Abstract: The invention relates to the treatment and prevention of diseases and conditions associated with EBV infection. In particular, the invention is directed to the use of an IDO1 inhibitor for the treatment and prevention of diseases and conditions associated with EBV infection. The invention also relates to methods for predicting the risk of developing a disease or condition associated with EBV infection.

Abstract: The present invention relates to an LFA-1 signalling mediator with moderate LFA-1 stabilization properties for use in cancer immunotherapy or a composition for use in cancer immunotherapy comprising an immune system modulator, wherein the immune system modulator enhances the immune response against cancer, and an LFA-1 signalling mediator with moderate LFA-1 stabilization properties wherein the LFA-1 signalling mediator selectively and significantly enhances the anti-cancer immune response. The composition may comprise a carrier for target delivery of the composition.

Abstract: The invention relates to the actuation of a converter lock-up clutch (44) of a hydrodynamic torque converter (4) in a vehicle drive-train by means of a safety function where, in addition to a driving strategy function, the safety function can actuate the converter lock-up clutch (44) by issuing a clutch actuation command. For this purpose, at least one rotation speed at the torque converter (4) is monitored. If the monitored rotation speed is below a rotation speed threshold, the safety function commands an actuation of the converter lock-up clutch (44) in its opening direction.

Abstract: A gradient index lens includes at least one optical material, wherein the optical material has at least two extension axes at an angle relative to one another, wherein the optical material has a refractive index gradient along at least one of the extension axes the optical material, and wherein the optical material is formed to be coiled around at least one of the extension axes.

Abstract: The present invention is in the field of cell therapy and provides compositions and methods for treating cancer and/or viral infections in patients. The invention provides lymphocytes comprising a synthetic polynucleotide encoding at least one iron regulatory protein and, optionally, a chimeric antigen receptor. The invention further provides methods for producing these lymphocytes and administering them to patients.

Abstract: A multi-layer polymer film comprising at least one middle layer A, the polymeric constituents of which are soluble in aqueous solution, and at least one substantially water-impermeable covering layer B or C arranged above and/or below the at least one middle layer A, wherein the layers A, B and C independently of each other in each case comprise at least one thermoplastic polymer and at least one of the covering layers B and C comprises at least one polyhydroxyalkanoate. Processes for the production of the multi-layer polymer film according to the invention and its use for the production of molded parts, films or bags are furthermore presented and described.

Abstract: A multi-layer polymer film comprising at least one middle layer A, the polymeric constituents of which are soluble in aqueous solution, and in each case at least one substantially water-impermeable covering layer B, C arranged above and below the at least one middle layer A, wherein the layers A, B and C independently of each other in each case comprise at least one thermoplastic polymer and at least one of the covering layers B and C comprises at least one polyhydroxyalkanoate is presented and described. Processes for the production of the multi-layer polymer film according to the invention and its use for the production of molded parts, films or bags are furthermore presented and described.

Abstract: A process is presented and described for the production of moldings, comprising the steps of (a) providing a polymer composition comprising from 1 to 99% by weight of polyhydroxyalkanoate and from 1 to 99% by weight of starch-containing polymer; (b) homogenizing the polymer composition with use of thermal and/or mechanical energy; (c) introducing the polymer composition into a mold; (d) molding the molding in the mold; and (e) removing the molding from the mold. The process described is in particular suitable for the production of hard capsules.

Abstract: A polymer composition is presented and described and includes, based on the total weight of the polymer composition, the following components: a. from 15 to 70% by weight of PLLA, b. from 0.1 to 15% by weight of PDLA, c. from 5 to 40% by weight of polyester, and d. from 5 to 40% by weight of organic or inorganic filler. These polymer compositions can be biodegradable, comprise mainly bio-based carbon, and have an increased heat deflection temperature. These polymer compositions can moreover be used in specific processes in order to produce molded parts, films, or fibers which by virtue of their high heat deflection temperature can also be used as containers for coffee-preparation systems.

Abstract: A method for operating a drive train of a motor vehicle includes, for a starting process according to a first operating strategy, completely engaging a torque converter lockup clutch (WK) and, according to a second operating strategy, not completely engaging the torque converter lockup clutch (WK). A hydraulic pressure gradient for filling a piston chamber of the torque converter lockup clutch (WK) is selected to be higher upon selection of the first operating strategy than upon selection of the second operating strategy. A drive train module of a motor vehicle includes a control unit (5) for controlling, by way of an open-loop control system, the method.

Abstract: A method for operating a drive train of a motor vehicle includes, for a starting process according to a first operating strategy, completely engaging a torque converter lockup clutch (WK) and, according to a second operating strategy, not completely engaging the torque converter lockup clutch (WK). A hydraulic pressure gradient for filling a piston chamber of the torque converter lockup clutch (WK) is selected to be higher upon selection of the first operating strategy than upon selection of the second operating strategy. A drive train module of a motor vehicle includes a control unit (5) for controlling, by way of an open-loop control system, the method.

Abstract: A method for operating a drive train of a motor vehicle is provided, the drive train featuring a first drive assembly formed as an internal combustion engine a second drive assembly formed as an electric motor, a start-up element and a transmission). The start-up element features a converter and a lock-up clutch and is connected between the electric motor and the transmission. The electric motor is connected between the internal combustion engine and the start-up element. If a decoupling of the lock-up clutch is requested, the lock-up clutch of the start-up element is initially brought into slip. If the slip at the lock-up clutch of the start-up element reaches a threshold or is greater than the threshold, a target rotational speed is subsequently predetermined for the electric motor and the rotational speed of the electric motor is adjusted to such target rotational speed.

Abstract: A multi-layer polymer film comprising at least one middle layer A, the polymeric constituents of which are soluble in aqueous solution, and in each case at least one substantially water-impermeable covering layer B, C arranged above and below the at least one middle layer A, wherein the layers A, B and C independently of each other in each case comprise at least one thermoplastic polymer and at least one of the covering layers B and C comprises at least one polyhydroxyalkanoate is presented and described. Processes for the production of the multi-layer polymer film according to the invention and its use for the production of molded parts, films or bags are furthermore presented and described.

Abstract: The invention relates to a polymer compound which, based on the total weight of the polymer compound, comprises at least the following components: (a) 5 to 50 wgt.-% destructed starch and/or starch derivative, (b) 20 to 70 wgt.-% aliphatic-aromatic copolymer, (c) 10 to 50 wgt.-% polyhydroxyalkanoate and (d) 3 to 25 wgt.-% polyactic acid. Such polymer compounds are characterized by a high ratio of bio-based carbon and exhibit no significant embrittlement or worsening of the mechanical properties profile, despite the presence of increased volumes of polyhydroxyalkanoate, even after storage. The invention further relates to production methods for the polymer compound according to the invention, and use thereof in the production of films, molded parts or fibers.

Abstract: A process is presented and described for the production of moldings, comprising the steps of (a) providing a polymer composition comprising from 1 to 99% by weight of polyhydroxyalkanoate and from 1 to 99% by weight of starch-containing polymer; (b) homogenizing the polymer composition with use of thermal and/or mechanical energy; (c) introducing the polymer composition into a mold; (d) molding the molding in the mold; and (e) removing the molding from the mold. The process described is in particular suitable for the production of hard capsules.

Abstract: Within of the method for improving the shifting quality at the start of the commissioning of a new automatic transmission or an automated transmission of a motor vehicle, a filling pressure adaptation is carried out by individual gearshifts. At least one adaptation counter is monitored, which indicates the number of the carried out filling pressure adaptations of at least one shifting element with one individual gearshift from the commissioning of the new automatic transmission or automated transmission. As long as the value of a specified number of monitored adaptation counters falls below a specified threshold value, no D-R and R-D reversing operations are permitted by the transmission control.

Abstract: A method for operating an automatic transmission is provided. The method includes disengaging a shifting element of the automatic transmission and measuring an input speed of the automatic transmission while the shifting element is disengaging. A command pressure of the shifting element is adjusted to a target command pressure based at least in part on the input speed of the automatic transmission while the shifting element is disengaging.

Abstract: A polymer composition is presented and described and comprises, based on the total weight of the polymer composition, the following components: a. from 15 to 70% by weight of PLLA, b. from 0.1 to 15% by weight of PDLA, c. from 5 to 40% by weight of polyester, and d. from 5 to 40% by weight of organic or inorganic filler. These polymer compositions can be biodegradable, comprise mainly biobased carbon, and have an increased heat deflection temperature. These polymer compositions can moreover be used in specific processes in order to produce molded parts, films, or fibers which by virtue of their high heat deflection temperature can also be used as containers for coffee-preparation systems.

Abstract: A method for operating a drive train of a motor vehicle is provided, the drive train featuring a first drive assembly formed as an internal combustion engine a second drive assembly formed as an electric motor, a start-up element and a transmission). The start-up element features a converter and a lock-up clutch and is connected between the electric motor and the transmission. The electric motor is connected between the internal combustion engine and the start-up element. If a decoupling of the lock-up clutch is requested, the lock-up clutch of the start-up element is initially brought into slip. If the slip at the lock-up clutch of the start-up element reaches a threshold or is greater than the threshold, a target rotational speed is subsequently predetermined for the electric motor and the rotational speed of the electric motor is adjusted to such target rotational speed.

Abstract: A method for operating an automatic transmission is provided. The method includes disengaging a shifting element of the automatic transmission and measuring an input speed of the automatic transmission while the shifting element is disengaging. A command pressure of the shifting element is adjusted to a target command pressure based at least in part on the input speed of the automatic transmission while the shifting element is disengaging.