Patents by Inventor Christoph Block
Christoph Block has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 12226136Abstract: A surgical guide production apparatus and accessories are provided to simplify the process of using the production apparatus within the surgical environment. A cutting attachment is provided for use on a surgical guide production apparatus. The cutting attachment comprises a cutting element, a connector for connecting the cutting element to a drive mechanism of the surgical guide production apparatus so that the cutting element can be driven by the drive mechanism to modify an impression of a surgical site to produce a surgical guide, and a protective barrier. The protective barrier is configured to be positioned around the cutting element to surround a cutting area to help prevent contaminants from entering or leaving the cutting area during modification of the impression.Type: GrantFiled: September 12, 2018Date of Patent: February 18, 2025Assignee: Prometheus Surgical LimitedInventors: George DeSoutter, William DeSoutter, Christopher Block
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Patent number: 12115704Abstract: According to an aspect of the invention there is provided a mouldable material carrier for use in producing an impression of a surgical site comprising: a base having a channel passing through the base between an inlet and an outlet; and a securing portion configured to secure a flexible sheet to the base around the outlet to cover the outlet such that, when mouldable material is urged through the inlet, the mouldable material is extruded out of the outlet and contained within a volume defined by the flexible sheet and the base, such that when the mouldable material carrier is urged against a surgical site, the mouldable material within the volume forms an impression of the surgical site without making contact with the surgical site.Type: GrantFiled: March 12, 2020Date of Patent: October 15, 2024Assignee: Prometheus Surgical LimitedInventors: George DeSoutter, William DeSoutter, Ryan Fenton, Christopher Block
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Publication number: 20220134624Abstract: According to an aspect of the invention there is provided a mouldable material carrier for use in producing an impression of a surgical site comprising: a base having a channel passing through the base between an inlet and an outlet; and a securing portion configured to secure a flexible sheet to the base around the outlet to cover the outlet such that, when mouldable material is urged through the inlet, the mouldable material is extruded out of the outlet and contained within a volume defined by the flexible sheet and the base, such that when the mouldable material carrier is urged against a surgical site, the mouldable material within the volume forms an impression of the surgical site without making contact with the surgical site.Type: ApplicationFiled: March 12, 2020Publication date: May 5, 2022Inventors: George DeSoutter, William DeSoutter, Ryan Fenton, Christopher Block
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Publication number: 20200262018Abstract: A surgical guide production apparatus and accessories are provided to simplify the process of using the production apparatus within the surgical environment. A cutting attachment is provided for use on a surgical guide production apparatus. The cutting attachment comprises a cutting element, a connector for connecting the cutting element to a drive mechanism of the surgical guide production apparatus so that the cutting element can be driven by the drive mechanism to modify an impression of a surgical site to produce a surgical guide, and a protective barrier. The protective barrier is configured to be positioned around the cutting element to surround a cutting area to help prevent contaminants from entering or leaving the cutting area during modification of the impression.Type: ApplicationFiled: September 12, 2018Publication date: August 20, 2020Inventors: George DeSoutter, William DeSoutter, Christopher Block
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Patent number: 8974767Abstract: The use of fluorescent nanoparticles is disclosed which includes an inorganic core, a passivating layer and specific ligands having a hydrodynamic diameter of the inorganic core with the passivating layer of not more than 15 nm, preferably of not more than 10 nm, particularly preferably of not more than 5 nm, for preparing an in vivo diagnostic aid, the nanoparticles showing an emission of less than 700 nm.Type: GrantFiled: November 16, 2006Date of Patent: March 10, 2015Assignee: Signalomics GmbHInventors: Sven Laarmann, Kathrin Zeller, Karin Mittmann, Christoph Block, Claudia Arntz
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Patent number: 8796200Abstract: The invention relates to optimized adhesins and nanoparticles to which said adhesins are bound. The invention furthermore relates to providing said nanoparticles by way of in vivo contrast agents, in particular for the diagnosis of bowel cancer.Type: GrantFiled: June 17, 2008Date of Patent: August 5, 2014Assignee: Signalomics GmbHInventors: Christoph Block, Karin Mittmann, Claudia Arntz
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Publication number: 20110237451Abstract: A method of identifying high-affinity ligands, comprising the following steps: a) generating a library for a mutagenized first hybrid protein, comprising a multiplicity of mutants; b) expressing said first hybrid protein in a host with a second hybrid protein, with one of said hybrid proteins comprising the DNA binding domain of a transcription factor and a bait protein, and the other hybrid protein comprising the activating domain for a transcription factor and a prey protein; c) enabling said first and second hybrid proteins to bind to one another to give a complex containing a functional transcription factor in the host cell under reaction conditions chosen so as to shift the equilibrium of the binding reaction toward the side of the hybrid proteins; d) detecting the binding reaction by detecting a reporter gene expressed via the functional transcription factor; e) optionally repeating one or more steps from a) to d); f) selecting a mutant.Type: ApplicationFiled: January 24, 2011Publication date: September 29, 2011Applicant: Signalomics GmbHInventors: Claudia Arntz, Danielle Meinders, Christoph Block
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Publication number: 20110110856Abstract: The invention relates to optimized adhesins and nanoparticles to which said adhesins are bound. The invention furthermore relates to providing said nanoparticles by way of in vivo contrast agents, in particular for the diagnosis of bowel cancer.Type: ApplicationFiled: June 17, 2008Publication date: May 12, 2011Applicant: Signalomics GmbHInventors: Christoph Block, Karin Mittmann, Claudia Arntz
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Publication number: 20100297772Abstract: Disclosed is a method for creating genetic diversity in vivo, comprising the following steps: fragments of at least one wild-type gene sequence are produced, each of said fragments being provided with at least one region which is homologous with a vector that is suitable for in vivo recombination; randomized bridging oligonucleotides of at least one defined oligonucleotide sequence are produced, parts of the bridging oligonucleotide being homologous with at least one fragment of the wild-type gene sequence; and the linearized vector, at least one wild-type fragment, and the randomized bridging oligonucleotide/s are introduced into an in vivo system for homologous recombination.Type: ApplicationFiled: October 16, 2006Publication date: November 25, 2010Applicant: SIGNALOMICS GMBHInventors: Christoph Block, Claudia Arntz
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Publication number: 20090239935Abstract: Method for the diagnosis of diseases in a mammal, preferably in a human, wherein a probe from the mammal is examined with a view to an elevated level of RNA helicase and the elevated level of RNA helicase indicates the disease. The disease refers to esophagus carcinoma, pancreas carcinoma, stomach carcinoma, hepatocellular carcinoma, hepatoblastoma and cholangiocellular carcinoma.Type: ApplicationFiled: December 14, 2006Publication date: September 24, 2009Applicants: Signalomics GMBH, Mayo Foundation for Medical Education and ResearchInventors: Kathrin Zeller, Sven Laarmann, Karin Mittmann, Christoph Block, Ralf Janknecht
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Publication number: 20090226371Abstract: The use of fluorescent nanoparticles comprising an inorganic core, a passivating layer and specific ligands having a hydrodynamic diameter of the inorganic core with the passivating layer of not more than 15 nm, preferably of not more than 10 nm, particularly preferably of not more than 5 nm, for preparing an in vivo diagnostic aid, the nanoparticles showing an emission of less than 700 nm.Type: ApplicationFiled: November 16, 2006Publication date: September 10, 2009Applicant: Signalomics GmbHInventors: Sven Laarmann, Kathrin Zeller, Karin Mittmann, Christoph Block, Claudia Arntz
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Publication number: 20090163370Abstract: The invention relates to a method for identifying highly affinous ligands comprising the following steps: a) creating a bank for a mutagenized first hybrid protein comprising a plurality of mutants; b) expression of a first hybrid protein in a host with a second hybrid protein, one of the hybrid proteins comprising the DNA binding domain of a transcription factor and a bait protein and the other hybrid protein comprising the activation domain for a transcription factor and a prey protein; c) allowing the binding reaction between the first and second hybrid protein in order to form a complex with a functional transcription factor in the host cell under reaction conditions, which are such that the balance of the binding reaction is offset on the side of the hybrid proteins; d) detecting the binding reaction by detecting a reporter gene expressed via the functional transcription factor; e) optionally repeating one or more steps from a) to d); f) selection of a mutant.Type: ApplicationFiled: May 4, 2006Publication date: June 25, 2009Applicant: Signalomics gmbHInventors: Claudia Arntz, Danielle Meinders, Christoph Block