Abstract: The present invention relates to compositions, methods and kits for the treatment of respiratory disease. In particular, the compositions, methods and kits are particularly useful, but not limited to, the treatment or prevention of exacerbations of asthma and chronic obstructive pulmonary disease. The present invention provides a method of treating or preventing a respiratory disease in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of an inhibitor of casein kinase 1, thereby treating or preventing a respiratory disease in a subject. The present invention also provides a method of treating or preventing a respiratory disease in a subject in need thereof, the method comprising administering to the subject a therapeutically effective amount of an inhibitor of ALK5, thereby treating or preventing a respiratory disease in a subject, wherein the inhibitor is administered directly to the airway and/or lungs.

Abstract: A system, device and method for nail care is provided. The nail care system includes a shaping system, a polish removal system and/or a cuticle management system; a vision system; a nail polish application system; and a mobility system. The nail system may further include an accelerated drying system, a hand massage system, a nail identification/diagnosis/estimation of conditions system, an enclosure, a hand/foot rest system, a computer software system, a computer hardware system, a cartridge/pod system, and a multi-tool system. Related apparatuses, techniques and articles are also described.

Abstract: A system and method for resecting a valve in a patient, in which the system includes: a proximal frame and a distal frame opposite the proximal frame, each frame including a plurality of interconnectable frame segments, in which the proximal and distal frames are separated by an adjustable distance and positionable on opposite sides of the valve; an electrode, adjacent to the valve on at least one of the proximal and distal frames, that electrosurgically resects valve tissue; a proximal chamber and a distal chamber coupled to the proximal and distal frames, respectively, that allow passage of fluid and captures at least a portion of resected valve tissue, in which each chamber selectively operates in one of a radially collapsed mode and a radially expanded mode; and a drive system that adjusts the distance between the proximal and distal frames.

Abstract: A system and method for resecting a valve in a patient, in which the system includes: a proximal frame and a distal frame opposite the proximal frame, each frame including a plurality of interconnectable frame segments, in which the proximal and distal frames are separated by an adjustable distance and positionable on opposite sides of the valve; an electrode, adjacent to the valve on at least one of the proximal and distal frames, that electrosurgically resects valve tissue; a proximal chamber and a distal chamber coupled to the proximal and distal frames, respectively, that allow passage of fluid and captures at least a portion of resected valve tissue, in which each chamber selectively operates in one of a radially collapsed mode and a radially expanded mode; and a drive system that adjusts the distance between the proximal and distal frames.

Abstract: A system and method for resecting a valve in a patient, in which the system includes: a proximal frame and a distal frame opposite the proximal frame, each frame including a plurality of interconnectable frame segments, in which the proximal and distal frames are separated by an adjustable distance and positionable on opposite sides of the valve; an electrode, adjacent to the valve on at least one of the proximal and distal frames, that electrosurgically resects valve tissue; a proximal chamber and a distal chamber coupled to the proximal and distal frames, respectively, that allow passage of fluid and captures at least a portion of resected valve tissue, in which each chamber selectively operates in one of a radially collapsed mode and a radially expanded mode; and a drive system that adjusts the distance between the proximal and distal frames.