Abstract: The dispensing of sample liquids is performed, particularly in case of high-throughput screening, by means of automatic dosing devices. Between individual dosing processes, the standstill of the dosing device may lead to an outgassing of the sample liquid existing in the dosing device, and to crystallization. In order to improve the operational safety, it is provided according to the method of the invention that a stand-by routine is initiated after termination of a dosing process. In the stand-by routine, liquid is dispensed via a dosing orifice of the dosing device. The dispensing step is repeated after a predetermined period of time.