Patents by Inventor Christine Marie Paul Lambert

Christine Marie Paul Lambert has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • L-alanine derivatives as a5beta1 antagonists
    Publication number: 20080182842
    Abstract: The present invention relates to compounds that inhibit of a5b1 function, processes for their preparation, pharmaceutical compositions containing them as the active ingredient, to their use as medicaments and to their use in the manufacture of medicaments for use in the treatment in warm-blooded animals such as humans of diseases that have a significant angiogenesis or vascular component such as for treatment of solid tumours. The present invention also relates to compounds that inhibit a5b1, and also that exhibit appropriate selectivity profile(s) against other integrins.
    Type: Application
    Filed: January 29, 2008
    Publication date: July 31, 2008
    Applicant: ASTRAZENECA AB
    Inventors: Jean-Claude Arnould, Benedicte Delouvrie, Christine Marie Paul Lambert-Van Der Brempt
  • Quinazoline derivatives
    Patent number: 7115615
    Abstract: The invention concerns quinazoline derivatives of Formula (I) wherein each of m, R1, n, R2 and R3 have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an anti-invasive agent in the containment and/or treatment of solid tumour disease.
    Type: Grant
    Filed: August 15, 2001
    Date of Patent: October 3, 2006
    Assignee: AstraZeneca
    Inventors: Laurent Francois Andre Hennequin, Patrick Ple, Christine Marie Paul Lambert
  • Quinazoline derivatives
    Patent number: 6939866
    Abstract: The invention concerns quinazoline derivatives of Formula (I) wherein each of m, R1, n, R2 and R3 have any of the meanings defined in the description; process for the preparation, pharmaceutical compositions them and their use in the manufacture of a medicament for use as an anti-invasive agent in the containment and/or treatment of solid tumour disease.
    Type: Grant
    Filed: October 9, 2001
    Date of Patent: September 6, 2005
    Assignee: AstraZeneca AB
    Inventors: Christine Marie Paul Lambert, Patrick Ple
  • Quinazoline derivatives with anti-tumour activity
    Patent number: 6849625
    Abstract: The invention concerns quinazoline derivatives of Formula I wherein each of m, R1, n, R2 and R3 have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an anti-invasive agent in the containment and/or treatment of solid tumour disease.
    Type: Grant
    Filed: October 9, 2001
    Date of Patent: February 1, 2005
    Assignee: AstraZeneca AB
    Inventors: Christine Marie Paul Lambert, Patrick Ple
  • Quinazoline derivatives
    Publication number: 20040063733
    Abstract: The invention concerns quinazoline derivatives of Formula I 1
    Type: Application
    Filed: October 22, 2003
    Publication date: April 1, 2004
    Inventors: Christine Marie Paul Lambert, Patrick Ple
  • Quinazoline derivatives with anti-tumour activity
    Publication number: 20040048881
    Abstract: The invention concerns quinazoline derivatives of Formula I 1
    Type: Application
    Filed: April 8, 2003
    Publication date: March 11, 2004
    Applicant: AstraZeneca AB
    Inventors: Christine Marie Paul Lambert, Patrick Ple
  • Quinazoline derivatives
    Publication number: 20040044015
    Abstract: The invention concerns quinazoline derivatives of Formula (I) wherein each of m, R1, n, R2 and R3 have any of the meanings defined in the description; process for the preparation, pharmaceutical compositions them and their use in the manufacture of a medicament for use as an anti-invasive agent in the containment and/or treatment of solid tumour disease.
    Type: Application
    Filed: April 10, 2003
    Publication date: March 4, 2004
    Inventors: Christine Marie Paul Lambert, Patrick Ple
  • Quinazoline derivatives
    Publication number: 20040034046
    Abstract: The invention concerns quinazoline derivatives of Formula (I) wherein each of m, R1, n, R2 and R3 have any of the meanings defined in the description; processes for their preparation, pharmaceutical compositions containing them and their use in the manufacture of a medicament for use as an anti-invasive agent in the containment and/or treatment of solid tumour disease.
    Type: Application
    Filed: February 14, 2003
    Publication date: February 19, 2004
    Inventors: Laurent Francois Andre Hennequin, Patrick Ple, Christine Marie Paul Lambert
  • Therapy
    Publication number: 20030225111
    Abstract: The invention concerns the use of a quinazoline derivative of Formula (I) wherein Q1 includes a quinazoline ring optionally substituted with a group such as halogeno, trifluoromethyl and cyano, or a group of the formula: Q3—X1— wherein X1 includes a direct bond and O and Q3includes aryl, aryl-(1-6C)alkyl, heterocyclyl and heterocyclyl-(1-6C)alkyl; each of R2 and R3 is hydrogen or (1-6C)alkyl; Z includes O, S and NH; and Q2 includes aryl and aryl-(1-3C)alkyl or a pharmaceutically-acceptable salt thereof, in the manufacture of a medicament for use in the production of an antiangiogenic and/or vascular permeability reducing effect in a warm-blooded animal such as a human.
    Type: Application
    Filed: August 28, 2002
    Publication date: December 4, 2003
    Inventors: Laurent Francois Andre Hennequin, Graham Charles Crawley, Darren McKerrecher, Patrick Ple, Jeffrey Philip Poyser, Christine Marie Paul Lambert