Abstract: Methods and compositions for treating cancer are disclosed herein. The methods may comprise use of therapeutically effective amounts of one or more therapeutic agents to cause a difference in expression or activity of protein kinase, membrane associated tyrosine/threonine 1 (PKMYT1) in cancer cells that are deficient in protein phosphatase 2 regulatory subunit B alpha (PPP2R2A).

Abstract: The present disclosure provides methods for treating cancer comprising administering one or more therapeutic agents for manipulation of a target gene (e.g., protein kinase, membrane associated tyrosine/threonine 1 (PKMYT1)), wherein the cancer has a mutation in, an altered (e.g., increased or decreased) expression level and/or an altered activity of a biomarker. Provided herein are methods for identifying biomarkers of the disclosure that form a synthetic lethal pair with a target gene (e.g., PKMYT1).

Abstract: The present disclosure provides methods for treating cancer comprising administering one or more therapeutic agents for manipulation of a target gene (e.g., protein kinase, membrane associated tyrosine/threonine 1 (PKMYT1)), wherein the cancer has an altered (e.g., increased or decreased) expression level and/or activity of a biomarker. Provided herein are methods for identifying biomarkers of the disclosure that form a synthetic lethal pair with a target gene (e.g., PKMYT1).

Abstract: The present disclosure provides lethal gene pair targets for cancer treatment, along with methods and compositions for regulating their expression and activity. Gene pairs disclosed herein include tyrosine kinase genes (e.g., SRC, RON, and YES). Also provided are methods and compositions for regulating tyrosine kinase activity, including RON specific pyrazole benzamide inhibitors and methods for gene regulation.

Abstract: System including one or more programs with instructions for storing a plurality of planned departures associated with departure routes and departure fixes in the memory, storing at least one constraint associated with one or more of the departure routes and departure fixes in the memory, generating a departure model for modifying the plurality of planned departures based on the at least one constraint, wherein the departure model comprises a directed graph representing the planned departures, the departure routes, and the departure fixes, determining an optimized set of flows through the departure model based on the at least one constraint, and identifying a reroute for at least one planned departure based on the optimized set of flows.

Abstract: The invention provides peptides that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water-soluble oligomer.

Abstract: Provided herein are methods directed to the prediction and early assessment of the efficacy of cancer treatment regimens, in particular in patients undergoing therapy with a DNA-damaging chemotherapeutic agent, by determining expression levels of certain proteins found to be useful as biomarkers in circulating tumor cells obtained from the patient both prior to and post-treatment.

Abstract: Provided herein are methods directed to the prediction and early assessment of the efficacy of cancer treatment regimens, in particular in patients undergoing therapy with a DNA-damaging chemotherapeutic agent, by determining expression levels of certain proteins found to be useful as biomarkers in circulating tumor cells obtained from the patient both prior to and post-treatment.

Abstract: System including one or more programs with instructions for storing a plurality of planned departures associated with departure routes and departure fixes in the memory, storing at least one constraint associated with one or more of the departure routes and departure fixes in the memory, generating a departure model for modifying the plurality of planned departures based on the at least one constraint, wherein the departure model comprises a directed graph representing the planned departures, the departure routes, and the departure fixes, determining an optimized set of flows through the departure model based on the at least one constraint, and identifying a reroute for at least one planned departure based on the optimized set of flows.

Abstract: The invention provides peptides that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water-soluble oligomer.

Abstract: The general purpose of the new bicycle skirt clip is to provide a bicycle rider wearing a dress or skirt the security of having his or her dress or skirt remain in a natural and modest position while riding. The current invention secures the hem of a dress or skirt as to keep the skirt from being blown up or shifted from its desired position.

Abstract: The invention provides peptides that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water-soluble oligomer.

Abstract: Provided herein are methods directed to the prediction and early assessment of the efficacy of cancer treatment regimens, in particular in patients undergoing therapy with a DNA-damaging chemotherapeutic agent, by determining expression levels of certain proteins found to be useful as biomarkers in circulating tumor cells obtained from the patient both prior to and post-treatment.

Abstract: The invention provides peptides that are chemically modified by covalent attachment of a water soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water-soluble oligomer.

Abstract: The invention provides peptides that are chemically modified by covalent attachment of a water-soluble oligomer. A conjugate of the invention, when administered by any of a number of administration routes, exhibits characteristics that are different from the characteristics of the peptide not attached to the water-soluble oligomer.

Abstract: A speaker and antenna configuration for use in a mobile device. The speaker and antenna configuration includes a speaker, an antenna, and a circuit board. The circuit board includes at least one sound passageway. The speaker is mounted on one side of the circuit board such that sound from the speaker passes substantially through the sound passageway. The antenna is situated on the other side of the circuit board. In one embodiment, the antenna includes a perforation configured such that sound from the speaker passes substantially through the perforation.

Abstract: A speaker and antenna configuration for use in a mobile device. The speaker and antenna configuration includes a speaker, an antenna, and a circuit board. The circuit board includes at least one sound passageway. The speaker is mounted on one side of the circuit board such that sound from the speaker passes substantially through the sound passageway. The antenna is situated on the other side of the circuit board. In one embodiment, the antenna includes a perforation configured such that sound from the speaker passes substantially through the perforation.