Abstract: The present invention relates to compounds of formula I: in which p, q, Y1, Y2, R1, R2a, R2b, R3a, R3b, R4a, R4b, R5a, R5b, R7 and R8 are defined in the Summary of the Invention; capable of inhibiting the activity of SHP2. The invention further provides a process for the preparation of compounds of the invention, pharmaceutical preparations comprising such compounds and methods of using such compounds and compositions in the management of diseases or disorders associated with the aberrant activity of SHP2.

Abstract: Systems and methods for joint document signing are described. According to one aspect, a method for joint document signing includes establishing a live communication session including a plurality of users. In some cases, the plurality of users correspond to a set of signers of a document. The method further includes initiating a signing process during the live communication session, receiving a signature for the document from each of the plurality of users during the live communication session based on the signing process, and generating a signed document including the signature from each of the plurality of users.

Abstract: Disclosed herein is a light transmissive fiber integrated knit textile for use on consumer electronic products. The knit textile is depicted to be constructed with light transmissive fibers integration through a weave-in/inlay knit technique with a flat-bed knitting construction. The light transmissive knitted textile is also tethered to a portable electronic device, allowing for the light transmitting fibers knitted into the fabric to define a lighting display on said fabric.

Abstract: In one aspect, a method for assembling a tower section of a lattice tower structure for a wind turbine on a tower assembly fixture may generally include installing a first trolley onto a first fixture arm of the fixture and installing a second trolley onto a second fixture arm of the fixture. In addition, the method may include securing a first support leg of the tower section to the first trolley, securing a second support leg of the tower section to the second trolley and coupling at least one secondary support member between the first and seconds support legs.

Abstract: A system for assembling a tower section of a lattice tower structure for a wind turbine may generally include a tower assembly fixture having a plurality of radially extending fixture arms, wherein each fixture arm extends between a first end and a second end. In addition, the system may include a plurality of trolleys. Each trolley may include a base frame configured to be coupled to one of the fixture arms between its first and second ends and a leg mount pivotally coupled to the base frame. The leg mount may be configured to be coupled to a bottom end of a support leg of the tower section such that, when each of the support legs is coupled to its respective leg mount, the support legs are supported above the tower assembly fixture at a substantially vertical orientation.

Abstract: In one aspect, a method for assembling a tower section of a lattice tower structure for a wind turbine on a tower assembly fixture may generally include installing a first trolley onto a first fixture arm of the fixture and installing a second trolley onto a second fixture arm of the fixture. In addition, the method may include securing a first support leg of the tower section to the first trolley, securing a second support leg of the tower section to the second trolley and coupling at least one secondary support member between the first and seconds support legs.

Abstract: A system for assembling a tower section of a lattice tower structure for a wind turbine may generally include a tower assembly fixture having a plurality of radially extending fixture arms, wherein each fixture arm extends between a first end and a second end. In addition, the system may include a plurality of trolleys. Each trolley may include a base frame configured to be coupled to one of the fixture arms between its first and second ends and a leg mount pivotally coupled to the base frame. The leg mount may be configured to be coupled to a bottom end of a support leg of the tower section such that, when each of the support legs is coupled to its respective leg mount, the support legs are supported above the tower assembly fixture at a substantially vertical orientation.

Abstract: The present invention relates to a cosmetic and/or pharmaceutical active component for stimulating proteasome activity of skin cells comprising the broth obtained by inoculating a biomass of the algae, Gracilaria spp., particularly the algae, Gracilaria tikvahiae, with a yeast culture, and allowing fermentation of the biomass to produce a fermentation broth. Also described is a cosmetic and/or pharmaceutical active component for stimulating proteasome activity of skin cells comprising an extract of the algae, Gracilaria tikvahiae. The present invention also relates to topical compositions comprising as a cosmetic and/or pharmaceutical active component a ferment of the algae, Gracilaria spp., particularly the algae, Gracilaria tikvahiae, or an extract of the algae, Gracilaria tikvahiae, or a combination of both.

Abstract: A hair conditioning sunscreen device for applying sunscreen and hair conditioner to a scalp covered by fine hair to provide protection to the scalp and inhibit damage to the hair includes a mixture of a sunscreen and a hair conditioner wherein the mixture is applicable to skin covered by fine hair such that the skin is protected from ultraviolet light and the hair is conditioned by the hair conditioner.

Abstract: A method is described for the reproducible quantification of biomarker expression, including biomarker expression in a tissue sample. Methods and systems are described whereby reproducible scores for biomarker expression are obtained independent of instrument, its location, or operator.

Abstract: According to some embodiments, information about an insurance claim associated with a base insurance policy and a weather event may be received. Based on the received information, it may be determined if the insurance claim is associated with an amount of loss that exceeds limits of the base insurance policy and stretch endorsement. It may also be determined if the insurance claim is associated with a type of loss covered by an extreme weather endorsement of the base insurance policy and associated stretch endorsement. Further, it may be determined if the extreme weather endorsement is associated with the insurance policy and if the weather event satisfies an extreme weather trigger condition. If the limits are exceeded, the type of loss is covered, the extreme weather endorsement is associated with the insurance policy, and the weather event satisfies the extreme weather trigger condition, payment in connection with the insurance claim may be facilitated.

Abstract: A method of localizing reproduction assisting hyaluronic acid to reproductive cell surfaces by covalently linking it to lipids is disclosed.

Abstract: A method of localizing reproduction assisting hyaluronic acid to reproductive cell surfaces by covalently linking it to lipids is disclosed.

Abstract: A method and system for automatically evaluating quality of a slide-mounted tissue sample includes receiving a digital image of a magnified portion of the slide-mounted tissue sample. At least one quantitative quality indicator is automatically determined for at least one of the samples, and the digital image of the magnified portion of the sample. Each of the quantitative quality indicators is automatically compared to a respective minimum acceptable quality threshold. The quantitative quality indicators and associated quality thresholds are selected for suitability with an automated quantitative immunoassay. Failure of one or more of the quantitative quality indicators to meet its respective minimum acceptable quality threshold suggests that the sample is unsuitable for subsequent automated pathological evaluation.

Abstract: The present invention relates to a cosmetic and/or pharmaceutical active component for stimulating proteasome activity of skin cells comprising the broth obtained by inoculating a biomass of the algae, Gracilaria spp., particularly the algae, Gracilaria tikvahiae, with a yeast culture, and allowing fermentation of the biomass to produce a fermentation broth. Also described is a cosmetic and/or pharmaceutical active component for stimulating proteasome activity of skin cells comprising an extract of the algae, Gracilaria tikvahiae. The present invention also relates to topical compositions comprising as a a cosmetic and/or pharmaceutical active component a ferment of the algae, Gracilaria spp., particularly the algae, Gracilaria tikvahiae, or an extract of the algae, Gracilaria tikvahiae, or a combination of both.

Abstract: A method of localising reproduction assisting hyaluronic acid to reproductive cell surfaces by covalently linking it to lipids is disclosed.

Abstract: A method and system for automatically evaluating quality of a slide-mounted tissue sample includes receiving a digital image of a magnified portion of the slide-mounted tissue sample. At least one quantitative quality indicator is automatically determined for at least one of the samples, and the digital image of the magnified portion of the sample. Each of the quantitative quality indicators is automatically compared to a respective minimum acceptable quality threshold. The quantitative quality indicators and associated quality thresholds are selected for suitability with an automated quantitative immunoassay. Failure of one or more of the quantitative quality indicators to meet its respective minimum acceptable quality threshold suggests that the sample is unsuitable for subsequent automated pathological evaluation.

Abstract: Method of localizing hyaluronic acid to the surface of a cell or multi-cellular structure by contacting the cell or multi-cellular structure with a dispersion of a construct of the structure F—S1—S2-L where F—S1 is a polymer or oligomer of hyaluronic acid including a terminal glycamine residue (S1), S2 is —CO(CH2)4CO—, —CO(CH2)5CO— or —CO(CH2)6CO—, and L is a phosphatidylethanolamine.

Abstract: A method and system for automatically evaluating quality of a slide-mounted tissue sample includes receiving a digital image of a magnified portion of the slide-mounted tissue sample. At least one quantitative quality indicator is automatically determined for at least one of the samples, and the digital image of the magnified portion of the sample. Each of the quantitative quality indicators is automatically compared to a respective minimum acceptable quality threshold. The quantitative quality indicators and associated quality thresholds are selected for suitability with an automated quantitative immunoassay. Failure of one or more of the quantitative quality indicators to meet its respective minimum acceptable quality threshold suggests that the sample is unsuitable for subsequent automated pathological evaluation.