christine L. Rebbeck has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11833108Abstract: A sterile solution product bag for lyophilizing includes a bladder, a first stem having a first stem inlet end and a first stem outlet end. The first stem outlet end is fluidly connected to the bladder and the first stem inlet end is adapted to receive a liquid. A first filter is disposed in-line with the first stem and includes a first filter membrane, a first filter open end, and a first filter closed end. The first filter closed end is disposed between the first stem inlet end and the first stem outlet end and the first filter open end is disposed in proximity to the first stem inlet end. A second stem having a second stem inlet end fluidly connected to the bladder and a second stem outlet end adapted to receive a vapor. A second filter is disposed within the second stem and includes a filter membrane.Type: GrantFiled: July 12, 2018Date of Patent: December 5, 2023Assignees: BAXTER INTERNATIONAL INC., BAXTER HEALTHCARE SAInventors: Mark Joseph Doty, Christine L. Rebbeck, Sydney Jean Cope, William Spencer Hurst, Grant Anthony Bomgaars, Yuanpang Samuel Ding, Thomas Edward Dudar, Ying-Cheng Lo, Mark Edward Pasmore, Michael Joseph Sadowski, Anastasios Hristakos, Joseph Vincent Ranalletta, Bernd Krause
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Publication number: 20200146931Abstract: A sterile solution product bag for lyophilizing includes a bladder, a first stem having a first stem inlet end and a first stem outlet end. The first stem outlet end is fluidly connected to the bladder and the first stem inlet end is adapted to receive a liquid. A first filter is disposed in-line with the first stem and includes a first filter membrane, a first filter open end, and a first filter closed end. The first filter closed end is disposed between the first stem inlet end and the first stem outlet end and the first filter open end is disposed in proximity to the first stem inlet end. A second stem having a second stem inlet end fluidly connected to the bladder and a second stem outlet end adapted to receive a vapor. A second filter is disposed within the second stem and includes a filter membrane.Type: ApplicationFiled: July 12, 2018Publication date: May 14, 2020Inventors: Mark Joseph. Doty, Christine L. Rebbeck, Sydney Jean Cope, William Spencer Hurst, Grant Anthony Bomgaars, Yuanpang Samuel Ding, Thomas Edward Dudar, Ying-Cheng Lo, Mark Edward Pasmore, Michael Joseph Sadowski, Anastasios Hristakos, Joseph Vincent Ranalletta, Bernd Krause
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Publication number: 20180169180Abstract: An aqueous pharmaceutical composition suitable for parenteral administration and having enhanced storage stability includes between about 0.1 mg/mL and about 40 mg/mL micafungin; (ii) between about 0.1 mM and 400 mM buffering agent; and (iii) between about 0 mg/mL and about 500 mg/mL tonicity adjusting agent, wherein the pH of the composition is between about 3.0 and 7.0, for example, between about 3.5 and 7.0.Type: ApplicationFiled: December 15, 2017Publication date: June 21, 2018Inventors: Sydney J. Cope, Christine L. Rebbeck, Mark J. Doty
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Patent number: 9625210Abstract: This application discloses devices, articles, and methods useful for producing lyophilized cakes of solutes. The devices and articles provide for a method of freezing liquid solutions of the solute by the top and the bottom of the solution simultaneously and at approximately the same rate. The as frozen solution can then provide a lyophilized cake of the solutes with large and uniform pores.Type: GrantFiled: November 17, 2014Date of Patent: April 18, 2017Assignees: BAXTER INTERNATIONAL INC., BAXTER HEALTHCARE SAInventors: Wei-Youh Kuu, Mark J. Doty, William S. Hurst, Christine L. Rebbeck
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Patent number: 9528761Abstract: This application discloses devices, articles, and methods useful for producing lyophilized cakes of solutes. The devices and articles provide for a method of freezing liquid solutions of the solute by the top and the bottom of the solution simultaneously and at approximately the same rate. The as frozen solution can then provide a lyophilized cake of the solutes with large and uniform pores.Type: GrantFiled: April 20, 2015Date of Patent: December 27, 2016Assignees: BAXTER INTERNATIONAL INC., BAXTER HEALTHCARE SAInventors: Wei-Youh Kuu, Mark Doty, William S. Hurst, Christine L. Rebbeck
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Publication number: 20150226480Abstract: This application discloses devices, articles, and methods useful for producing lyophilized cakes of solutes. The devices and articles provide for a method of freezing liquid solutions of the solute by the top and the bottom of the solution simultaneously and at approximately the same rate. The as frozen solution can then provide a lyophilized cake of the solutes with large and uniform pores.Type: ApplicationFiled: April 20, 2015Publication date: August 13, 2015Inventors: Wei-Youh Kuu, Mark Doty, William S. Hurst, Christine L. Rebbeck
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Publication number: 20150184935Abstract: This application discloses devices, articles, and methods useful for producing lyophilized cakes of solutes. The devices and articles provide for a method of freezing liquid solutions of the solute by the top and the bottom of the solution simultaneously and at approximately the same rate. The as frozen solution can then provide a lyophilized cake of the solutes with large and uniform pores.Type: ApplicationFiled: November 17, 2014Publication date: July 2, 2015Inventors: Wei-Youh Kuu, Mark J. Doty, William S. Hurst, Christine L. Rebbeck
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Patent number: 8966782Abstract: This application discloses devices, articles, and methods useful for producing lyophilized cakes of solutes. The devices and articles provide for a method of freezing liquid solutions of the solute by the top and the bottom of the solution simultaneously and at approximately the same rate. The as frozen solution can then provide a lyophilized cake of the solutes with large and uniform pores.Type: GrantFiled: March 28, 2012Date of Patent: March 3, 2015Assignees: Baxter International Inc., Baxter Healthcare SAInventors: Wei-Youh Kuu, Mark J. Doty, William S. Hurst, Christine L. Rebbeck
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Patent number: 8263131Abstract: The present invention relates to compositions of submicron- to micron-size particles of antimicrobial agents. More particularly the invention relates to a composition of an antimicrobial agent that renders the agent potent against organisms normally considered to be resistant to the agent. The composition comprises an aqueous suspension of submicron- to micron-size particles containing the agent coated with at least one surfactant selected from the group consisting of: ionic surfactants, non-ionic surfactants, biologically derived surfactants, and amino acids and their derivatives. The particles have a volume-weighted mean particle size of less than 5 ?m as measured by laser diffractometry.Type: GrantFiled: March 30, 2009Date of Patent: September 11, 2012Assignees: Baxter International Inc., Baxter Healthcare S.A.Inventors: Barrett Rabinow, Randy White, Chong-Son Sun, Joseph Chung Take Wong, James E. Kipp, Mark Doty, Christine L. Rebbeck, Pavlos Papadopoulos
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Publication number: 20120192448Abstract: This application discloses devices, articles, and methods useful for producing lyophilized cakes of solutes. The devices and articles provide for a method of freezing liquid solutions of the solute by the top and the bottom of the solution simultaneously and at approximately the same rate. The as frozen solution can then provide a lyophilized cake of the solutes with large and uniform pores.Type: ApplicationFiled: March 28, 2012Publication date: August 2, 2012Applicants: BAXTER HEALTHCARE S.A, BAXTER INTERNATIONAL INC.Inventors: Wei-Youh Kuu, Mark J. Doty, William S. Hurst, Christine L. Rebbeck
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Patent number: 7193084Abstract: The present invention provides a polymorphic form of itraconazole.Type: GrantFiled: August 5, 2002Date of Patent: March 20, 2007Assignee: Baxter International Inc.Inventors: Jane Werling, Mark J. Doty, Christine L. Rebbeck, Joseph Chung Tak Wong, James E. Kipp
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Patent number: 7112340Abstract: The present invention discloses a composition of a stable suspension of a poorly water soluble pharmaceutical agent or cosmetic in the form of particles of the pharmaceutical agent or cosmetic suspended in a frozen aqueous matrix and method for its preparation. The composition is stable for a prolonged period of time, preferably six months or longer and is suitable for parenteral, oral, or non-oral routes such as pulmonary (inhalation), ophthalmic, or topical administration.Type: GrantFiled: October 11, 2002Date of Patent: September 26, 2006Assignee: Baxter International Inc.Inventors: James E. Kipp, Mark J. Doty, Christine L. Rebbeck, Sean Brynjelsen, Jamie Teresa Konkel
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Patent number: 7067143Abstract: A premix parenteral solution for intravenous administration having amiodarone, as an active ingredient, solubilized in a solution of water for injection and about 0.4-12 mg/ml of a non-ionic surfactant to a concentration range of from 0.2 to 6 mg/ml is disclosed. The solution optionally may include an osmotic agent. No dilution of the solution is required before administering to a patient and the sterile packaged solution has an initial pH within the range of from about 2.9 to about 3.2, preferably about 3.1. Additionally, a method for producing an amiodarone solution suitable for intravenous administration is further disclosed.Type: GrantFiled: August 31, 2001Date of Patent: June 27, 2006Assignee: Baxter International, Inc.Inventors: Mark J. Doty, Christine L. Rebbeck, James E. Kipp, Neervalur V. Raghavan
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Patent number: 7037528Abstract: The present invention provides a method for preparing submicron sized particles of an organic compound, the solubility of which is greater in a water-miscible first solvent than in a second solvent which is aqueous, the process including the steps of: (i) dissolving the organic compound in the water-miscible first solvent to form a solution, (ii) mixing the solution with the second solvent to define a pre-suspension; and (iii) adding energy to the pre-suspension to form particles having an average effective particle size of 400 nm to 2 microns.Type: GrantFiled: June 5, 2001Date of Patent: May 2, 2006Assignee: Baxter International Inc.Inventors: James E. Kipp, Joseph Chung Tak Wong, Mark J. Doty, Christine L. Rebbeck
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Patent number: 6951656Abstract: The present invention provides a method for preparing submicron sized particles of an organic compound, the solubility of which is greater in a water-miscible first solvent than in a second solvent which is aqueous, the process including the steps of: (i) dissolving the organic compound in the water-miscible first solvent to form a solution, (ii) mixing the solution with the second solvent to define a pre-suspension; and (iii) adding energy to the pre-suspension to form particles having an average effective particle size of less than about 2 ?m.Type: GrantFiled: September 17, 2001Date of Patent: October 4, 2005Assignee: Baxter International Inc.Inventors: James E. Kipp, Joseph Chung Tak Wong, Mark J. Doty, Christine L. Rebbeck, Sean Brynjelsen
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Patent number: 6884436Abstract: The present invention provides a method for preparing a suspension of a pharmaceutically-active compound, the solubility of which is greater in a water-miscible first organic solvent than in a second solvent which is aqueous. The process includes the steps of: (i) dissolving a first quantity of the pharmaceutically-active compound in the water-miscible first organic solvent to form a first solution; (ii) mixing the first solution with the second solvent to precipitate the pharmaceutically-active compound; and (iii) seeding the first solution or the second solvent or the pre-suspension.Type: GrantFiled: December 12, 2001Date of Patent: April 26, 2005Assignee: Baxter International Inc.Inventors: James E. Kipp, Joseph Chung Tak Wong, Mark J. Doty, Jane Werling, Christine L. Rebbeck, Sean Brynjelsen
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Patent number: 6869617Abstract: The present invention provides a method for preparing submicron sized particles of an organic compound, the solubility of which is greater in a water-miscible first solvent than in a second solvent which is aqueous, the process including the steps of: (i) dissolving the organic compound in the water-miscible first solvent to form a solution, (ii) mixing the solution with the second solvent to define a pre-suspension; and (iii) adding energy to the pre-suspension to form particles having an average effective particle size of 400 nm to 2 microns.Type: GrantFiled: June 5, 2001Date of Patent: March 22, 2005Assignee: Baxter International Inc.Inventors: James E. Kipp, Joseph Chung Tak Wong, Mark J. Doty, Christine L. Rebbeck
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Publication number: 20040022862Abstract: The present invention is concerned with the formation of small particles of organic compounds by precipitating the organic compounds in an aqueous medium to form a pre-suspension followed by adding energy to stabilize a coating of the particle or to alter the lattice structure of the particle. The process includes the steps of: (i) dissolving the organic compound in the water-miscible first solvent to form a solution; (ii) mixing the solution with the second solvent to define a presuspension of particles; and (iii) adding energy to the presuspension to form a suspension of particles having an average effective particle size of less than about 100 &mgr;m. The process is preferably used to prepare a suspension of small particles of a poorly water-soluble, pharmaceutically active compound suitable for in vivo delivery by an administrate route such as parenteral, oral, pulmonary, nasal, buccal, topical ophthalmic, rectal, vaginal, transdermal or the like.Type: ApplicationFiled: March 17, 2003Publication date: February 5, 2004Inventors: James E. Kipp, Joseph Chung Tak Wong, Mark J. Doty, Jane Werling, Christine L. Rebbeck, Sean Brynjelsen
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Publication number: 20030206959Abstract: The present invention provides a method for preparing a suspension of a pharmaceutically-active compound, the solubility of which is greater in a water-miscible first organic solvent than in a second solvent which is aqueous. The process includes the steps of: (i) dissolving a first quantity of the pharmaceutically-active compound in the water-miscible first organic solvent to form a first solution; (ii) mixing the first solution with the second solvent to precipitate the pharmaceutically-active compound; and (iii) seeding the first solution or the second solvent or the pre-suspension.Type: ApplicationFiled: December 12, 2001Publication date: November 6, 2003Inventors: James E. Kipp, Joseph Chung Tak Wong, Mark J. Doty, Jane Werling, Christine L. Rebbeck, Sean Brynjelsen
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Patent number: 6607784Abstract: The present invention provides a method for preparing submicron sized particles of an organic compound, the solubility of which is greater in a water-miscible first solvent than in a second solvent which is aqueous, the process including the steps of (i) dissolving the organic compound in the water-miscible first solvent to form a solution, (ii) mixing the solution with the second solvent to define a pre-suspension; and (iii) adding energy to the pre-suspension to form particles having an average effective particle size of 400 nm to 2 microns.Type: GrantFiled: June 5, 2001Date of Patent: August 19, 2003Assignee: Baxter International Inc.Inventors: James E. Kipp, Joseph Chung Tak Wong, Mark J. Doty, Christine L. Rebbeck