Patents by Inventor Christof Wehrli

Christof Wehrli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10752569
    Abstract: The present invention relates to an improved process for the manufacture of 2,6-dimethyl-5-hepten-1-al.
    Type: Grant
    Filed: October 12, 2017
    Date of Patent: August 25, 2020
    Assignee: DSM IP ASSETS B.V.
    Inventors: Raphael Beumer, Werner Bonrath, Frank Eisele, Jocelyn Fischesser, Christof Wehrli
  • Publication number: 20190308923
    Abstract: The present invention relates to an improved process for the manufacture of 2,6-dimethyl-5-hepten-1-al.
    Type: Application
    Filed: October 12, 2017
    Publication date: October 10, 2019
    Inventors: Raphael BEUMER, Werner BONRATH, Frank EISELE, Jocelyn FISCHESSER, Christof WEHRLI
  • Patent number: 9561993
    Abstract: The invention relates to a process for the manufacture of substituted dibenzoylmethane derivatives. This economical process provides products in high purity and yields and results in shorter reaction times.
    Type: Grant
    Filed: December 19, 2011
    Date of Patent: February 7, 2017
    Assignee: DSM IP ASSETS B.V.
    Inventor: Christof Wehrli
  • Patent number: 9241938
    Abstract: This invention relates to the use of trigonelline compounds to increase muscle weight during periods of activity or to inhibit muscle loss during periods of inactivity.
    Type: Grant
    Filed: November 20, 2014
    Date of Patent: January 26, 2016
    Assignee: DSM IP ASSETS B.V.
    Inventors: Angelika Friedel, Karin Kuratli, Christof Wehrli, Karin Wertz, Swen Wolfram, Ying Wang-Schmidt
  • Patent number: 9085782
    Abstract: This invention is directed to a process for cleaving glycoside residues from stevioside to produce steviol using a commercially available enzyme mixture containing pectinase, CYTOLASE PCL5®. In preferred methods, the reaction takes place in the presence of a yeast culture. Also described are combinations of Helix pomatia enzymes and CYTOLASE PCL5®.
    Type: Grant
    Filed: January 6, 2011
    Date of Patent: July 21, 2015
    Assignee: DSM IP ASSETS B.V.
    Inventor: Christof Wehrli
  • Publication number: 20150079206
    Abstract: This invention relates to the use of trigonelline compounds to increase muscle weight during periods of activity or to inhibit muscle loss during periods of inactivity.
    Type: Application
    Filed: November 20, 2014
    Publication date: March 19, 2015
    Inventors: Angelika FRIEDEL, Karin KURATLI, Christof WEHRLI, Karin WERTZ, Swen WOLFRAM, Ying WANG-SCHMIDT
  • Patent number: 8772230
    Abstract: This invention relates to the use of niacin and/or trigonelline compounds to increase muscle weight during periods of activity or to inhibit muscle loss during periods of inactivity.
    Type: Grant
    Filed: June 10, 2010
    Date of Patent: July 8, 2014
    Assignee: DSM IP Assets B.V.
    Inventors: Angelika Friedel, Karin Kuratli, Christof Wehrli, Karin Wertz, Swen Wolfram, Ying Wang-Schmidt
  • Patent number: 8748491
    Abstract: The present invention refers to tricyclic diterpenes and their derivatives of the formulae (I) and (II), wherein R1 is hydrogen or C1-6-alkyl; R2 is hydroxy, C3-5-acyloxy, hydroxymethyl, 1,3-dihydroxypropyl or C1-6-alkyl; R3 and R4 independently from each other are hydrogen, hydroxy, hydroxymethyl, C1-5-acyloxy or C1-6-alkoxy; R5 is C1-6-alkyl, hydroxymethyl carboxy or methoxycarbonyl; R9 is hydrogen, hydroxymethyl, methoxy, oxo or C1-5-acyloxy; R10 is hydrogen, or R5 and R9 taken together are —CH2—O— or —O—CH2—; or R5 and R10 taken together are —CO—O—, —O—CO—, —CH2—O— or —O—CH2—; R6 is hydrogen, or R5 and R6 together to form a bond; R7 and R8 independently from each other are C1-6-alkyl, carboxy, x-hydroxy-Cx-alkyl (with x being an integer from 1 to 6), or C1-6-alkoxycarbonyl with the proviso that at least one of R7 and R8 is C1-6-alkyl; R11 and R12 are both hydrogen or R11 and R12 together are oxo, with the further proviso for formula (I) that if R2 is hydroxy R1 is C1-6-alkyl, for use as medicaments for th
    Type: Grant
    Filed: September 3, 2013
    Date of Patent: June 10, 2014
    Assignee: DSM IP Assets B.V.
    Inventors: Antione De Saizieu, Ann Fowler, Regina Goralczyk, Claus Kilpert, Goede Schueler, Christof Wehrli
  • Patent number: 8680147
    Abstract: The present invention relates to novel composition for the treatment, co-treatment or prevention of inflammatory disorders comprising an effective amount of carnosic acid 12-methylether.
    Type: Grant
    Filed: November 21, 2007
    Date of Patent: March 25, 2014
    Assignee: DSM IP Assets B.V.
    Inventors: Daniel Raederstorff, Goede Schueler, Joseph Schwager, Christof Wehrli
  • Publication number: 20140017183
    Abstract: The invention relates to a process for the manufacture of substituted dibenzoylmethane derivatives. This economical process provides products in high purity and yields and results in shorter reaction times.
    Type: Application
    Filed: December 19, 2011
    Publication date: January 16, 2014
    Applicant: DSM IP ASSETS B.V.
    Inventor: Christof Wehrli
  • Publication number: 20140005270
    Abstract: The present invention refers to tricyclic diterpenes and their derivatives of the formulae (I) and (II), wherein R1 is hydrogen or C1-6-alkyl; R2 is hydroxy, C3-5-acyloxy, hydroxymethyl, 1,3-dihydroxypropyl or C1-6-alkyl; R3 and R4 independently from each other are hydrogen, hydroxy, hydroxymethyl, C1-5-acyloxy or C1-6-alkoxy; R5 is C1-6-alkyl, hydroxymethyl carboxy or methoxycarbonyl; R9 is hydrogen, hydroxymethyl, methoxy, oxo or C1-5-acyloxy; R10 is hydrogen, or R5 and R9 taken together are —CH2—O— or —O—CH2—; or R5 and R10 taken together are —CO—O—, —O—CO—, —CH2—O— or —O—CH2—; R6 is hydrogen, or R5 and R6 together to form a bond; R7 and R8 independently from each other are C1-6-alkyl, carboxy, x-hydroxy-Cx-alkyl (with x being an integer from 1 to 6), or C1-6-alkoxycarbonyl with the proviso that at least one of R7 and R8 is C1-6-alkyl; R11 and R12 are both hydrogen or R11 and R12 together are oxo, with the further proviso for formula (I) that if R2 is hydroxy R1 is C1-6-alkyl, for use as medicaments for th
    Type: Application
    Filed: September 3, 2013
    Publication date: January 2, 2014
    Applicant: DSM IP ASSETS B.V.
    Inventors: Antoine DE SAIZIEU, Ann Fowler, Regina Goralczyk, Claus Kilpert, Goede Schueler, Christof Wehrli
  • Patent number: 8552055
    Abstract: The present invention refers to tricyclic diterpenes and their derivatives of the formulae (I) and (II), wherein R1 is hydrogen or C1-6-alkyl; R2 is hydroxy, C3-5-acyloxy, hydroxymethyl, 1,3-dihydroxypropyl or C1-6-alkyl; R3 and R4 independently from each other are hydrogen, hydroxy, hydroxymethyl, C1-5-acyloxy or C1-6-alkoxy; R5 is C1-6-alkyl, hydroxymethyl carboxy or methoxycarbonyl; R9 is hydrogen, hydroxymethyl, methoxy, oxo or C1-5-acyloxy; R10 is hydrogen, or R5 and R9 taken together are —CH2—O— or —O—CH2—; or R5 and R10 taken together are —CO—O—, —O—CO—, —CH2—O— or —O—CH2—; R6 is hydrogen, or R5 and R6 together form a bond; R7 and R8 independently from each other are C1-6-alkyl, carboxy, x-hydroxy-Cx-alkyl (with x being an integer from 1 to 6), or C1-6-alkoxycarbonyl with the proviso that at least one of R7 and R8 is C1-6-alkyl; R11 and R12 are both hydrogen or R11 and R12 together are oxo, with the further proviso for formula (I) that if R2 is hydroxy R1 is C1-6-alkyl, for use as medicaments for the t
    Type: Grant
    Filed: December 23, 2009
    Date of Patent: October 8, 2013
    Assignee: DSM IP Assets B.V.
    Inventors: Antoine De Saizieu, Ann Fowler, Regina Goralczyk, Claus Kilpert, Goede Schueler, Christof Wehrli
  • Patent number: 8491944
    Abstract: A new process for extracting and purifying glucosinolates from plant material, preferably broccoli sprouts or seeds is described. An alcoholic extract is adsorbed onto a basic resin and eluted with ammonia. Optionally, the alcoholic extract is passed through an ion-exchange column containing acidic resin prior to the adsorption/elution step.
    Type: Grant
    Filed: October 4, 2012
    Date of Patent: July 23, 2013
    Assignee: DSM IP Assets B.V.
    Inventors: Christof Wehrli, Jan Schutz
  • Patent number: 8420835
    Abstract: Novel catalytic processes for the production of carnosol from carnosic acid are presented. The carnosic acid may be in pure form, in an impure form, part of a plant extract, or may be present in rosemary needles. The catalyst may be iron, iron salts, a minor amount of water, rosemary needles, or a mixture thereof.
    Type: Grant
    Filed: September 30, 2008
    Date of Patent: April 16, 2013
    Assignee: DSM IP Assets B.V.
    Inventor: Christof Wehrli
  • Publication number: 20130071887
    Abstract: This invention is directed to a process for cleaving glycoside residues from stevioside to produce steviol using a commercially available enzyme mixture containing pectinase, CYTOLASE PCL5®. In preferred methods, the reaction takes place in the presence of a yeast culture. Also described are combinations of Helix pomatia enzymes and CYTOLASE PCL5®.
    Type: Application
    Filed: January 6, 2011
    Publication date: March 21, 2013
    Applicant: DSM IP ASSETS B.V.
    Inventor: Christof Wehrli
  • Publication number: 20130030162
    Abstract: A new process for extracting and purifying glucosinolates from plant material, preferably broccoli sprouts or seeds is described. An alcoholic extract is adsorbed onto a basic resin and eluted with ammonia. Optionally, the alcoholic extract is passed through an ion-exchange column containing acidic resin prior to the adsorption/elution step.
    Type: Application
    Filed: October 4, 2012
    Publication date: January 31, 2013
    Applicant: DSM IP ASSETS B.V.
    Inventors: Christof WEHRLI, Jan SCHUTZ
  • Publication number: 20130018076
    Abstract: This invention relates to the use of trigonelline compounds to increase muscle weight during periods of activity or to inhibit muscle loss during periods of inactivity.
    Type: Application
    Filed: September 7, 2012
    Publication date: January 17, 2013
    Applicant: DSM IP ASSETS B.V.
    Inventors: Angelika FRIEDEL, Karin Kuratli, Christof Wehrli, Karin Wertz, Swen Wolfram, Ying Wang-Schmidt
  • Patent number: 8323707
    Abstract: This invention relates to the use of trigonelline compounds to increase muscle weight during periods of activity or to inhibit muscle loss during periods of inactivity.
    Type: Grant
    Filed: December 3, 2010
    Date of Patent: December 4, 2012
    Assignee: DSM IP Assets B.V.
    Inventors: Angelika Friedel, Karin Kuratli, Christof Wehrli, Karin Wertz, Swen Wolfram, Ying Wang-Schmidt
  • Patent number: 8303998
    Abstract: A new process for extracting and purifying glucosinolates from plant material, preferably broccoli sprouts or seeds is described. An alcoholic extract is adsorbed onto a basic resin and eluted with ammonia. Optionally, the alcoholic extract is passed through an ion-exchange column containing acidic resin prior to the adsorption/elution step.
    Type: Grant
    Filed: August 21, 2009
    Date of Patent: November 6, 2012
    Assignee: DSM IP Assets B.V.
    Inventors: Christof Wehrli, Jan Schütz
  • Patent number: 8299274
    Abstract: Novel catalytic processes for the production of carnosol from carnosic acid using hydrogen peroxide or a peracid are presented. The carnosic acid may be in pure form, in an impure form, part of a plant extract, or may be present in rosemary needles. The catalyst may be iron, iron salts, a minor amount of water, rosemary needles, or a mixture thereof.
    Type: Grant
    Filed: October 21, 2008
    Date of Patent: October 30, 2012
    Assignee: DSM IP Assets B.V.
    Inventor: Christof Wehrli