Abstract: Provided herein are compositions and systems for reconstitution of RNA molecules, including methods for using these molecules. For example, such molecules can be used to deliver a protein coding sequence over two or more viral vectors (such as AAVs), resulting in reconstitution of the full-length protein in a cell. Such methods can be used to deliver a therapeutic protein, for example to treat a genetic disease or cancer.

Abstract: Provided herein are synthetic RNA molecules for reconstitution of RNA molecules, including compositions and methods of using these molecules. For example, such molecules can be used to deliver a protein coding sequence over two or more viral vectors (such as AAVs), resulting in reconstitution of the full-length protein in a cell. Such methods can be used to deliver a therapeutic protein, for example to treat a genetic disease or cancer.

Abstract: Method of operating a valve (1) which connects openings (2, 3) of at least two chambers (4, 5) to one another and, for closing the openings (2, 3) of each of the chambers (4, 5), has at least one dedicated closure member (6, 7), wherein for opening one of the openings (2, 3), the chamber (4, 5) assigned to said opening (2, 3) has generated in it a positive pressure which is higher than a current pressure in the valve-housing interior (8), wherein, by virtue of this positive pressure, the closure member (6, 7) assigned to said opening is raised up from the valve seat (10, 11) assigned to said opening (2, 3) and then, through this opening (2, 3), pressure equalization is carried out between the valve-housing interior (8) and the chamber (4, 5) assigned to said opening (2, 3). (FIG.

Abstract: Method of operating a valve (1) which connects openings (2, 3) of at least two chambers (4, 5) to one another and, for closing the openings (2, 3) of each of the chambers (4, 5), has at least one dedicated closure member (6, 7), wherein for opening one of the openings (2, 3), the chamber (4, 5) assigned to said opening (2, 3) has generated in it a positive pressure which is higher than a current pressure in the valve-housing interior (8), wherein, by virtue of this positive pressure, the closure member (6, 7) assigned to said opening is raised up from the valve seat (10, 11) assigned to said opening (2, 3) and then, through this opening (2, 3), pressure equalization is carried out between the valve-housing interior (8) and the chamber (4, 5) assigned to said opening (2, 3). (FIG.

Abstract: The invention relates to a device that comprises a tool holder that can be adjusted in an x-axis, a y-axis which is perpendicular thereto, and a z-axis that is perpendicular both to the x-axis and the y-axis and that can be pivoted about the z-axis. A dispense head for solid material is mounted on the tool holder as the tool. Two scales are disposed on the dispense head for solid material, said scales weighing the material which is or is to be delivered by the dispense head for solid material. The inventive design with two scales directly mounted on the dispense head for solid material allows for weighing of the material without the dispense head for solid material or the material having to be placed on separate scales.

Abstract: The inventive device comprises a tool holder (1), which can be displaced in an x-direction, in a y-direction that is perpendicular thereto, and in a z-direction that is perpendicular to both the x-direction and the y-direction, and which can rotate about the z-direction. A solid matter dosing head (350), provided as a tool, is automatically attached in a removable manner to the tool holder (1) by means of a permanent magnet (351). The tool can be easily exchanged for another tool due to this automatic removable attachment of said tool to the tool holder (1) involving the use of a permanent magnet (351).

Abstract: The inventive device comprises a tool holder, which can be displaced in an x-direction, in a y-direction that is perpendicular thereto, and in a z-direction that is perpendicular to both the x-direction and the y-direction, and which can rotate about the z-direction A solid matter dosing head, provided as a tool, is automatically attached in a removable manner to the tool holder by means of a permanent magnet. The tool can be easily exchanged for another tool due to this automatic removable attachment of said tool to the tool holder involving the use of a permanent magnet.

Abstract: The inventive device comprises a tool holder (1), which can be displaced in an x-direction, in a y-direction that is perpendicular thereto, and in a z-direction that is perpendicular to both the x-direction and the y-direction, and which can rotate about the z-direction. A solid matter dosing head (350), provided as a tool, is automatically attached in a removable manner to the tool holder (1) by means of a permanent magnet (351). The tool can be easily exchanged for another tool due to this automatic removable attachment of said tool to the tool holder (1) involving the use of a permanent magnet (351).

Abstract: The invention relates to a device that comprises a tool holder that can be adjusted in an x-axis, a y-axis which is perpendicular thereto, and a z-axis that is perpendicular both to the x-axis and the y-axis and that can be pivoted about the z-axis. A dispense head for solid material is mounted on the tool holder as the tool. Two scales are disposed on the dispense head for solid material, said scales weighing the material which is or is to be delivered by the dispense head for solid material. The inventive design with two scales directly mounted on the dispense head for solid material allows for weighing of the material without the dispense head for solid material or the material having to be placed on separate scales.

Abstract: The inventive device comprises a tool holder (1), which can be displaced in an x-direction, in a y-direction that is perpendicular thereto, and in a z-direction that is perpendicular to both the x-direction and the y-direction, and which can rotate about the z-direction. A solid matter dosing head (350), provided as a tool, is automatically attached in a removable manner to the tool holder (1) by means of a permanent magnet (351). The tool can be easily exchanged for another tool due to this automatic removable attachment of said tool to the tool holder (1) involving the use of a permanent magnet (351).