Abstract: The present invention relates to novel bis-sulfonamides represented, for example, by formula I below and a pure diastereomer, a mixture of diastereomers, a diastereomeric racemate, a mixture of diastereomeric racemates and meso-forms and a pharmaceutically acceptable salt thereof, wherein R1 represents aryl; aryl-lower alkyl; aryl-lower alkenyl; heteroaryl; or heteroaryl-lower alkyl; and R2 represents lower alkyl; trifluoromethyl; lower alkoxy-lower alkyl; lower alkenyl; lower alkynyl; aryl; aryl-lower alkyl; aryl-lower alkenyl; heterocyclyl; heterocyclyl-lower alkyl; heteroaryl; heteroaryl-lower alkyl; cycloalkyl; or cycloalkyl-lower alkyl. The present invention also relates to a process for manufacturing those compounds, pharmaceutical compositions containing one or more of those compounds as endothelin antagonists, and a method of treating a subject having a disorder involving endothelin with the compounds of the invention.

Abstract: The present invention relates to novel butyne diol derivatives of the general formula I and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of the compounds, pharmaceutical compositions containing one or more compounds of the general formula I and especially their use as endothelin receptor antagonists.

Abstract: A drive apparatus (5) is proposed, consisting of a drive casing (12) and a gear casing (19), in which the two casings (12, 19) are screwed to one another in a centered position and to the frame transverse component (2) with the incorporation between them of a plane wall of the front transverse frame portion (2) of a guide frame (1). The drive casing (12), preferably injection moulded in one piece from a wear-resistant, thermoplastics material, guides two drive cables (8, 9) with guide channels (15, 16) slender in the central portion (15) over such a length that the drive cables (8, 9) can emerge at both ends virtually free of lateral pressure from the drive casing (12) and enter the drive cable guides of the frame transverse portion (2). The drive casing (12) makes possible sliding movements of the drive cables guided with low radial clearance without noise caused by joint positions.