Abstract: The present invention provides a basal cell culture medium and a feed medium with novel amino acid ratios and/or iron choline citrate as iron carrier that result in improved performance of mammalian cell culture processes, such as CHO cultivation and protein production processes, in particular in increased product titer (e.g. of monoclonal antibodies). Also provided are methods for culturing mammalian cells and producing a protein of interest using said basal cell culture medium and optionally feed medium. The invention also provides for a medium platform that comprises (i) the basal cell culture medium and (ii) the feed medium.

Abstract: The present invention provides a basal cell culture medium and a feed medium with novel amino acid ratios and/or iron choline citrate as iron carrier that result in improved performance of mammalian cell culture processes, such as CHO cultivation and protein production processes, in particular in increased product titer (e.g. of monoclonal antibodies). Also provided are methods for culturing mammalian cells and producing a protein of interest using said basal cell culture medium and optionally feed medium. The invention also provides for a medium platform that comprises (i) the basal cell culture medium and (ii) the feed medium.

Abstract: The present invention provides a basal cell culture medium and a feed medium with novel amino acid ratios and/or iron choline citrate as iron carrier that result in improved performance of mammalian cell culture processes, such as CHO cultivation and protein production processes, in particular in increased product titer (e.g. of monoclonal antibodies). Also provided are methods for culturing mammalian cells and producing a protein of interest using said basal cell culture medium and optionally feed medium. The invention also provides for a medium platform that comprises (i) the basal cell culture medium and (ii) the feed medium.

Abstract: An embodiment of the invention relates to a system comprising an optical device (10) and an evaluation device (20) for characterizing the optical device. The optical device comprising a 90° optical hybrid unit (30) having a first and second optical input (30E1, 30E2) and at least two optical outputs (30A1-30A4) wherein optical output signals (So1-So4) leaving the optical outputs have optical phase differences between each other of 90° or multiple thereof; a first photodetector (P1) connected to a first optical output (30A1) and a second photodetector (P2) connected to a second optical output (30A2), wherein the first optical output emits a first optical output signal (So1) and the second optical output emits a second optical output signal (So2), said second optical output signal having an optical phase difference of 180° relative to the first optical output signal; and a first transimpedance amplifier (Tr1) connected to the first and second photodetectors (P1, P2).

Abstract: An embodiment of the invention relates to a system comprising an optical device (10) and an evaluation device (20) for characterizing the optical device. The optical device comprising a 90° optical hybrid unit (30) having a first and second optical input (30E1, 30E2) and at least two optical outputs (30A1-30A4) wherein optical output signals (So1-So4) leaving the optical outputs have optical phase differences between each other of 90° or multiple thereof; a first photodetector (P1) connected to a first optical output (30A1) and a second photodetector (P2) connected to a second optical output (30A2), wherein the first optical output emits a first optical output signal (So1) and the second optical output emits a second optical output signal (So2), said second optical output signal having an optical phase difference of 180° relative to the first optical output signal; and a first transimpedance amplifier (Tr1) connected to the first and second photodetectors (P1, P2).

Abstract: The invention proposes a much improved X-ray scanner for large objects. These relate to both safety aspects for the service personnel of the system and safety aspects for the operating personnel of the large object to be scanned, as well as aspects which make possible improved image acquisition.

Abstract: A method, computer system and computer program for analyzing geological data sampled from a subsurface region stored in a geoscience model on a computer-readable media including defining consistency; detecting an inconsistency; and resolving the inconsistency.