Abstract: The present disclosure relates to a system in package having a chiplet with a first substrate and a first die deposed over the first substrate, a second die, a second substrate that the chiplet and the second die are deposed over, and a heatsink spreader deposed over the chiplet and the second die. Herein, the first substrate includes layered-cake shaped heatsink stanchions that are coupled to the first die, and the second substrate includes layered-cake shaped heatsink stanchions that are coupled to the chiplet and the second die. As such, heat generated by the first die can be dissipated by the heatsink stanchions within the first and second substrates, and heat generated by the second die can be dissipated by the heatsink stanchions within the second substrate. Furthermore, the heat generated by the first die and the second die can be dissipated by the heatsink spreader above them.

Abstract: Reagents and methods for extracting and stabilizing metabolites at room temperature and methods in which metabolites and one or more of proteins, lipids and nucleic acids are extracted from a single sample in a unified workflow.

Abstract: Disclosed are technologies for previewing a webpage. A first request comprising a first content layout for the webpage and indicia of one or more first device characteristics corresponding to emulation in a webpage preview may be received. A plurality of first style rules may be generated that may include an indication that at least one of the one or more content items is hidden based on the received indicia of one or more first device characteristics. A user designation regarding a preview status of the at least one hidden content item may be received. A preview of the webpage based on the plurality of first style rules may be rendered. The preview may identify the at least one hidden content item in the preview of the webpage if the preview status is positive, or exclude that content item in the preview if the preview status is negative.

Abstract: Antibody molecules that bind to CD73 are disclosed. The anti-CD73 antibody molecules can be used to treat, prevent and/or diagnose cancer.

Abstract: The present disclosure relates to anti-IL-27 antibodies, and antigen-binding portions thereof. The disclosure also relates to methods for treating or ameliorating one or more symptoms of a disease, such as cancer, by administering the antibodies or antigen-binding portion thereof. The disclosure also relates to methods for detecting IL-27 in, for example, a subject or a sample.

Abstract: The present disclosure relates to anti-IL-27 antibodies, and antigen-binding portions thereof. The disclosure also relates to methods for treating or ameliorating one or more symptoms of a disease, such as cancer, by administering the antibodies or antigen-binding portion thereof. The disclosure also relates to methods for detecting IL-27 in, for example, a subject or a sample.

Abstract: The present disclosure relates to anti-IL-27 antibodies, and antigen-binding portions thereof. The disclosure also relates to methods for treating or ameliorating one or more symptoms of a disease, such as cancer, by administering the antibodies or antigen-binding portion thereof. The disclosure also relates to methods for detecting IL-27 in, for example, a subject or a sample.

Abstract: Antibody molecules that bind to CD73 are disclosed. The anti-CD73 antibody molecules can be used to treat, prevent and/or diagnose cancer.

Abstract: A method of creating and previewing a webpage may be provided. The method may include receiving a first request having a first content layout for the web page and indicia of one or more first device characteristics that describe at least one of hardware, software, or network configuration of a first device to be emulated in previewing the webpage; generating a plurality of first style rules, including an indication that at least one of the one or more content items is hidden; rendering a preview of the webpage based on the first style rules, the preview identifying each of the at least one of the one or more content items that is hidden in the preview of the webpage; creating a first configuration breakpoint corresponding to the first style rules; and saving the first configuration breakpoint and the first style rules in a style sheet corresponding to the webpage.

Abstract: Antibody molecules that bind to CD73 are disclosed. The anti-CD73 antibody molecules can be used to treat, prevent and/or diagnose cancer.

Abstract: Reagents and methods for extracting and stabilizing metabolites at room temperature and methods in which metabolites and one or more of proteins, lipids and nucleic acids are extracted from a single sample in a unified workflow.

Abstract: A method of creating an adaptive webpage using a computer operating as an adaptive webpage editor includes receiving a first request comprising a first content layout for the adaptive web page and one or more first device characteristics. A plurality of first style rules are generated based on the first content layout and the first device characteristics and a first configuration breakpoint corresponding to the first style rules is created. The first style rules are saved in a style sheet corresponding to the adaptive webpage.

Abstract: The present disclosure relates to anti-IL-27 antibodies, and antigen-binding portions thereof. The disclosure also relates to methods for treating or ameliorating one or more symptoms of a disease, such as cancer, by administering the antibodies or antigen-binding portion thereof. The disclosure also relates to methods for detecting IL-27 in, for example, a subject or a sample.

Abstract: An apparatus and method is described for providing training and visual feedback of a preferred swing. The apparatus includes bands that are secured to the arms or legs of a user and an alignment member that is attached to the bands. In use, the ends of the alignment member are visible to the user throughout an entire swing of a sport equipment without requiring head movement of the user. By observing the position of the ends of the alignment member relative to the body of the user, the user or trainer is able to determine whether a preferred swing is being executed by the user.

Abstract: The present invention provides, inter alia, apparatuses and methods for ionizing samples that are in gaseous phase or can be vaporized/sublimated. The samples include samples to be analyzed and mass calibrants that serve as standards. In addition, the present invention also provides calibrant formulations that release mass calibrants in a slow, controlled manner.

Abstract: Compositions and methods are provided for the use of SOS pathway targeted agents in antimicrobial formulations. The innate sensitivity of bacteria to antibiotics is increased by disrupting a mechanism that normally activates the bacterial SOS response or by inhibiting steps in the SOS response pathway itself. SOS response induction can result from exposure of bacteria to certain antibiotics, including ?-lactam antibiotics and other agents that affect cell wall synthesis. By transiently delaying bacterial cell division, SOS response induction interferes with bacterial killing by ordinarily lethal concentrations of these drugs A pharmaceutical composition comprising an SOS targeted agent is administered to a patient suffering from a microbial infection, in combination with an antibiotic that induces an SOS response.

Abstract: A method of analyzing a sample comprising multiple protein species is provided. The proteins are separated by species such that the multiple protein species emerge in a sequential order and are then digested in the sequential order in which they emerge from the separation process. The digested proteins are introduced into a mass spectrometer in the same sequential order so that, within a given time window, the digested proteins introduced into the mass spectrometer are covariant.

Abstract: A method for diagnosing a body weight condition or predisposition to a body weight condition in an animal by determining observed level(s) of at least one biomarker in a tissue or biofluid sample from the animal and comparing the observed level(s) to reference level(s) for the biomarker; wherein the observed level(s) relative to the reference level(s) are individually or collectively indicative of the body weight condition or predisposition.

Abstract: An apparatus for ionizing an analyte sample with a mass calibrant is provided. The apparatus includes an ionization chamber defining an ionization region, a first passageway coupled to the ionization region for delivering the analyte sample to the ionization region, a second passageway leading to a mass analyzer having an orifice arranged adjacent to the ionization region to receive ions from the ionization region, a third passageway coupled to the ionization chamber at a first end and having a second end with an orifice arranged to receive gaseous neutral mass calibrant molecules, and an ionization device arranged within the ionization chamber. The ionization device generates primary ions from the analyte sample, and the primary ions ionize a portion of the gaseous neutral mass calibrant molecules received into the ionization region via the third passageway.

Abstract: The present invention provides, inter alia, apparatuses and methods for ionizing samples that are in gaseous phase or can be vaporized/sublimated. The samples include samples to be analyzed and mass calibrants that serve as standards. In addition, the present invention also provides calibrant formulations that release mass calibrants in a slow, controlled manner.