Patents by Inventor Christine Wooddell

Christine Wooddell has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR THE TREATMENT OF ALPHA-1 ANTITRYPSIN DEFICIENCY (AATD)
    Publication number: 20220305046
    Abstract: Described are methods for treating alpha-1 antitrypsin deficiency (AATD) in a human patient in need of treatment, using pharmaceutical compositions that include AAT RNAi agents. The pharmaceutical compositions disclosed herein that include AAT RNAi agents, when administered to a human patient in need thereof, treat liver diseases associated with AAT deficiency such as chronic hepatitis, cirrhosis, increased risk of hepatocellular carcinoma, transaminitis, cholestasis, fibrosis, fulminant hepatic failure, and other liver-related diseases.
    Type: Application
    Filed: June 5, 2020
    Publication date: September 29, 2022
    Applicant: Arrowhead Pharmaceuticals, Inc.
    Inventors: Bruce Given, Dawn Christianson, James C. Hamilton, Zhen Li, Rui Zhu, Christine Wooddell, Tao Pei
  • RNAi agents for Hepatitis B virus infection
    Patent number: 10780108
    Abstract: Described are compositions and methods for inhibition of Hepatitis B virus gene expression. RNA interference (RNAi) agents for inhibiting the expression of Hepatitis B virus gene are described. The HBV RNAi agents disclosed herein may be targeted to cells, such as hepatocytes, for example, by using conjugated targeting ligands. Pharmaceutical compositions comprising one or more HBV RNAi agents optionally with one or more additional therapeutics are also described. Delivery of the described HBV RNAi agents to infected liver in vivo provides for inhibition of HBV gene expression and treatment of diseases and conditions associated with HBV infection.
    Type: Grant
    Filed: August 4, 2017
    Date of Patent: September 22, 2020
    Assignee: ARROWHEAD PHARMACEUTICALS, INC.
    Inventors: Zhen Li, Rui Zhu, Christine Wooddell, Bruce D. Given, Tao Pei, David L. Lewis, Lauren J. Almeida, David B. Rozema, Darren H. Wakefield
  • RNAi Agents for Hepatitis B Virus Infection
    Publication number: 20190292547
    Abstract: Described are compositions and methods for inhibition of Hepatitis B virus gene expression. RNA interference (RNAi) agents for inhibiting the expression of Hepatitis B virus gene are described. The HBV RNAi agents disclosed herein may be targeted to cells, such as hepatocytes, for example, by using conjugated targeting ligands. Pharmaceutical compositions comprising one or more HBV RNAi agents optionally with one or more additional therapeutics are also described. Delivery of the described HBV RNAi agents to infected liver in vivo provides for inhibition of HBV gene expression and treatment of diseases and conditions associated with HBV infection.
    Type: Application
    Filed: August 4, 2017
    Publication date: September 26, 2019
    Inventors: Zhen Li, Rui Zhu, Christine Wooddell, Bruce D. Given, Tao Pei, David L. Lewis, Lauren J. Almeida, David B. Rozema, Darren H. Wakefield
  • Enhancing intermolecular integration of nucleic acids using integrator complexes
    Patent number: 7262056
    Abstract: We disclose compositions and processes for enhancing transposon mediated integration of a nucleic acid molecule into another target nucleic acid molecule. Integration by an integrator complex is enhanced by cationic reagents.
    Type: Grant
    Filed: November 8, 2002
    Date of Patent: August 28, 2007
    Assignee: Mirus Bio Corporation
    Inventors: Christine Wooddell, Hans Herweijer, Jon A. Wolff
  • DNA cassette for cellular expression of small RNA
    Publication number: 20050196862
    Abstract: We describe expression cassettes and processes for preparing expression cassettes that can be delivered to animal cells in vivo or in vitro. Delivery of the cassettes results in expression of small RNA transcripts such as siRNA in the cell. The cassettes can by used to inhibit gene expression in the cell and to screen siRNA and other RNA sequences for functional efficacy.
    Type: Application
    Filed: August 29, 2003
    Publication date: September 8, 2005
    Inventors: Christine Wooddell, Hans Herweijer, Jon Wolff
  • Enhancing intermolecular integration of nucleic acids using integrator complexes
    Publication number: 20040126887
    Abstract: We disclose compositions and processes for enhancing transposon mediated integration of a nucleic acid molecule into another target nucleic acid molecule. Integration by an integrator complex is enhanced by cationic reagents.
    Type: Application
    Filed: November 8, 2002
    Publication date: July 1, 2004
    Inventors: Christine Wooddell, Hans Herweijer, Jon A. Wolff
  • Processes for transposase mediated integration into mammalian cells
    Publication number: 20030143740
    Abstract: We disclose compositions and processes for transferring a nucleic acid into a mammalian cell utilizing a transposase to achieve nonviral integration of exogenous nucleic acid into the chromosomal DNA of the cell.
    Type: Application
    Filed: October 15, 2002
    Publication date: July 31, 2003
    Inventors: Christine Wooddell, Hans Herweijer, Jon A. Wolff