Patents by Inventor Christine Lynne Surrette
Christine Lynne Surrette has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11826760Abstract: A fluidic handling unit includes a baseplate, a fluidic inlet block, a fluidic outlet block, a pump in fluidic communication with the fluidic inlet block and the fluidic outlet block, a carrier control board in electrical communication with the pump, and a flow cell carrier comprising a microfluidic flow cell receiving area, wherein the flow cell carrier is configured to receive and retain the fluidic handling unit. A bottom surface of the fluidic handling unit is configured to complementary mate with a top surface of the flow cell carrier, or wherein a bottom surface of the flow cell carrier is configured to complementarily mate with a top surface of the fluidic handling unit.Type: GrantFiled: July 15, 2022Date of Patent: November 28, 2023Assignee: LEICA MICROSYSTEMS CMS GMBHInventors: Meret Vollenweider, Stephen Eric Zingelewicz, Alex David Corwin, Kashan Ali Shaikh, Jessica Godin Karp, Michael Steven Lazare, David Andrew Shoudy, Christine Lynne Surrette
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Patent number: 11821891Abstract: A device and/or methodology are described that include a mechanism for separating erythrocytes from other constituents of blood and for purifying leukocytes from blood. The separation and purification aspects may be provided in separate components or within the same component. The separation aspect assists in separating erythrocytes (red blood cells) from other cells in blood, such as by aggregation of the red blood cells. A suitable aggregation device or device component uses chambers with at least one small dimension (e.g., a microfluidic chip) to control the interaction of the blood with a solution containing a high molecular weight polymer (e.g., dextran) to achieve separation.Type: GrantFiled: December 7, 2020Date of Patent: November 21, 2023Assignee: General Electric CompanyInventors: Jessica Godin Karp, Xiaohui Chen, Kashan Ali Shaikh, Mengli Wang, Ralf Lenigk, Christine Lynne Surrette
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Patent number: 11597960Abstract: The present disclosure relates to approaches for assessing a sample or the presence of microorganisms. The sample, in certain implementations may be assessed for one or both of absence of microorganisms (sterility) and/or for concentration of said organisms (bio-burden). sample partition device may be employed that partitions the sample input volume into multiple discrete measurement zones with little or no loss of sample (e.g., zero-loss) and with little operator involvement, thereby reducing operator- and environment-based false positives.Type: GrantFiled: July 1, 2019Date of Patent: March 7, 2023Assignee: General Electric CompanyInventors: Alex David Corwin, Erik Leeming Kvam, Christine Lynne Surrette, Brian Joseph Scherer, Pei-Hsin Kuo, Ralf Lenigk
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Patent number: 11590502Abstract: The present disclosure relates to a consumable sample partition device and it assembly and use. The sample partition device can be used to test a sample for absence of microorganisms (sterility) and/or for concentration of said organisms (bio-burden). The sample partition device partitions the sample input volume into multiple discrete measurement zones with little or no loss of sample (e.g., zero-loss) and with little operator involvement, thereby reducing operator- and environment-based false positives.Type: GrantFiled: July 1, 2019Date of Patent: February 28, 2023Assignee: General Electric CompanyInventors: Alex David Corwin, Erik Leeming Kvam, Christine Lynne Surrette, Brian Joseph Scherer, Pei-Hsin Kuo, Ralf Lenigk, Tyler John Hammond
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Publication number: 20220347691Abstract: A fluidic handling unit includes a baseplate, a fluidic inlet block, a fluidic outlet block, a pump in fluidic communication with the fluidic inlet block and the fluidic outlet block, a carrier control board in electrical communication with the pump, and a flow cell carrier comprising a microfluidic flow cell receiving area, wherein the flow cell carrier is configured to receive and retain the fluidic handling unit. A bottom surface of the fluidic handling unit is configured to complementary mate with a top surface of the flow cell carrier, or wherein a bottom surface of the flow cell carrier is configured to complementarily mate with a top surface of the fluidic handling unit.Type: ApplicationFiled: July 15, 2022Publication date: November 3, 2022Inventors: Meret Vollenweider, Stephen Eric Zingelewicz, Alex David Corwin, Kashan Ali Shaikh, Jessica Godin Karp, Michael Steven Lazare, David Andrew Shoudy, Christine Lynne Surrette
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Patent number: 11446671Abstract: Systems and methods for processing biological specimens are provided. The biological specimen processing system generally includes a flow cell carrier for holding a microfluidic flow cell and a fluidic handling unit attachable to the flow cell carrier. The fluidic handling unit interfaces with the microfluidic flow cell and can include fluidic pumps, fluidic connections, integrated electronics, and processing software to facilitate processing of a biological specimen contained in the microfluidic flow cell.Type: GrantFiled: March 14, 2017Date of Patent: September 20, 2022Assignee: LEICA MICROSYSTEMS CMS GMBHInventors: Meret Vollenweider, Stephen Eric Zingelewicz, Alex David Corwin, Kashan Ali Shaikh, Jessica Godin Karp, Michael Steven Lazare, David Andrew Shoudy, Christine Lynne Surrette
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Publication number: 20220065757Abstract: The present invention relates to a microfluidic device 100 for image multiplexing. The microfluidic device 100 comprises a base structure 110 comprising an optical window 140 and a fluid well insert 120 coupled to the base structure 110. The fluid well insert 120 is configured to retain a microscope slide 130 for mounting of a biological sample 150 within the microfluidic device 100. The fluid well insert 120 is also configured to provide a fluid to said biological sample 150. A fluid well insert lid 160 coupled to the fluid well insert 120 is also provided.Type: ApplicationFiled: August 28, 2020Publication date: March 3, 2022Inventors: Alex David Corwin, John Tenny Fogelberg, Christine Lynne Surrette, Elizabeth McDonough, Tyler Hammond, Sara Peterson
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Publication number: 20220062898Abstract: A microfluidic device for image multiplexing includes a base structure and a fluid well insert. The base structure comprises an optical window. The fluid well insert configured to be coupled to the base structure and to retain a microscope slide for mounting a biological sample within the microfluidic device. The fluid well insert is further configured to provide a fluid to the biological sample. A fluid well insert lid is coupled to the fluid well insert or the fluid well insert comprises a fluid well insert lid.Type: ApplicationFiled: February 2, 2021Publication date: March 3, 2022Inventors: Alex David Corwin, John Tenny Fogelberg, Christine Lynne Surrette, Elizabeth McDonough, Tyler Hammond, Sara Peterson, Joseph Allen Unwin
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Publication number: 20210088503Abstract: A device and/or methodology are described that include a mechanism for separating erythrocytes from other constituents of blood and for purifying leukocytes from blood. The separation and purification aspects may be provided in separate components or within the same component. The separation aspect assists in separating erythrocytes (red blood cells) from other cells in blood, such as by aggregation of the red blood cells. A suitable aggregation device or device component uses chambers with at least one small dimension (e.g., a microfluidic chip) to control the interaction of the blood with a solution containing a high molecular weight polymer (e.g., dextran) to achieve separation.Type: ApplicationFiled: December 7, 2020Publication date: March 25, 2021Inventors: Jessica Godin Karp, Xiaohui Chen, Kashan Ali Shaikh, Mengli Wang, Ralf Lenigk, Christine Lynne Surrette
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Publication number: 20210001336Abstract: The present disclosure relates to a consumable sample partition device and it assembly and use. The sample partition device can be used to test a sample for absence of microorganisms (sterility) and/or for concentration of said organisms (bio-burden). The sample partition device partitions the sample input volume into multiple discrete measurement zones with little or no loss of sample (e.g., zero-loss) and with little operator involvement, thereby reducing operator- and environment-based false positives.Type: ApplicationFiled: July 1, 2019Publication date: January 7, 2021Inventors: Alex David Corwin, Erik Leeming Kvam, Christine Lynne Surrette, Brian Joseph Scherer, Pei-Hsin Kuo, Ralf Lenigk, Tyler John Hammond
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Publication number: 20210002688Abstract: The present disclosure relates to approaches for assessing a sample or the presence of microorganisms. The sample, in certain implementations may be assessed for one or both of absence of microorganisms (sterility) and/or for concentration of said organisms (bio-burden). sample partition device may be employed that partitions the sample input volume into multiple discrete measurement zones with little or no loss of sample (e.g., zero-loss) and with little operator involvement, thereby reducing operator- and environment-based false positives.Type: ApplicationFiled: July 1, 2019Publication date: January 7, 2021Inventors: Alex David Corwin, Erik Leeming Kvam, Christine Lynne Surrette, Brian Joseph Scherer, Pei-Hsin Kuo, Ralf Lenigk
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Patent number: 10859563Abstract: A device and/or methodology are described that include a mechanism for separating erythrocytes from other constituents of blood and for purifying leukocytes from blood. The separation and purification aspects may be provided in separate components or within the same component. The separation aspect assists in separating erythrocytes (red blood cells) from other cells in blood, such as by aggregation of the red blood cells. A suitable aggregation device or device component uses chambers with at least one small dimension (e.g., a microfluidic chip) to control the interaction of the blood with a solution containing a high molecular weight polymer (e.g., dextran) to achieve separation.Type: GrantFiled: December 1, 2015Date of Patent: December 8, 2020Assignee: GENERAL ELECTRIC COMPANYInventors: Jessica Godin Karp, Xiaohui Chen, Kashan Ali Shaikh, Mengli Wang, Ralf Lenigk, Christine Lynne Surrette
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Patent number: 10787695Abstract: A system includes a bacteria culture array that includes a plurality of chambers each configured to receive a portion of a sample that includes bacteria. Each individual chamber of the plurality of chambers includes a chamber opening configured to permit access of the portion of the sample to the individual chamber. The system also includes one or more sensors configured to collect data from the individual chamber. The sensors are configured to contact the sample. Additionally, the system includes a monitoring and analysis system that includes a processor configured to receive the data from the one or more sensors at a first time and a second time, compare the data received at the second time to the data received at the first time, and identify a portion of the plurality of chambers of the bacteria culture array based on the comparing.Type: GrantFiled: June 1, 2017Date of Patent: September 29, 2020Assignee: General Electric CompanyInventors: Christopher Michael Puleo, Christine Lynne Surrette, Erik Leeming Kvam, Steven Yuehin Go, Feng Chen, John Richard Nelson, Craig Patrick Galligan, Radislav Alexandrovich Potyrailo, Gregory Andrew Grossmann
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Patent number: 10746980Abstract: Approaches are disclosed for calibrating a plurality of imaging devices, such as microscopes. In certain implementations, a calibration plate is employed that includes a variety of calibration features. The calibration features comprise a geometric calibration, an illumination calibration, and an optical calibration. Imaging devices calibrated in accordance with the present approaches may be used to generate images having consistent attributes, such as brightness, regardless of which imaging device is employed.Type: GrantFiled: November 6, 2015Date of Patent: August 18, 2020Assignee: General Electric CompanyInventors: Kevin Bernard Kenny, Alex David Corwin, David Andrew Shoudy, Christine Lynne Surrette
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Publication number: 20190091696Abstract: Systems and methods for processing biological specimens are provided. The biological specimen processing system generally includes a flow cell carrier for holding a microfluidic flow cell and a fluidic handling unit attachable to the flow cell carrier. The fluidic handling unit interfaces with the microfluidic flow cell and can include fluidic pumps, fluidic connections, integrated electronics, and processing software to facilitate processing of a biological specimen contained in the microfluidic flow cell.Type: ApplicationFiled: March 14, 2017Publication date: March 28, 2019Inventors: Meret Vollenweider, Stephen Eric Zingelewicz, Alex David Corwin, Kashan Ali Shaikh, Jessica Godin Karp, Michael Steven Lazare, David Andrew Shoudy, Christine Lynne Surrette
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Publication number: 20180345278Abstract: A system includes a bacteria culture array that includes a plurality of chambers each configured to receive a portion of a sample that includes bacteria. Each individual chamber of the plurality of chambers includes a chamber opening configured to permit access of the portion of the sample to the individual chamber. The system also includes one or more sensors configured to collect data from the individual chamber. The sensors are configured to contact the sample. Additionally, the system includes a monitoring and analysis system that includes a processor configured to receive the data from the one or more sensors at a first time and a second time, compare the data received at the second time to the data received at the first time, and identify a portion of the plurality of chambers of the bacteria culture array based on the comparing.Type: ApplicationFiled: June 1, 2017Publication date: December 6, 2018Inventors: Christopher Michael Puleo, Christine Lynne Surrette, Erik Leeming Kvam, Steven Yuehin Go, Feng Chen, John Richard Nelson, Craig Patrick Galligan, Radislav Alexandrovich Potyrailo, Gregory Andrew Grossmann
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Publication number: 20170153223Abstract: A device and/or methodology are described that include a mechanism for separating erythrocytes from other constituents of blood and for purifying leukocytes from blood. The separation and purification aspects may be provided in separate components or within the same component. The separation aspect assists in separating erythrocytes (red blood cells) from other cells in blood, such as by aggregation of the red blood cells. A suitable aggregation device or device component uses chambers with at least one small dimension (e.g., a microfluidic chip) to control the interaction of the blood with a solution containing a high molecular weight polymer (e.g., dextran) to achieve separation.Type: ApplicationFiled: December 1, 2015Publication date: June 1, 2017Inventors: Jessica Godin Karp, Xiaohui Chen, Kashan Ali Shaikh, Mengli Wang, Ralf Lenigk, Christine Lynne Surrette
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Publication number: 20160170197Abstract: Approaches are disclosed for calibrating a plurality of imaging devices, such as microscopes. In certain implementations, a calibration plate is employed that includes a variety of calibration features. The calibration features comprise a geometric calibration, an illumination calibration, and an optical calibration. Imaging devices calibrated in accordance with the present approaches may be used to generate images having consistent attributes, such as brightness, regardless of which imaging device is employed.Type: ApplicationFiled: November 6, 2015Publication date: June 16, 2016Inventors: Kevin Bernard Kenny, Alex David Corwin, David Andrew Shoudy, Christine Lynne Surrette