Patents by Inventor Christoph Dehnhardt

Christoph Dehnhardt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the synthesis C-2, C-3 substituted N-alkylated indoles useful as cPLAinhibitors
    Patent number: 8034960
    Abstract: The present invention provides a compound of formula 1: wherein R1 is CF3, R2 is H? R3 is H.
    Type: Grant
    Filed: November 11, 2010
    Date of Patent: October 11, 2011
    Assignee: Pfizer Inc.
    Inventors: Ronald S. Michalak, Mahmut Levent, Frederick J. Vyverberg, Ara R. Boyajian, Panolil Raveendranath, Michel Cantin, Alan Stockton, Michael W. Winkley, Mousumi Ghosh, Christoph Dehnhardt, Charles Guinosso
  • Process For The Synthesis C-2, C-3 Substituted N-Alkylated Indoles Useful As CPLA2 Inhibitors
    Publication number: 20110054189
    Abstract: The present invention provides a compound of formula 1: wherein R1 is CF3, R2 is H, R3 is H, and R4 is H.
    Type: Application
    Filed: November 11, 2010
    Publication date: March 3, 2011
    Inventors: Ronald S. Michalak, Mahmut Levent, Frederick J. Vyverberg, Ara R. Boyajian, Panolil Raveendranath, Michel Cantin, Alan Stockton, Michael W. Winkley, Mousumi Ghosh, Christoph Dehnhardt, Charles Guinosso
  • Process for the synthesis of C-2, C-3 substituted N-alkylated indoles useful as cPLAinhibitors
    Patent number: 7842837
    Abstract: The present invention provides method for making a compound of formula 1: comprising the steps of reacting compounds of formulas 2 and 3: to produce a compound of formula 4: wherein R1, R2, R3, R4 and R5 are defined as described herein. The compound of formula 4 is then converted to the compound of formula 1. The invention further comprises compounds of formulas 3 and 4 and methods for making compounds of formulas 3 and 4.
    Type: Grant
    Filed: August 18, 2009
    Date of Patent: November 30, 2010
    Assignee: Wyeth LLC
    Inventors: Ronald S. Michalak, Mahmut Levent, Frederick J. Vyverberg, Ara R. Boyajian, Panolil Raveendranath, Michel Cantin, Alan Stockton, Michael W. Winkley, Mousumi Ghosh, Christoph Dehnhardt, Charles Guinosso
  • Process for preparing quinoline compounds and products obtained therefrom
    Patent number: 7781427
    Abstract: Methods for synthesizing tetrahydroquinoline-containing compounds are provided, along with synthetic intermediates and products associated with such methods.
    Type: Grant
    Filed: November 4, 2005
    Date of Patent: August 24, 2010
    Assignee: Wyeth LLC
    Inventors: Christoph Dehnhardt, Sreenivasulu Megati, Jerry Sun
  • PROCESS FOR PREPARING QUINOLINE COMPOUNDS AND PRODUCTS OBTAINED THEREFROM
    Publication number: 20100196714
    Abstract: Methods for synthesizing tetrahydroquinoline-containing compounds are provided, along with synthetic intermediates and products associated with such methods.
    Type: Application
    Filed: April 7, 2010
    Publication date: August 5, 2010
    Applicant: Wyeth
    Inventors: Christoph Dehnhardt, Sreenivasulu Megati, Jerry Sun
  • Process for the Synthesis of C-2, C-3 Substituted N-Alkylated Indoles Useful as cPLA2 Inhibitors
    Publication number: 20090306428
    Abstract: The present invention provides method for making a compound of formula 1: comprising the steps of reacting compounds of formulas 2 and 3: to produce a compound of formula 4: wherein R1, R2, R3, R4 and R5 are defined as described herein. The compound of formula 4 is then converted to the compound of formula 1. The invention further comprises compounds of formulas 3 and 4 and methods for making compounds of formulas 3 and 4.
    Type: Application
    Filed: August 18, 2009
    Publication date: December 10, 2009
    Inventors: Ronald S. Michalak, Mahmut Levent, Frederick J. Vyverberg, Ara R. Boyajian, Panolil Raveendranath, Michel Cantin, Alan Stockton, Michael W. Winkley, Mousumi Ghosh, Christoph Dehnhardt, Charles Guinosso
  • Process for the synthesis C-2, C-3 substituted N-alkylated indoles useful as CPLAinhibitors
    Patent number: 7582772
    Abstract: The present invention provides method for making a compound of formula 1: comprising the steps of reacting compounds of formulas 2 and 3: to produce a compound of formula 4: wherein R1, R2, R3, R4 and R5 are defined as described herein. The compound of formula 4 is then converted to the compound of formula 1. The invention further comprises compounds of formulas 3 and 4 and methods for making compounds of formulas 3 and 4.
    Type: Grant
    Filed: August 18, 2005
    Date of Patent: September 1, 2009
    Assignee: Wyeth
    Inventors: Ronald S. Michalak, Mahmut Levent, Frederick J. Vyverberg, Ara R. Boyajian, Panolil Raveendranath, Michel Cantin, Alan Stockton, Michael W. Winkley, Mousumi Ghosh, Christoph Dehnhardt, Charles Guinosso
  • CHIRAL SYNTHESIS OF DIAZEPINOQUINOLINES
    Publication number: 20090093630
    Abstract: The present invention relates to improved methods of resolution and recrystallization for synthesizing compounds useful as 5HT2C agonists or partial agonists, including intermediates thereto.
    Type: Application
    Filed: September 19, 2008
    Publication date: April 9, 2009
    Applicant: Wyeth
    Inventors: Sreenivasulu Megati, Shilpa Bhansali, Christoph Dehnhardt, Subodh Deshmukh, Peter Fung, Michael MacEwan, Robert J. Tinder
  • AMINO-SUBSTITUTED QUINAZOLINE DERIVATIVES AS INHIBITORS OF BETA-CATENIN/TCF-4 PATHWAY AND CANCER TREATMENT AGENTS
    Publication number: 20090004185
    Abstract: The present invention relates to amino-substituted quinazoline derivatives as inhibitors of ?-catenin/tcf-4 pathway, which can be useful in the treatment of cancer; to processes for their preparation; to pharmaceutical compositions comprising them; and to methods of using them.
    Type: Application
    Filed: January 10, 2008
    Publication date: January 1, 2009
    Applicant: WYETH
    Inventors: Aranapakam M. VENKATESAN, Christoph DEHNHARDT, Zecheng CHEN, Osvaldo Dos SANTOS, Efren Delos SANTOS, Kevin CURRAN, Semiramis AYRAL-KALOUSTIAN, Lei CHEN
  • Amino-chroman compounds and methods for preparing same
    Publication number: 20060205807
    Abstract: The present invention relates to novel amino-chroman compounds, methods of preparing such compounds, and to synthetic intermediates useful in such methods.
    Type: Application
    Filed: February 16, 2006
    Publication date: September 14, 2006
    Applicant: Wyeth
    Inventors: Christoph Dehnhardt, Sylvain Daigneault
  • Process for preparing quinoline compounds and products obtained therefrom
    Publication number: 20060122385
    Abstract: Methods for synthesizing tetrahydroquinoline-containing compounds are provided, along with synthetic intermediates and products associated with such methods.
    Type: Application
    Filed: November 4, 2005
    Publication date: June 8, 2006
    Applicant: Wyeth
    Inventors: Christoph Dehnhardt, Sreenivasulu Megati, Jerry Sun
  • Process for the synthesis C-2, C-3 substituted N-alkylated indoles useful as CPLA2 inhibitors
    Publication number: 20060041005
    Abstract: The present invention provides method for making a compound of formula 1: comprising the steps of reacting compounds of formulas 2 and 3: to produce a compound of formula 4: wherein R1, R2, R3, R4 and R5 are defined as described herein. The compound of formula 4 is then converted to the compound of formula 1. The invention further comprises compounds of formulas 3 and 4 and methods for making compounds of formulas 3 and 4.
    Type: Application
    Filed: August 18, 2005
    Publication date: February 23, 2006
    Applicant: Wyeth
    Inventors: Ronald Michalak, Mahmut Levent, Frederick Vyverberg, Ara Boyajian, Panolil Raveendranath, Michel Cantin, Alan Stockton, Michael Winkley, Mousumi Ghosh, Christoph Dehnhardt, Charles Guinosso
  • Process for the synthesis of a CPLA2 inhibitor
    Publication number: 20050070723
    Abstract: A process for making a substituted indole compound, including the steps of: reacting the compounds in a non-protic polar solvent in the presence of a catalyst to form the intermediate compound wherein Ph and X are as defined herein; and then, heating this intermediate compound in the solvent in the presence of the catalyst to form the substituted indole compound The invention also includes compounds formed by this process.
    Type: Application
    Filed: September 23, 2004
    Publication date: March 31, 2005
    Applicant: Wyeth Holdings Corporation
    Inventors: Christoph Dehnhardt, Sreenivasulu Megati, Ronald Michalak, Panolil Raveendranath
  • Process for the synthesis of cPLA2 inhibitors
    Publication number: 20050049296
    Abstract: A process for making the compound of formula (I) wherein Ac represents acetate; X represents O or CH2; Y represents C1-C6alkyl; and Z is selected from the group consisting of H, halogen, CN, CHO, CF3, OCF3, OH, C1-C6alkyl, C1-C6alkoxy, C1-C6thioalkyl, NH2, N(C1-C6alkyl)2, NH(C1-C6alkyl), NC(O)-(C1-C6alkyl), and NO2. In his process, a compound of formula (II) is reacted with hydrazine to form a primary alkylamine, and then the primary alkylamine is reacted with acetic anhydride, to produce the compound of formula (I).
    Type: Application
    Filed: August 31, 2004
    Publication date: March 3, 2005
    Applicant: Wyeth
    Inventors: Christoph Dehnhardt, Sreenivasulu Megati, Ronald Michalak, Panolil Raveendranath, Jianxin Ren, Charles Wu, Yangzhong Wu