Patents by Inventor Christine Marie Blaumueller

Christine Marie Blaumueller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Human notch and delta, binding domains in toporythmic proteins, and methods based thereon
    Patent number: 5789195
    Abstract: The present invention relates to nucleotide sequences of the human Notch and Delta genes, and amino acid sequences of their encoded proteins, as well as fragments thereof containing an antigenic determinant or which are functionally active. The invention is also directed to fragments (termed herein "adhesive fragments"), and the sequences thereof, of the proteins ("toporythmic proteins") encoded by toporythmic genes which mediate homotypic or heterotypic binding to toporythmic proteins. Toporythmic genes, as used herein, refers to the genes Notch, Delta, and Serrate, as well as other members of the Delta/Serrate family which may be identified, e.g., by the methods described herein. Analogs and derivatives of the adhesive fragments which retain-binding activity are also provided. Antibodies to human Notch and to adhesive fragments are additionally provided.
    Type: Grant
    Filed: June 5, 1995
    Date of Patent: August 4, 1998
    Assignee: Yale University
    Inventors: Spyridon Artavanis-Tsakonas, Marc Alan Telander Muskavitch, Richard Grant Fehon, Ilaria Rebay, Christine Marie Blaumueller, Scott Brockwell Shepard
  • Therapeutic and diagnostic methods and compositions based on notch proteins and nucleic acids
    Patent number: 5786158
    Abstract: The present invention relates to diagnostic methods and compositions for detection of malignancy or nervous system disorders based on the level of Notch proteins or nucleic acids. Therapeutic methods and methods of inhibiting Notch expression are also provided.
    Type: Grant
    Filed: June 25, 1993
    Date of Patent: July 28, 1998
    Assignee: Yale University
    Inventors: Spyridon Artavanis-Tsakonas, Richard Grant Fehon, Panayiotis Zagouras, Christine Marie Blaumueller
  • Human Notch and Delta binding domains in toporythmic proteins, and methods based thereon
    Patent number: 5648464
    Abstract: The present invention relates to nucleotide sequences of the human Notch and Delta genes, and amino acid sequences of their encoded proteins, as well as fragments thereof containing an antigenic determinant or which are functionally active. The invention is also directed to fragments (termed herein "adhesive fragments"), and the sequences thereof, of the proteins ("toporythmic proteins") encoded by toporythmic genes which mediate homotypic or heterotypic binding to toporythmic proteins. Toporythmic genes, as used herein, refers to the genes Notch, Delta, and Serrate, as well as other members of the Delta/Serrate family which may be identified, e.g., by the methods described herein. Analogs and derivatives of the adhesive fragments which retain binding activity are also provided. Antibodies to human Notch and to adhesive fragments are additionally provided.
    Type: Grant
    Filed: June 23, 1994
    Date of Patent: July 15, 1997
    Assignee: Yale University
    Inventors: Spyridon Artavanis-Tsakonas, Richard Grant Fehon, Ilaria Rebay, Christine Marie Blaumueller