Abstract: A method for concentrating materials in a liquid involves pouring the liquid into a material-containing receptacle and irradiating the liquid by acoustic waves so that a stationary flow pattern with different flow rate areas is formed in the receptacle. A concentration device and reaction method using such concentration are also provided.

Abstract: The invention relates to a mixing method for mixing at least one small quantity of liquid, in which a quantity of liquid is applied in a reaction region and at least one surface sound wave is reacted with the quantity of liquid. The invention relates further to a mixing device for mixing at least one quantity of liquid for performing the method of the present invention, a use of the device, and a method of analysis for bond strengths on surfaces.

Abstract: A method or device for integrated dosing and intermixing of small amounts of liquid, has a first liquid conveyed into or onto a first reservoir (3). A second reservoir (1) is entirely filled with a second liquid. The first and second liquids are brought into contact with each other via at least one joining duct structure (5) which has at least one area provided with a smaller cross section than the reservoirs (1,3) in the viewing direction of the connecting line between the two reservoirs (1,3). A laminar flow pattern is created along at least one portion of the joining duct structure (5), with the liquids thoroughly mixed in the second reservoir (1).

Abstract: The invention relates to a mixing method for mixing at least one small quantity of liquid, in which a quantity of liquid is applied, in a reaction region and at least one surface sound wave is reacted with the quantity of liquid. The invention relates further to a mixing device for mixing at least one quantity of liquid for performing the method of the present invention, a use of the device, and a method of analysis for bond strengths on surfaces.

Abstract: A method or device for integrated dosing and intermixing of small amounts of liquid, has at least one dosing reservoir (3) connected to a reaction reservoir (1) via at least one joining structure (11) and entirely filled with a first liquid. The at least one joining structure (11) is preferably dimensioned such that surface tension of the first liquid prevents the first liquid from penetrating into the reaction reservoir (1) which is entirely filled with a second liquid contacting the first liquid on the joining structure (11). A flow pattern is created in or on the reaction reservoir (1) to thoroughly mix the two liquids.

Abstract: The present Invention relates to a process for determining the genotype of one or more individuals from a biological sample which contains nucleic acids from different individuals, in particular a process for determining the number of copies of a predetermined sequence, in which first using at least two subquantities of the biological sample of different concentrations, in each case at least one amplification reaction is carried out, subsequently the number of the different amplification products obtained for each of the at least two subquantities is determined and compared with one another, and finally the amplification products which were obtained only for one defined subquantity and/or those amplification products which were obtained for all subquantities, are characterized. In addition, the present invention relates to a kit for carrying out the process according to the invention.

Abstract: The invention relates to a method for carrying out an enzymatic reaction, in particular for carrying out a polymerase chain reaction (PCR). Said method consists of the following steps: at least one eukaryotic cell is removed from a starting material; the cell core or cores of the eukaryotic cell(s) is/are coloured; at least one eukaryotic cell is deposited on a reaction point of a solid substrate in a liquid volume of less than 10 ?l; it is detected whether at least one coloured cell core is present on a reaction point of the substrate, subsequently, an enzyme and optionally a reaction buffer is added to the eukaryotic cell(s) and the enzymatic reaction is subsequently started. Preferably, the claimed invention is carried out using a flow cytometer.

Abstract: A method or device for integrated dosing and intermixing of small amounts of liquid, has at least one dosing reservoir (3) connected to a reaction reservoir (1) via at least one joining structure (11) and entirely filled with a first liquid. The at least one joining structure (11) is preferably dimensioned such that surface tension of the first liquid prevents the first liquid from penetrating into the reaction reservoir (1) which is entirely filled with a second liquid contacting the first liquid on the joining structure (11). A flow pattern is created in or on the reaction reservoir (1) to thoroughly mix the two liquids.

Abstract: A method is provided for characterizing a mixed sample having at least two particles with nucleic acids from different individuals, where each particle has nucleic acid from one or more individuals, in particular for the quantitative determination of the absolute and/or relative copy number of a predetermined sequence of an individual, of which nucleic acid is present in the mixed sample, having the steps: a) isolating the particles and applying at least two individual particles to a substrate, where each of the at least two particles is deposited in each case individually to a hydrophilic reaction site, surrounded by a hydrophobic zone, of the substrate in a volume of less than 10 ?l so that precisely one particle is present per reaction site, b) analysis of at least two of the particles deposited to the substrate at the reaction site of the substrate to assign each of the particles to individuals from the mixed sample by genotyping, where at least 80% of the particles analysed are to be assigned to an indi

Abstract: The invention relates to a method for the quantitative analysis of the number of a pre-determined sequence, and optionally of sequences homologous to the pre-determined sequence, in a biological sample, whereby a defined quantity of a biological sample is subjected to at least one amplification reaction which is adapted in such a way as to amplify at least two non-homologous sequences contained in the pre-determined sequence. The number of different amplification products obtained is then determined and compared with a frequency distribution. The invention further relates to a kit for the quantitative analysis of the number of a pre-determined sequence in a biological sample, and a device which is especially suitable for carrying out the inventive method.

Abstract: A method for concentrating materials in a liquid involves pouring the liquid into a material-containing receptacle and irradiating the liquid by acoustic waves so that a stationary flow pattern with different flow rate areas is formed in the receptacle. A concentration device and reaction method using such concentration are also provided.

Abstract: The invention relates to a method for the analysis of macromolecules using a microarray on which a plurality of first at least partly different macromolecules are located in a known arrangement, wherein the microarray is arranged on a solid surface on which a region is defined whose wetting properties differ from the surrounding solid surface such that a liquid with a plurality of second macromolecules preferably stays thereon, the liquid with the second macromolecules is brought onto the solid surface and at least partly removed and the second macromolecules remaining after the removal process are detected in order to determine from the position which of the first macromolecules have formed a bond with second macromolecules. The invention further relates to a method wherein a surface wave is launched to the liquid to distribute and/or thoroughly mix the liquid on the microarray.

Abstract: A method is provided for displacing small amounts of fluids in micro channels, in which an amount of fluid is introduced into a channel system which has at least one area which corresponds in a topological manner to a ring, such that a closed path of the fluid is possible, and acoustic waves, which have at least one asymmetrical component on the plane of the channel system, are radiated into the fluid, this component defining the direction of displacement of the fluid. A micro channel system for carrying out the method is also provided.

Abstract: The invention relates to a method for determining the abundance of a given sequence or several sequences identical or nearly identical to the given sequence in a sample. The method comprises the following steps: carrying out one or more amplification reactions by means of which several different sections of the sequence or sequences of the sample can be amplified to give an amplified product, detection of whether given different sections of the sequence in the sample have been amplified and determination of the number of the sequence(s) in the sample by means of the abundance of the presence or otherwise of the given different sections in the amplified product.

Abstract: A method or device for integrated dosing and intermixing of small amounts of liquid, has a first liquid conveyed into or onto a first reservoir (3). A second reservoir (1) is entirely filled with a second liquid. The first and second liquids are brought into contact with each other via at least one joining duct structure (5) which has at least one area provided with a smaller cross section than the reservoirs (1,3) in the viewing direction of the connecting line between the two reservoirs (1,3). A laminar flow pattern is created along at least one portion of the joining duct structure (5), with the liquids thoroughly mixed in the second reservoir (1).

Abstract: The invention relates to a sample support washing container for simultaneous washing of at least two sample slides, with a filling opening, through which the sample slides can be introduced, a liquid supply opening or respectively discharge opening substantially opposite the filling opening and sample slide holding devices, arranged in the washing container such that they can keep the introduced sample slides apart, and a liquid discharge space remains between the introduced sample slides and the liquid supply opening or respectively discharge opening.

Abstract: The invention relates to a titration method for extremely small quantities of liquid wherein a drop of an analyte held together by its surface tension is applied to the substantially flat surface of a solid, preferably a solid chip, a quantity of the titrant which is smaller than the quantity of the analyte drop, is brought in contact with the analyte drop for the reaction and a characteristic quantity for the reaction between titrant and analyte is measured during and/or after the reaction.

Abstract: The invention relates to a motion element for producing motion in small quantities of liquid comprising a plate-shaped member having two principal surfaces, wherein at least one motion device, which is electrically controllable, is arranged on a first active principal surface to set in motion a liquid which is in contact with the active principal surface, and electrical contact elements for the motion device. The invention furthermore relates to a motion device which can be used with the motion element according to the invention, a cartridge to receive a motion element according to the invention, a reaction device to receive a cartridge according to the invention and a method for producing motion in small quantities of liquid.

Abstract: The invention relates to a mixing method for mixing at least one small quantity of liquid, in which a quantity of liquid is applied in a reaction region and at least one surface sound wave is reacted with the quantity of liquid. The invention relates further to a mixing device for mixing at least one quantity of liquid for performing the method of the present invention, a use of the device, and a method of analysis for bond strengths on surfaces.

Abstract: The invention relates to a method for the analysis of macromolecules using a microarray on which a plurality of first at least partly different macromolecules are located in a known arrangement, wherein the microarray is arranged on a solid surface on which a region is defined whose wetting properties differ from the surrounding solid surface such that a liquid with a plurality of second macromolecules preferably stays thereon, the liquid with the second macromolecules is brought onto the solid surface and at least partly removed again and the second macromolecules remaining after the removal process are detected in a spatially resolved fashion in order to determine from the position which of the first macromolecules have formed a bond with second macromolecules. The invention further relates to a method wherein a surface wave is launched to the liquid to distribute and/or thoroughly mix the liquid on the microarray, and a device for implementing the method according to the invention and advantageous uses.