Patents by Inventor Christine Lynne Pitner
Christine Lynne Pitner has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10494627Abstract: A system for extracting material from a region of interest includes a fluid delivery base comprising an inlet channel and an outlet channel formed within the fluid delivery base, a gasket affixed to the fluid delivery base, wherein the gasket comprises at least one opening exposing an open end of the inlet channel and an open end of the outlet channel; a support comprising a sample-supporting surface facing the gasket and an opposing surface; and an alignment member coupled to the opposing surface in a fixed position and such that the support is positioned between the fluid delivery base and the alignment member, wherein one or both of the alignment member or the fluid delivery base are biased towards one another by a force (e.g., a magnet or spring force) and wherein the fluid delivery base is separable from the support and configured to move along a plane of the sample-supporting surface to align with the alignment member.Type: GrantFiled: March 8, 2017Date of Patent: December 3, 2019Assignee: General Electric CompanyInventors: John Richard Nelson, Wei Gao, Christopher Michael Puleo, Todd Frederick Miller, Christine Lynne Pitner, David Andrew Shoudy, Alex David Corwin
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Patent number: 9797767Abstract: Approaches are disclosed for calibrating a plurality of imaging devices, such as microscopes. In certain implementations, a calibration plate is employed that include a variety of calibration features. Imaging devices calibrated in accordance with the present approaches may be used to generate images having consistent attributes, such as brightness, regardless of which imaging device is employed.Type: GrantFiled: August 26, 2014Date of Patent: October 24, 2017Assignee: General Electric CompanyInventors: Alex David Corwin, Christine Lynne Pitner, David Andrew Shoudy, Kevin Bernard Kenny
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Publication number: 20170175105Abstract: A system for extracting material from a region of interest includes a fluid delivery base comprising an inlet channel and an outlet channel formed within the fluid delivery base, a gasket affixed to the fluid delivery base, wherein the gasket comprises at least one opening exposing an open end of the inlet channel and an open end of the outlet channel; a support comprising a sample-supporting surface facing the gasket and an opposing surface; and an alignment member coupled to the opposing surface in a fixed position and such that the support is positioned between the fluid delivery base and the alignment member, wherein one or both of the alignment member or the fluid delivery base are biased towards one another by a force (e.g., a magnet or spring force) and wherein the fluid delivery base is separable from the support and configured to move along a plane of the sample-supporting surface to align with the alignment member.Type: ApplicationFiled: March 8, 2017Publication date: June 22, 2017Inventors: John Richard Nelson, Wei Gao, Christopher Michael Puleo, Todd Frederick Miller, Christine Lynne Pitner, David Andrew Shoudy, Alex David Corwin
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Patent number: 9625355Abstract: A system for extracting material from a region of interest includes a fluid delivery base comprising an inlet channel and an outlet channel formed within the fluid delivery base; a gasket affixed to the fluid delivery base, wherein the gasket comprises at least one opening exposing an open end of the inlet channel and an open end of the outlet channel; a support comprising a sample-supporting surface facing the gasket and an opposing surface; and an alignment member coupled to the opposing surface in a fixed position and such that the support is positioned between the fluid delivery base and the alignment member, wherein one or both of the alignment member or the fluid delivery base are biased towards one another by a force (e.g., a magnet or spring force) and wherein the fluid delivery base is separable from the support and configured to move along a plane of the sample-supporting surface to align with the alignment member.Type: GrantFiled: December 1, 2014Date of Patent: April 18, 2017Assignee: GENERAL ELECTRIC COMPANYInventors: John Richard Nelson, Wei Gao, Christopher Michael Puleo, Todd Frederick Miller, Christine Lynne Pitner, David Andrew Shoudy, Alex David Corwin
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Patent number: 9581800Abstract: The invention provides a slide holder that utilizes edge detection algorithms to determine the location of various edges of a slide. From these edges, and integrating characteristic slide dimension, both linear offset of the edge of the slide in the holder and any rotation of the slide relative to the microscope stage axis are determined. The process of using the slide holder of the invention ensures precise and accurate placement of a slide during a first round of imaging and for reload in subsequent rounds.Type: GrantFiled: November 21, 2014Date of Patent: February 28, 2017Assignee: General Electric CompanyInventors: Alex David Corwin, Kevin Bernard Kenny, Christine Lynne Pitner
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Publication number: 20160153868Abstract: A system for extracting material from a region of interest includes a fluid delivery base comprising an inlet channel and an outlet channel formed within the fluid delivery base; a gasket affixed to the fluid delivery base, wherein the gasket comprises at least one opening exposing an open end of the inlet channel and an open end of the outlet channel; a support comprising a sample-supporting surface facing the gasket and an opposing surface; and an alignment member coupled to the opposing surface in a fixed position and such that the support is positioned between the fluid delivery base and the alignment member, wherein one or both of the alignment member or the fluid delivery base are biased towards one another by a force (e.g., a magnet or spring force) and wherein the fluid delivery base is separable from the support and configured to move along a plane of the sample-supporting surface to align with the alignment member.Type: ApplicationFiled: December 1, 2014Publication date: June 2, 2016Inventors: John Richard Nelson, Wei Gao, Christopher Michael Puleo, Todd Frederick Miller, Christine Lynne Pitner, David Andrew Shoudy, Alex David Corwin
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Publication number: 20160147056Abstract: The invention provides a slide holder that utilizes edge detection algorithms to determine the location of various edges of a slide. From these edges, and integrating characteristic slide dimension, both linear offset of the edge of the slide in the holder and any rotation of the slide relative to the microscope stage axis are determined. The process of using the slide holder of the invention ensures precise and accurate placement of a slide during a first round of imaging and for reload in subsequent rounds.Type: ApplicationFiled: November 21, 2014Publication date: May 26, 2016Inventors: Alex David Corwin, Kevin Bernard Kenny, Christine Lynne Pitner
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Publication number: 20160061654Abstract: Approaches are disclosed for calibrating a plurality of imaging devices, such as microscopes. In certain implementations, a calibration plate is employed that include a variety of calibration features. Imaging devices calibrated in accordance with the present approaches may be used to generate images having consistent attributes, such as brightness, regardless of which imaging device is employed.Type: ApplicationFiled: August 26, 2014Publication date: March 3, 2016Inventors: Alex David Corwin, Christine Lynne Pitner, David Andrew Shoudy, Kevin Bernard Kenny
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Patent number: 9150907Abstract: A microfluidic flow cell subassembly, which may be assembled into a flow cell having fluidic connections outside of the main substrate, is described for encapsulating a sample to allow for subsequent controlled delivery of reagents to the sample, such as multiplexed in situ biomarker staining and analysis. The fluidic connectors are thin film fluidic connectors capable of connecting to a fluid delivery system. The subassembly may be sealed against a solid support to form a flow cell. Methods of use are also disclosed.Type: GrantFiled: May 15, 2014Date of Patent: October 6, 2015Assignee: General Electric CompanyInventors: Kashan Ali Shaikh, Mengli Wang, Adriana Ines Larriera Moreno, Jessica Godin Karp, Christine Lynne Pitner
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Publication number: 20150198580Abstract: The invention provides a coverslip for automated decoverslipping of a tissue bearing slide comprising a horizontal base portion having a length, width, and height, at least two side wall portions extending downward from opposite sides of the base portion each having a length and width and h; and wherein the total wall volume to base volume ratio is greater than or equal to approximately 0.025.Type: ApplicationFiled: January 13, 2014Publication date: July 16, 2015Applicant: GENERAL ELECTRIC COMPANYInventors: Brian James Grimmond, Brian Christopher Bales, Alex David Corwin, Adriana Ines Larriera Moreno, Christine Lynne Pitner
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Patent number: 9080941Abstract: A microfluidic flow cell subassembly, which may be assembled into a flow cell having fluidic connections outside of the main substrate, is described for encapsulating a sample to allow for subsequent controlled delivery of reagents to the sample, such as multiplexed in situ biomarker staining and analysis. As configured, the subassembly comprises a substrate layer forms a flexible optically transparent lid which is capable of bending in either direction to alter the internal dimensions of the subassembly. Methods of use are also disclosed.Type: GrantFiled: May 14, 2014Date of Patent: July 14, 2015Assignee: General Electric CompanyInventors: Kashan Ali Shaikh, Mengli Wang, Adriana Ines Larriera Moreno, Jessica Godin Karp, Christine Lynne Pitner
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Publication number: 20140248617Abstract: A microfluidic flow cell subassembly, which may be assembled into a flow cell having fluidic connections outside of the main substrate, is described for encapsulating a sample to allow for subsequent controlled delivery of reagents to the sample, such as multiplexed in situ biomarker staining and analysis. As configured, the subassembly comprises a substrate layer forms a flexible optically transparent lid which is capable of bending in either direction to alter the internal dimensions of the subassembly. Methods of use are also disclosed.Type: ApplicationFiled: May 14, 2014Publication date: September 4, 2014Applicant: GENERAL ELECTRIC COMPANYInventors: Kashan Ali Shaikh, Mengli Wang, Adriana Ines Larriera Moreno, Jessica Godin Karp, Christine Lynne Pitner
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Publication number: 20140248618Abstract: A microfluidic flow cell subassembly, which may be assembled into a flow cell having fluidic connections outside of the main substrate, is described for encapsulating a sample to allow for subsequent controlled delivery of reagents to the sample, such as multiplexed in situ biomarker staining and analysis. The fluidic connectors are thin film fluidic connectors capable of connecting to a fluid delivery system. The subassembly may be sealed against a solid support to form a flow cell. Methods of use are also disclosed.Type: ApplicationFiled: May 15, 2014Publication date: September 4, 2014Applicant: GENERAL ELECTRIC COMPANYInventors: Kashan Ali Shaikh, Mengli Wang, Adriana Ines Larriera Moreno, Jessica Godin Karp, Christine Lynne Pitner