Abstract: The present invention is directed to compounds of Formulas (I, IIa and IIb): The invention also relates to pharmaceutical compositions comprising compounds of Formulas (I, IIa and IIb). Methods of making and using the compounds of Formulas (I, IIa and IIb) are also within the scope of the invention.

Abstract: Techniques and systems for generating ink effects for an ink stroke are described. In particular, ink gradients for digital ink strokes are provided. The described techniques allow for inking input to be transformed into a structure in which conventional and unconventional graphics techniques can be applied. A digital ink system can receive an ink stroke having ink stroke information. The outline of the ink stroke can be identified, and the ink stroke information can be transformed into surface information within the outline of the ink stroke. A graphic effect can be applied to the ink stroke using the surface information.

Abstract: Techniques and systems for applying an ink effect to the drawing of an ink stroke can include absolute age for a digital ink stroke. A digital ink system can identify a reference time from which to represent a current time. The system can generate an absolute age of each ink point of the ink stroke based on the reference time. Then the ink effect can be applied to the ink stroke with a rhythm derived from when the ink stroke was originally drawn by using the absolute age of each ink point. In some cases, the rhythm can be the same rhythm as when the ink stroke was originally drawn. In other cases, the rhythm can be modified based on the rhythm the ink stroke was originally drawn. For example, the original rhythm may be accelerating, decelerating, skewed, compressed, affine, or non-affine.

Abstract: Techniques and systems for managing visual layouts of ink strokes are described. In particular, an ink space coordinate system for a digital ink stroke is provided. A digital ink system can receive ink stroke data of an ink stroke. The system can define an ink space coordinate system along the ink stroke. Defining the ink space coordinate system can include assigning a reference line of the ink stroke and an origin point on the reference line, as well as creating ink space coordinates. Creating the ink space coordinates can include defining ink space x-coordinate values representing a distance along the reference line relative to the origin point and defining ink space y-coordinate values representing a distance along an axis perpendicular to the reference line of the ink stroke. Then the system can perform a warping to create curvature in the ink space coordinate system.

Abstract: Techniques and systems for applying an ink effect to the drawing of an ink stroke can include absolute age for a digital ink stroke. A digital ink system can identify a reference time from which to represent a current time. The system can generate an absolute age of each ink point of the ink stroke based on the reference time. Then the ink effect can be applied to the ink stroke with a rhythm derived from when the ink stroke was originally drawn by using the absolute age of each ink point. In some cases, the rhythm can be the same rhythm as when the ink stroke was originally drawn. In other cases, the rhythm can be modified based on the rhythm the ink stroke was originally drawn. For example, the original rhythm may be accelerating, decelerating, skewed, compressed, affine, or non-affine.

Abstract: Techniques and systems for generating ink effects for an ink stroke are described. In particular, ink gradients for digital ink strokes are provided. The described techniques allow for inking input to be transformed into a structure in which conventional and unconventional graphics techniques can be applied. A digital ink system can receive an ink stroke having ink stroke information. The outline of the ink stroke can be identified, and the ink stroke information can be transformed into surface information within the outline of the ink stroke. A graphic effect can be applied to the ink stroke using the surface information.

Abstract: Techniques and systems for managing visual layouts of ink strokes are described. In particular, an ink space coordinate system for a digital ink stroke is provided. A digital ink system can receive ink stroke data of an ink stroke. The system can define an ink space coordinate system along the ink stroke. Defining the ink space coordinate system can include assigning a reference line of the ink stroke and an origin point on the reference line, as well as creating ink space coordinates. Creating the ink space coordinates can include defining ink space x-coordinate values representing a distance along the reference line relative to the origin point and defining ink space y-coordinate values representing a distance along an axis perpendicular to the reference line of the ink stroke. Then the system can perform a warping to create curvature in the ink space coordinate system.