Patents by Inventor Christoph Gebhardt
Christoph Gebhardt has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 10593532Abstract: The invention relates to a liquid junction apparatus for electrospray ionization in a mass spectrometer comprising an electrospray emitter, a capillary conduit assembly for conducting liquid to be electrosprayed, and a union comprising an electrically conductive material, in which the electrospray emitter and the capillary conduit assembly are accommodated in a bottom-sealing butt joint featuring low dead volume while retaining at least one of them pluggable and withdrawable. The liquid junction apparatus facilitates energizing the transmitted liquid to a predetermined voltage level at the liquid junction upstream of an actual emitter tip where electrospraying occurs, while retaining at least one of an electrospray emitter and a capillary conduit assembly pluggable into and withdrawable from a union that comprises a conductive material.Type: GrantFiled: February 18, 2019Date of Patent: March 17, 2020Inventors: Christoph Gebhardt, Peter Aagaard Nielsen, Ralph Kikillus, Christian Meier-Credo
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Patent number: 10551360Abstract: A low dead-volume connector for fluid chromatography, such as liquid chromatography and gas chromatography, has a female assembly including a receiving member being designed and configured to receive, and releasably interlock with, a male assembly. The connector is particularly suited for high performance liquid chromatography (HPLC) applications.Type: GrantFiled: October 11, 2016Date of Patent: February 4, 2020Inventors: Peter A. Nielsen, Nicolai Bache, Christoph Gebhardt, Ralph Kikillus
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Publication number: 20190259597Abstract: The invention relates to a liquid junction apparatus for electrospray ionization in a mass spectrometer comprising an electrospray emitter, a capillary conduit assembly for conducting liquid to be electrosprayed, and a union comprising an electrically conductive material, in which the electrospray emitter and the capillary conduit assembly are accommodated in a bottom-sealing butt joint featuring low dead volume while retaining at least one of them pluggable and withdrawable. The liquid junction apparatus facilitates energizing the transmitted liquid to a predetermined voltage level at the liquid junction upstream of an actual emitter tip where electrospraying occurs, while retaining at least one of an electrospray emitter and a capillary conduit assembly pluggable into and withdrawable from a union that comprises a conductive material.Type: ApplicationFiled: February 18, 2019Publication date: August 22, 2019Inventors: Christoph GEBHARDT, Peter Aagaard NIELSEN, Ralph KIKILLUS, Christian MEIER-CREDO
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Patent number: 10335793Abstract: The invention generally relates to a connector for fluid chromatography, such as gas chromatography and liquid chromatography, having a female assembly including a receiving member being designed and configured to receive, and releasably interlock with, a male assembly. The connector is particularly suited for high performance liquid chromatography (HPLC) applications.Type: GrantFiled: March 4, 2016Date of Patent: July 2, 2019Inventors: Nicolai Bache, Christoph Gebhardt, Ole Bjeld Hoerning, Ralph Kikillus, Frank Hirmer, Peter Aagaard Nielsen
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Publication number: 20180100837Abstract: The invention generally relates to a low dead-volume connector for fluid chromatography, such as liquid chromatography and gas chromatography, having a female assembly including a receiving member being designed and configured to receive, and releasably interlock with, a male assembly. The connector is particularly suited for high performance liquid chromatography (HPLC) applications.Type: ApplicationFiled: October 11, 2016Publication date: April 12, 2018Inventors: Peter A. NIELSEN, Nicolai BACHE, Christoph GEBHARDT, Ralph KIKILLUS
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Publication number: 20170252746Abstract: The invention generally relates to a connector for fluid chromatography, such as gas chromatography and liquid chromatography, having a female assembly including a receiving member being designed and configured to receive, and releasably interlock with, a male assembly. The connector is particularly suited for high performance liquid chromatography (HPLC) applications.Type: ApplicationFiled: March 4, 2016Publication date: September 7, 2017Inventors: Nicolai BACHE, Christoph GEBHARDT, Ole Bjeld HOERNING, Ralph KIKILLUS, Frank HIRMER
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Patent number: 9263223Abstract: The invention relates to devices and methods in mass spectrometers for the generation of ions of heavy molecules, especially biomolecules, by bombarding them with uncharged clusters of molecules. The analyte ions which are generated or released by cluster bombardment of analyte substances on the surface of sample support plates show a broad distribution of their kinetic energies, which prevents good ion-optical focusing. In the invention, the kinetic energies are homogenized in a higher-density collision gas. The collision gas is preferably located in an RF ion guide, more preferably an RF ion funnel, which can transfer the ions to the mass analyzer. The collision gas may be introduced with temporal pulsing, coordinated or synchronized with the pulsed supersonic gas jet. The collision gas may be pumped off again before the next supersonic gas pulse. In an advantageous embodiment, the collision gas can originate from the supersonic gas jet itself.Type: GrantFiled: April 25, 2013Date of Patent: February 16, 2016Inventors: Michael Duerr, Christoph Gebhardt
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Patent number: 8901491Abstract: The invention proposes a method for the collective ejection of ions from a 3D RF ion trap with a ring electrode and two end cap electrodes, which comprises the following steps: (a) the RF voltage of a high-quality resonant circuit applied to the ring electrode is replaced with a second RF voltage at the two end cap electrodes which can be changed or switched faster than the high voltage at the ring electrode, keeping the ions stored, (b) the second RF voltage at the end cap electrodes is then switched down or off abruptly, releasing the ions, and (c) the released ions are ejected through an opening in one of the end cap electrodes by switching on a DC voltage on at least one of the end cap electrodes.Type: GrantFiled: June 26, 2013Date of Patent: December 2, 2014Assignee: Bruker Daltonik, GmbHInventors: Andreas Brekenfeld, Christoph Gebhardt, Ralf Hartmer
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Publication number: 20140008533Abstract: The invention proposes a method for the collective ejection of ions from a 3D RF ion trap with a ring electrode and two end cap electrodes, which comprises the following steps: (a) the RF voltage of a high-quality resonant circuit applied to the ring electrode is replaced with a second RF voltage at the two end cap electrodes which can be changed or switched faster than the high voltage at the ring electrode, keeping the ions stored, (b) the second RF voltage at the end cap electrodes is then switched down or off abruptly, releasing the ions, and (c) the released ions are ejected through an opening in one of the end cap electrodes by switching on a DC voltage on at least one of the end cap electrodes.Type: ApplicationFiled: June 26, 2013Publication date: January 9, 2014Inventors: Andreas Brekenfeld, Christoph Gebhardt, Ralf Hartmer
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Publication number: 20130285552Abstract: The invention relates to devices and methods in mass spectrometers for the generation of ions of heavy molecules, especially biomolecules, by bombarding them with uncharged clusters of molecules. The analyte ions which are generated or released by cluster bombardment of analyte substances on the surface of sample support plates show a broad distribution of their kinetic energies, which prevents good ion-optical focusing. In the invention, the kinetic energies are homogenized in a higher-density collision gas. The collision gas is preferably located in an RF ion guide, more preferably an RF ion funnel, which can transfer the ions to the mass analyzer. The collision gas may be introduced with temporal pulsing, coordinated or synchronized with the pulsed supersonic gas jet. The collision gas may be pumped off again before the next supersonic gas pulse. In an advantageous embodiment, the collision gas can originate from the supersonic gas jet itself.Type: ApplicationFiled: April 25, 2013Publication date: October 31, 2013Applicant: Bruker Daltonik GmbHInventors: Michael Duerr, Christoph Gebhardt
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Patent number: 8324566Abstract: In an RF quadrupole ion trap having electrodes to which RF voltages are applied, ions having m/z ratios outside of a predefined narrow range of charge-related masses m/z are removed from the trap by applying a DC voltage pulse to at least one of the trap electrodes to remove from the trap the ions with high values of charge-related masses. The DC voltage pulse is preferably applied in combination with a variation of the RF voltage amplitudes to simultaneously remove from the trap ions of low charge-related masses. The DC and RF voltage amplitudes are changed in such a manner that any excitation of ions having charge-related masses within the predefined range by frequency mixtures is avoided.Type: GrantFiled: March 1, 2011Date of Patent: December 4, 2012Assignee: Bruker Daltonik GmbHInventors: Desmond Allen Kaplan, Andreas Brekenfeld, Christoph Gebhardt, Ralf Hartmer
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Publication number: 20120223222Abstract: In an RF quadrupole ion trap having electrodes to which RF voltages are applied, ions having m/z ratios outside of a predefined narrow range of charge-related masses m/z are removed from the trap by applying a DC voltage pulse to at least one of the trap electrodes to remove from the trap the ions with high values of charge-related masses. The DC voltage pulse is preferably applied in combination with a variation of the RF voltage amplitudes to simultaneously remove from the trap ions of low charge-related masses. The DC and RF voltage amplitudes are changed in such a manner that any excitation of ions having charge-related masses within the predefined range by frequency mixtures is avoided.Type: ApplicationFiled: March 1, 2011Publication date: September 6, 2012Applicant: BRUKER DALTONIK GMBHInventors: Desmond Allen Kaplan, Andreas Brekenfeld, Christoph Gebhardt, Ralf Hartmer
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Patent number: 7247845Abstract: A method for cluster fragmentation comprises the production of at least one cluster which contains a carrier substance and the fragmentation of the cluster into cluster fragments, with the cluster being loaded before the fragmentation with at least one reaction partner and the reaction partner being part of at least one cluster fragment after the fragmentation. A cluster beam system for performing the method, and applications of the cluster fragmentation for analysis and purification of surfaces, for analysis of clusters, and for the operation of ion thrusters are also described.Type: GrantFiled: July 20, 2000Date of Patent: July 24, 2007Assignee: Max-Planck Gesellschaft zur Forderung der Wissenschaften e.V.Inventors: Christoph Gebhardt, Hartmut Schroder
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Publication number: 20060289737Abstract: The invention relates to a mass spectrometric mixture analysis to determine both simple mass spectra of the substances as well as more detailed information about structures and other characteristics of the substances. The invention consists in temporally separating the substance mixture in a separating device, splitting the eluating flow of substances into at least two partial flows and measuring the substances in the different partial flows by mass spectrometry. A direct measurement provides a series of spectra whose evaluation is used for optimal control of the time at which a spectrum of another, delayed partial flow is acquired and the type of this measurement procedure. The substances of the delayed partial flows or their ions can thereby be chemically or physically modified in a variety of ways in order to provide the molecular weight as well as more detailed information.Type: ApplicationFiled: May 26, 2006Publication date: December 28, 2006Applicant: Bruker Daltonik GmbHInventors: Carsten Bassmann, Markus Lubeck, Christoph Gebhardt, Thorsten Ledertheil