Abstract: Provided herein is a digital care circle platform for electronic communication between a senior and virtual care circle members. The digital care circle platform may include a chatbot and an application associated with the senior, a mobile application associated with the plurality of virtual care circle members, at least one processor in communication with at least one memory device, and one or more servers, sensors, wearables, and transceivers. The at least one processor may be configured to: (i) accept event posts from the senior via the chatbot and application and from each virtual care circle member of the plurality of virtual care circle members via the mobile application, (ii) detect pro-active check-ins from the senior, and (iii) generate, once a pro-active check-in is detected, an electronic communication detailing the pro-active check-in as a pro-active check-in event, and transmit the pro-active check-in event to the virtual care circle members.

Abstract: Provided herein is an engagement and care support platform (“ECSP”) computer system including at least one processor in communication with at least one memory device for facilitating senior user engagement. The processor is programmed to: (i) register a user through an application, (ii) register a caregiver associated with the user through the application, (iii) generate a senior profile based upon user personal and scheduling data, (iv) build a daily interactive user interface that reflects the senior profile, (v) display the daily interactive user interface at a first client device associated with the user, (vi) cause the first client device to initiate a daily interaction prompt to the user, (vii) determine whether any user interaction was received in response to the daily interaction prompt, and (viii) transmit a daily update message to a second client device associated with the caregiver, including an indication of whether any user interaction was received.

Abstract: The disclosure provides for methods of predicting disease progression comprising detecting a modification of one or more disease markers in a glial cell or neuronal cell generated from a skin cell of the subject. The disclosed methods include methods of identifying subjects that are responsive to a therapeutic agent and methods of determining effectiveness of a therapeutic agent.

Abstract: The disclosure provides gene therapy vectors, such as adeno-associated virus (AAV), designed for treatment of an immunoglobulin- µ binding protein 2 (IGHMB P2)-related disorder.

Abstract: Certain embodiments of the invention provide EphA4 targeting compounds and compositions comprising a compound described herein. Certain embodiments of the invention also provide methods of treating a neurological disease (e.g., Amyotrophic Lateral Sclerosis, Alzheimer's Disease) or cancer.

Abstract: Disclosed is a method of resistance welding between composite articles. A conductive element is provided between faying surfaces, having a plurality of lower resistivity electrode portions spaced apart along the length of the contact area between the composite articles. The electrode portions can be used to spot weld across the electrode portions, and along a longitudinal portion of the conductive element between the electrode portions by application of an electrical current. Also disclosed are apparatus for use in the resistance welding methods and composite articles and structures and elements incorporating the conductive element.

Abstract: The present disclosure relates to targeting of miRNA to activate expression of genes on the inactivated X chromosome. This gene therapy is useful for treating X-linked disorders, including Rett syndrome.

Abstract: Disclosed is a method of resistance welding between composite articles. A conductive element is provided between faying surfaces, having a plurality of lower resistivity electrode portions spaced apart along the length of the contact area between the composite articles. The electrode portions can be used to spot weld across the electrode portions, and along a longitudinal portion of the conductive element between the electrode portions by application of an electrical current. Also disclosed are apparatus for use in the resistance welding methods and composite articles and structures and elements incorporating the conductive element.

Abstract: The disclosure provides gene therapy vectors, such as adeno-associated virus (AAV), designed for treatment of an Interferon regulatory factor 2 binding protein like (IRF2BPL) disorder.

Abstract: The present disclosure relates to methods of targeting specific cell types within the cochlea using optimized gene therapy vectors. In particular, the disclosure provides gene therapy vectors to specifically target cochlear cells and methods of treating hearing impairment and hearing-loss related disorders.

Abstract: Provided herein are methods of treating a subject comprising a SCN2A mutation, a mutated SCN2A voltage-gated sodium channel protein, a SLC6A1 mutation, a SCN1A mutation or an IRF2BPL mutation. Methods of treating a subject with elevated levels of basal mitochondrial respiration, mitochondrial ATP-linked respiration, or a combination thereof, are also provided. Methods of treating a subject with a seizure disorder and method of treating a subject with a neurodegenerative or neurological disorder with mitochondrial dysfunction, optionally, with elevated levels of basal and/or ATP-linked respiration, are provided. Methods of improving survival of motor neurons or other neuronal cells types, reducing mitochondrial basal and/or ATP-linked respiration, reducing cellular oxidative stress, or a combination thereof, additionally are provided. In exemplary embodiments, the method comprises administering to the subject copper-ATSM (CuATSM) in an effective amount.

Abstract: The present disclosure relates to methods of targeting specific cell types within the retina using optimized gene therapy vectors in combination with a glycoside hydrolase enzyme, such as neuraminidase. In particular, the disclosure provides gene therapy vectors administered with a glycoside hydrolase enzyme to specifically target retinal cells and methods of treating visual impairment, retinal degeneration and vision-related disorders.

Abstract: The present disclosure relates to methods of targeting specific cell types within the retina using optimized gene therapy vectors. In particular, the disclosure provides gene therapy vectors to specifically target retinal cells and methods of treating visual impairment, retinal degeneration and vision-related disorders such as CLN disease.

Abstract: Disclosed is a method of resistance welding between composite articles. A conductive element is provided between faying surfaces, having a plurality of lower resistivity electrode portions spaced apart along the length of the contact area between the composite articles. The electrode portions can be used to spot weld across the electrode portions, and along a longitudinal portion of the conductive element between the electrode portions by application of an electrical current. Also disclosed are apparatus for use in the resistance welding methods and composite articles and structures and elements incorporating the conductive element.

Abstract: Disclosed are methods for genetically engineering cells using Adeno-associated viral (AAV) delivery of a CRISPR/CAS9 system and ribonucleoproteins for integration.

Abstract: A method of determining a patient's compliance with a prescription, the prescription indicating the dosage of prescription pills to be consumed in a certain period, the method comprising: (a) receiving an image of one or more remaining pills from a patient on a given date, the given date being after an initial date when the patient received an initial number of the prescription pills; (b) confirming that the remaining pills are the same type as the prescription pills; (c) determining whether the number of the remaining pills corresponds with an expected number of remaining pills, the expected number of remaining pills being the initial number minus a calculated number of pills taken between the initial date and the given date based on the dosage; and (d) generating a report of the patient's compliance based on whether the number of the remaining pills corresponds to the expected number of remaining pills as determined in step (c).

Abstract: A device for alleviating the complaints of a trapeziometacarpal joint disease from the degenerative, inflammatory, and rheumatic spectrum. The load on the trapeziometacarpal joint changed by arthrosis can be dynamically relived by means of said device. The device includes a splint, which is detachably fastened to the wrist on one side and reaches under the first thumb joint of the diseased hand on the other side. The splint accommodates the thumb in a natural resting position of thumb. If the thumb is bent, then, below the thumb joint, the thumb stresses the splint against the retainer fastened to the wrist as a result of the radial motion or bending of the thumb and thereby lifts the trapeziometacarpal joint minimally from a usual seat thereof. A gap thus arises between the joint bodies that engage with each other. The joint surfaces no longer painfully rub against each other.

Abstract: A method for producing a solar cell that has a semiconductor substrate of a first conductivity type. The method includes producing a plurality of passage openings, creating a layer of a conductivity type opposite the first conductivity type along a front side, producing a front-side contact in the form of a metallization and a back-side contact. Electrically conductive front-side contact areas bound the passage openings on the front side and are formed when the front-side contact is formed. The passage openings are provided with an electrically insulating first layer on the inside, and an electrically conductive material is subsequently introduced, starting from a back side, through the passage openings up to the front-side contact areas while back-side contact areas are simultaneously formed.

Abstract: A method for producing an MWT-PERC solar cell is provided, in which openings in the substrate of the solar cell have contact passages and emitter regions that are present on the back side of the solar cell are completely removed outside the contact passages and a dielectric layer is applied on the back side, whereby a paste, which does not act in an electrically contacting manner opposite the substrate, is used for the contact passages.

Abstract: A radiolucent surgical instrument comprising an internal stiffener composed of a first composite material having a first modulus and an overmold component formed around at least a portion of the internal stiffener and composed of a second composite material having a second modulus. The first modulus may be greater than the second modulus. The overmold component may be formed around the internal stiffener via injection molding. The internal stiffener may be a structural laminate fabricated by composite ply lay-up and cure and may have a bending stiffness between approximately 10 MSI and 16 MSI. The overmold component may be a short fiber reinforced thermoplastic form and may have a non-uniform distribution of thickness. The surgical instrument may include, for example, retractors, forceps, elevators, dissectors, suction tubes, drill guides, or separators.