Abstract: The invention relates to a nanostructured delivery system comprising at least one polymer and/or at least one lipid and at least one polymethine dye, for use in treating a subject suffering from an adenocarcinoma comprising adenocarcinoma cells with a gene expression alteration in one or more SLCO genes. Therein, the at least one polymethine dye mediates targeted transport of the nanostructured delivery system into said adenocarcinoma cells. The invention relates further to a pharmaceutical composition comprising the nanostructured delivery system. The invention also relates to a method for targeted transport into neoplastic tissue using the nanostructured delivery system and to a use of the nanostructured delivery system or of the pharmaceutical composition of the invention for detection by fluorescence based on the accumulation of said system or composition in neoplastic tissues or cells.

Abstract: A rotor carrier for a rotor of an electric machine and to a hybrid module with such a rotor carrier. The rotor carrier includes a tubular base body having elements on an outer circumferential surface facing the rotor for connection between base body and rotor, the base body is connected to a hub by a connection element. The connection element has an axial portion which extends along a part of the axial length of the base body and runs coaxial to the latter, in that receptacles for parts of a clutch are provided on an inner circumferential surface of the axial portion remote of the base body, and in that the connection element has a flange area adjoining the axial portion.

Abstract: The present invention relates to an oral thin film comprising a polymer matrix in the form of a solidified foam having voids, wherein the polymer matrix contains at least one active pharmaceutical ingredient, at least one first polymer which comprises a water-soluble polymer and at least one second polymer which comprises a mucoadhesive polymer having a number-average molecular weight of equal to or greater than 100,000 g/mol, a method for producing the oral thin film, and the use of such an oral thin film as a medicament.

Abstract: Submerged nozzle (1) through which molten steel can be poured from a tundish into a mould, said nozzle comprising: a substantially tubular body (2), extending from a first end (3) to a second end (4); a passageway (5), extending through the tubular body (2) along a longitudinal axis (A) from the first end (3) towards the second end (4); at least one inlet port (6), opening into the passageway (5) at said first end (3); a plurality of outlet ports (8), opening into the passageway (5) in a region (7) adjacent to the second end (4); and at least one rotatable insert (10); whereas the submerged nozzle (1) with the at least one rotatable insert (10) is configured that a molten metal entering the submerged nozzle (1) at the at least one inlet port (6) flows through the passageway (5) and around the rotatable insert (10) and exits the submerged entry nozzle (1) via the plurality of outlet ports (8), such that a rotation of the rotatable insert (10) is driven by the stream of molten metal.

Abstract: A method is provided for impedance-controlled fast charging of a stored electrical energy source of a working device, in particular of a stored energy source in a vehicle. In the method: a variable characteristic of an impedance of the stored energy source is detected; a present charging current for charging the stored electrical energy source is set as a function of the variable characteristic of the impedance; the present charging current is temporarily reduced with a steep edge by temporarily connecting a resistive load to the stored energy source and feeding the load using the stored energy source; and a voltage response of the stored energy source to the steep edge is detected as the variable characteristic of the impedance of the stored energy source and is used as the basis for setting the present charging current.

Abstract: The invention relates to a computer-implemented method comprising:—acquiring (406) first training images (108) using a first image acquisition technique (104), each first training image depicting a plant-related motive; —acquiring (402) second training images (106) using a second image acquisition technique (102), each second training image depicting the motive depicted in a respective one of the first training images; —automatically assigning (404) at least one label (150, 152, 154) to each of the acquired second training images; —spatially aligning (408) the first and second training images which are depicting the same one of the motives into an aligned training image pair; —training (410) a machine-learning model (132) as a function of the aligned training image pairs and the labels, wherein during the training the machine-learning model (132) learns to automatically assign one or more labels (250, 252, 254) to any test image (205) acquired with the first image acquisition technique which depicts a plant-r

Abstract: The present invention relates to a power module (1) having reduced intrinsic inductance, comprising an at least partially electrically insulating layer (3) that has a first side (3a) on which a power electronics unit (2) is arranged and a second side (3b) which is opposite the first side (3a), a compensation layer (10) being arranged on the second side (3b), which compensation layer is electrically conductive and to which compensation layer an electric potential can be applied. The invention also relates to a method for producing a power module, preferably a power module as described above.

Abstract: A storage cell for an energy store includes a cell housing in which storage means for storing electric energy are received, at least one connection which is arranged outside of the cell housing and via which the electric energy stored by the storage means can be provided, and at least one electric heating element arranged within the cell housing for heating the storage cell. The cell housing has a connection region, in which the heating element within the cell housing is electrically connected to the cell housing. At least one connection device is provided, having at least one connection element that has a first connection part, which is electrically connected to the cell housing outside of the cell housing and is made of a first material, and a second connection part, which is electrically connected to the first connection part and is made of a second material that differs from the first material.

Abstract: Heat exchanger, in particular for cooling power electronics, comprising an insulating element which separates a first fluid medium, which is in contact with a heat source, from a second fluid medium, which differs in at least one property from the first fluid medium and which is in fluid connection with a heat sink or is itself a heat sink, and a heat transfer element which has a higher thermal conductivity than the insulating element, wherein the insulating element comprises at least a first passage opening in which a first heat transfer element is arranged, wherein the heat transfer element is thermally connected both to the first fluid medium and/or the heat source, and to the second fluid medium and is fluidically sealed with respect to the insulating element by means of a sealing element.

Abstract: A heating device for a prismatic battery cell of a high-voltage battery of a motor vehicle includes two sheet-shaped heating elements to be arranged on two opposite lateral outer sides of a cell housing of the battery cell, and two connecting elements to be arranged on a housing cover of the cell housing. The connecting elements are electrically connected to terminals of the two heating elements. The connecting elements are flexibly formed, at least in certain regions, and as a result the heating elements are connected in a hinge-like manner. The heating device can be arranged by arranging the first heating element on the first lateral outer side of the cell housing, swinging the second heating element over the housing cover, and arranging the second heating element on the second lateral outer side on the cell housing.

Abstract: The invention relates to a trench cutter for producing a cut trench in the soil with a cutter frame, at least one pair of cutting wheels which are supported and driven in a rotatable manner on a lower end of the cutter frame, wherein each cutting wheel has a plurality of cutting teeth along its external circumference, and a discharge means with at least one discharge pump for discharging a cutting fluid from the cut trench in the region of the cutting wheels. According to the invention a switchover means is provided which is designed for switching the discharge means over to a flushing operation, in which a fluid flow generated by at least one discharge pump of the discharge means is generated onto at least one cutting wheel for flushing out the cutting wheel.

Abstract: A power take-off transmission (1), for a motor vehicle, having a power take-off shaft (5), a transmission housing (3), at least two shiftable gears and at least one actuator for engaging the at least two gears. The at least one actuator has an actuating linkage (6) for mechanical actuation from outside the transmission housing (3). The actuating linkage (6) of the power take-off transmission (1) is coupled to an electric motor (8) located outside the transmission housing (3) and by which the at least one actuator can be actuated mechanically. The power take-off transmission can be installed on an agricultural working machine.

Abstract: The invention concerns a batch for the production of a refractory product, a process for the production of a refractory product, a refractory product as well as the use of a refractory product.

Abstract: A method is provided for impedance-controlled fast charging of a stored electrical energy source of a working device, in particular of a stored energy source in a vehicle. In the method: a variable characteristic of an impedance of the stored energy source is detected; a present charging current for charging the stored electrical energy source is set as a function of the variable characteristic of the impedance; the present charging current is temporarily reduced with a steep edge by temporarily connecting a resistive load to the stored energy source and feeding the load using the stored energy source; and a voltage response of the stored energy source to the steep edge is detected as the variable characteristic of the impedance of the stored energy source and is used as the basis for setting the present charging current.

Abstract: A storage cell for an energy store includes a cell housing in which storage means for storing electric energy are received, at least one connection which is arranged outside of the cell housing and via which the electric energy stored by the storage means can be provided, and at least one electric heating element arranged within the cell housing for heating the storage cell. The cell housing has a connection region, in which the heating element within the cell housing is electrically connected to the cell housing. At least one connection device is provided, having at least one connection element that has a first connection part, which is electrically connected to the cell housing outside of the cell housing and is made of a first material, and a second connection part, which is electrically connected to the first connection part and is made of a second material that differs from the first material.

Abstract: A planetary gearset (6) has a sun gear (10) connected rotationally fixedly to an input shaft (8), a carrier (15) that carries planetary gears (11) and is connected rotationally fixedly to an output shaft (16), and a ring gear (14) fixedly connected to a housing (4) that encloses the planetary gearset (6). To reduce the noise emission from the planetary gearset with as little structural complexity as possible without reducing its efficiency due to pressure rings that are guided and slide against the planetary gears and the carrier, the sun gear (10), the planetary gears (11) and the ring gear (14) are provided with helical teeth and the input shaft (8) is at least indirectly supported on the housing (4), in both axial directions, by way of a single roller bearing (20).

Abstract: The invention relates to a method for operating a lithium ion battery (1) comprising at least one lithium ion cell and a heating device (2), wherein: the heating device (2) is designed to operate the lithium ion battery (1) in a temperature range between 5 and 90° C.; the lithium ion cell comprises an anode (4), a cathode (5), a separator (6), a current collector (7) and an electrolyte (3); the method comprises a step of operating the lithium ion battery (1) in a temperature range between 5 and 90° C.; and the electrolyte (3) contains: LiBOB as conducting salt and at least one selected from: PC and EC as solvent or LiFSI and/or LiDFOB as conducting salt and at least one glycol ether and/or DMC as solvent or LiFSI and/or LiTFSI and/or LiDFOB and/or LiTDI as conducting salt and at least one compound selected from: imidazolium compounds, pyrrolidinium compounds and piperidinium compounds as solvent.

Abstract: The invention relates to a grain for production of a refractory product, to the use of such grains, to a refractory product, to a process for producing a refractory product and to a refractory product produced thereby.

Abstract: A heatable battery includes a battery cell with an anode, a cathode, an anode connection which is connected to the anode, and a cathode connection which is connected to the cathode. The battery cell has a heating element and a connection for applying a voltage potential to the heating element. The heating element is connected to one of the components of the anode connection and the cathode connection. The battery cell further has a controllable switch which is arranged between the connection for applying the voltage potential to the heating element and the other of the components of the anode connection and the cathode connection.

Abstract: The storage module for an energy store of a motor vehicle includes multiple storage cells. The multiple storage cells are wired together according to a circuit topology and are electrically connected together for storing electric energy. Each storage cell has at least one electric heating element for heating the each storage cell. The heating elements are electrically connected to one another according to the same circuit topology.