Abstract: The invention relates to solid lipid nanoparticle for intracellular release of active substances, can be used in the pharmaceutical industry, in the medicine, cosmetics, as well as for food supplements. Solid lipid nanoparticle has spherical shape with a diameter of 15 - 100 nm, the lipid is a solid lipid selected from natural plant wax or its synthetic analogue, as the surface acting agent is used TMDSC. The particles of solid lipid nanoparticle is characterized with high melting point, high lipophilicity and low (or lack) of in-vitro dissolution profile. The system is lipase-resistant and is capable to freely penetrate through cell membranes into cells where to release the active substance(s) due to an intracellular digestion with controllable depo-effect. In a second aspect, the invention relates to a method of production of the solid lipid nanoparticle. The preferred technology for production of the compositions is a Phase Inversion Temperature method.

Abstract: The invention relates to mucoadhesive dispersion nanoparticle system applicable in pharmacy, medicine and cosmetics, especially by administration to surfaces with intensive physiological clearance such as nasal, pulmonal, ocular, oral, throat, rectal, vaginal etc. surfaces, as well as to the method for production such mucoadhesive dispersion nanoparticle system. The composition of mucoadhesive dispersion nanoparticle system comprising in an aqueous medium 0.01 to 2.00 w % hydroxypropyl methyl cellulose and from 0.10 to 10 w % dispersed solid lipid nanoparticles (SLN) for intracellular release of active substances. The advantages of the composition of SLN mucoadhesive dispersion nanoparticle system of the invention are an increased efficacy and controllable depo-effect for transport and delivery of active substances, forming of a continuous film over the applied epithelial surface and substantially increasing of the retention time of the applied dose.

Abstract: The invention relates to solid lipid nanoparticle for intracellular release of active substances, can be used in the pharmaceutical industry, in the medicine, cosmetics, as well as for food supplements. Solid lipid nanoparticle has spherical shape with a diameter of 15-100 nm, the lipid is a solid lipid selected from natural plant wax or its synthetic analogue, as the surface acting agent is used TMDSC. The particles of solid lipid nanoparticle is characterized with high melting point, high lipophilicity and low (or lack) of in-vitro dissolution profile. The system is lipase-resistant and is capable to freely penetrate through cell membranes into cells where to release the active substance(s) due to an intracellular digestion with controllable depo-effect. In a second aspect, the invention relates to a method of production of the solid lipid nanoparticle. The preferred technology for production of the compositions is a Phase Inversion Temperature method.

Abstract: An aqueous pharmaceutical composition comprising: a) 0.005 to 10% by wt of one or more water-soluble pharmaceutically active ingredients or pharmaceutically acceptable salts thereof; b) from 0.01 to 10% by wt hydroxypropyl methyl cellulose having a viscosity of from 2500 to 5500 cps (mPa·s); and c) a buffer for maintaining the pH of the aqueous pharmaceutical composition from 5 to 7; can be prepared by a method which comprises: i) dissolving the above components in water to form an aqueous solution, and ii) filtering the aqueous solution formed in i) through a sieve having a mesh size from ?1 micron but ?10 microns. The compositions obtainable by this method are capable of demonstrating improved mucoadhesive consistency and stability.