Patents by Inventor Christof Biebricher

Christof Biebricher has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process and agent for instabilizing viral quasi-species-distributions avoiding resistance phenomena
    Patent number: 7015017
    Abstract: A process for instabilizing viral quasi-species-distributions under avoidance of resistance phenomena by replication of the nucleic acids of the viruses present in the quasi-species-distribution by of a defective replication system, a) whereby the defective replication system has a rate of misincorporation for nucleotides above the rate of misincorporation of the viral wild-type-replication system and, whereby the viruses are replicated by the replication system having the higher rate of misincorporation at least as effectively as it is done by the replication system of the wild-type virus, b) and/or negative influence of the replication of the consensus-sequence (nucleic acid sequence of the wild-type virus) in relation to other replicatable nucleic acids.
    Type: Grant
    Filed: October 25, 2001
    Date of Patent: March 21, 2006
    Assignee: Evotec Biosystems AG
    Inventors: Manfred Eigen, Andreas Schwienhorst, Christof Biebricher, Björn Lindemann, Esteban Domingo, John Holland, Karsten Henco
  • Process and agent for instabilizing viral quasi-species-distributions avoiding resistance phenomena
    Publication number: 20020107220
    Abstract: A process for instabilizing viral quasi-species-distributions under avoidance of resistance phenomena by replication of the nucleic acids of the viruses present in the quasi-species-distribution by of a defective replication system,
    Type: Application
    Filed: October 25, 2001
    Publication date: August 8, 2002
    Applicant: EVOTECH BIOSYSTEMS AG
    Inventors: Manfred Eigen, Andreas Schwienhorst, Christof Biebricher, Bjorn Lindemann, Esteban Domingo, John Holland, Karsten Henco
  • Process and agent for instabilizing viral quasi-species-distributions avoiding resistance phenomena
    Patent number: 6423516
    Abstract: A process for instabilizing viral quasi-species-distributions under avoidance of resistance phenomena by replication of the nucleic acids of the viruses present in the quasi-species-distribution by of a defective replication system, a) whereby the defective replication system has a rate of misincorporation for nucleotides above the rate of misincorporation of the viral wild-type-replication system and, whereby the viruses are replicated by the replication system having the higher rate of misincorporation at least as effectively as it is done by the replication system of the wild-type virus, b) and/or negative influence of the replication of the consensus-sequence (nucleic acid sequence of the wild-type virus) in relation to other replicatable nucleic acids.
    Type: Grant
    Filed: March 22, 1996
    Date of Patent: July 23, 2002
    Assignee: Evotec BioSystems AG
    Inventors: Manfred Eigen, Andreas Schwienhorst, Christof Biebricher, Björn Lindemann, Esteban Domingo, John Holland, Karsten Henco
  • Method for the production of a vehicle substance which is capable of covalent bonding with biologically active matter
    Patent number: 4177038
    Abstract: Process for preparing a vehicle substance capable of covalent bonding with iological material, especially enzymes, by reacting a matrix containing --OH or NH.sub.2 groups with an organic diisocyanate under anhydrous conditions. The distance between the matrix and biological material may be extended by a stepwise reaction of the matrix with an organic diisocyanate, and organic spacer containing two or more --OH and/or NH.sub.2 groups and again with an organic diisocyanate. The coupling of the vehicle material with biological material takes place in buffered aqueous solution.
    Type: Grant
    Filed: May 17, 1977
    Date of Patent: December 4, 1979
    Assignee: Max-Planck-Gesellschaft zur Forderung der Wissenschafen e.V.
    Inventors: Christof Biebricher, Rudiger Luce