Abstract: A system for component interconnection for use in liquid chromatography includes a first switching valve and a second switching valve. A first connecting line fluidly connects the first switching valve to the second switching valve. A second connecting line fluidly connects the first switching valve to the second switching valve. A metering device is located in the first connecting line.

Abstract: Methods and systems are provided for the identification of sample cells in a sample tray that is placed in a chromatography autosampler. A cell gripper and labels are also provided to facilitate such identification.

Abstract: Methods and systems are provided for the identification of sample cells in a sample tray that is placed in a chromatography autosampler. A cell gripper and labels are also provided to facilitate such identification.

Abstract: The present invention relates to a method of loading a fluid into a fluidic element, wherein the method is performed in a fluidic system comprising the fluidic element, wherein the method comprises determining a volume that has flown into the fluidic element since a start time tstart, and at a switching time tswitch, switching the fluidic system to an operating state to stop flow into the fluidic element. The present invention also relates to a fluidic system configured for performing the method, and to a corresponding computer program product.

Abstract: A method performed in a liquid chromatography system includes a metering device pushing a sample into a trap column. The metering device sucks in the sample from a sample reservoir, wherein the sucking in the sample from a sample reservoir precedes the step of pushing the sample into the trap column. The liquid chromatography system also includes a trap column and a metering device, wherein the system is adapted to assume a configuration allowing the metering device to push a sample into the trap column and wherein the metering device is adapted to push the sample into the trap column in this configuration, wherein the system is adapted to assume a configuration allowing the sample to be sucked into the system by means of the metering device. Furthermore, the invention relates to a use of the liquid chromatography system for liquid chromatography, in particular of high-pressure liquid chromatography.

Abstract: A method for collecting a sample for sample analysis includes drawing a first portion of the sample into a sample storage portion of a chromatography system while the chromatography system is in a first configuration. The method further comprising switching the chromatography system to a second configuration; sealing an end of a sample pick-up needle and draining a portion of a liquid from the second tubing; switching the chromatography system to a third configuration; drawing a second portion of the sample into the sample storage portion of the chromatography system; switching the chromatography system to an injection configuration; and fluidly connecting the sample storage portion to the chromatography column and supplying the first portion of the sample and the second portion of the sample from the sample storage portion to the chromatography column.

Abstract: The present invention relates to a needle (1), wherein the needle (1) comprises a channel (12) extending through the needle (1), wherein the needle (1) comprises a needle tip (11), wherein the channel (12) comprises an opening at the needle tip (11), wherein the needle (1) defines an axial direction (x), wherein the axial direction (x) defines a distal direction and a proximal direction, wherein the needle tip (11) is a distal portion of the needle (1), and wherein the needle tip (11) comprises a first surface section (112) and a second surface section (111), wherein the first surface section (112) is arranged at a first angle (?) with respect to the axial direction (x) and the second surface section (111) is arranged at a second angle (?) with respect to the axial direction (x), wherein the first angle is different from the second angle. The present invention also relates to a corresponding apparatus, system and use.

Abstract: A system for component interconnection for use in liquid chromatography includes a first switching valve and a second switching valve. A first connecting line fluidly connects the first switching valve to the second switching valve. A second connecting line fluidly connects the first switching valve to the second switching valve. A metering device is located in the first connecting line.

Abstract: A system for component interconnection for use in liquid chromatography includes a first switching valve and a second switching valve. A first connecting line fluidly connects the first switching valve to the second switching valve. A second connecting line fluidly connects the first switching valve to the second switching valve. A metering device is located in the first connecting line.

Abstract: A method performed in a liquid chromatography system includes a metering device pushing a sample into a trap column. The metering device sucks in the sample from a sample reservoir, wherein the sucking in the sample from a sample reservoir precedes the step of pushing the sample into the trap column. The liquid chromatography system also includes a trap column and a metering device, wherein the system is adapted to assume a configuration allowing the metering device to push a sample into the trap column and wherein the metering device is adapted to push the sample into the trap column in this configuration, wherein the system is adapted to assume a configuration allowing the sample to be sucked into the system by means of the metering device. Furthermore, the invention relates to a use of the liquid chromatography system for liquid chromatography, in particular of high-pressure liquid chromatography.

Abstract: A method of introducing a sample into a separation column includes introducing the sample into a trap column, isolating the trap column from ambient atmosphere and pressurizing the trap column to a first pressure while the trap column is isolated from ambient atmosphere, providing a fluid connection between the trap column and the separation column after pressurizing the trap column to the first pressure, supplying the sample from the trap column to the separation column.

Abstract: A method performed in a liquid chromatography system that includes a metering device pushing a sample into a trap column. The metering device sucks in the sample from a sample reservoir, wherein the sucking in the sample from a sample reservoir precedes the step of pushing the sample into the trap column. The liquid chromatography system also includes a trap column and a metering device (100), wherein the system (1000) is adapted to assume a configuration allowing the metering device (100) to push a sample into the trap column (6) and wherein the metering device (100) is adapted to push the sample into the trap column (6) in this configuration, wherein the system (1000) is adapted to assume a configuration allowing the sample to be sucked into the system (1000) by means of the metering device (100). Furthermore, the invention relates to a use of the liquid chromatography system (1000) for liquid chromatography, in particular of high pressure liquid chromatography.

Abstract: A method of introducing a sample into a separation column includes introducing the sample into a trap column, isolating the trap column from ambient atmosphere and pressurizing the trap column to a first pressure while the trap column is isolated from ambient atmosphere, providing a fluid connection between the trap column and the separation column after pressurizing the trap column to the first pressure, supplying the sample from the trap column to the separation column.

Abstract: The present invention relates to a method for collecting a sample for sample analysis. The method comprises a system assuming a first configuration and drawing a first portion of the sample into a sample storage portion of the system in the first configuration; the system assuming a second configuration, which is different from the first configuration, and preparing the system in the second configuration to draw a second portion of the sample into the sample storage portion; the system assuming a third configuration and drawing the second portion of the sample into the sample storage portion in the third configuration; and the system assuming an injection configuration, wherein the sample storage portion is fluidly connected to a chromatography column, and supplying the first portion of the sample and the second portion of the sample from the sample storage portion to the chromatography column, while the system is in the injection configuration.

Abstract: A liquid chromatography system includes a separation column, a trap column, and a first switching valve. The first switching valve is adapted to assume a first switching position for bringing a sample into the trap column in a first flow direction. The switching valve is also adapted to assume a second switching position for fluidly connecting the trap column with the separation column and providing a flow from the trap column to the separation column in a second flow direction. The second flow direction is opposite to the first flow direction. The first switching valve is adapted to assume a third switching position for fluidly connecting the trap column, with the separation column and providing a flow from the trap column to the separation column in the first flow direction.

Abstract: A method of introducing a sample into a separation column includes introducing the sample into a trap column, isolating the trap column from ambient atmosphere and pressurizing the trap column to a first pressure while the trap column is isolated from ambient atmosphere, providing a fluid connection between the trap column and the separation column after pressurizing the trap column to the first pressure, supplying the sample from the trap column to the separation column.

Abstract: A system for component interconnection for use in liquid chromatography includes a first switching valve and a second switching valve. A first connecting line fluidly connects the first switching valve to the second switching valve. A second connecting line fluidly connects the first switching valve to the second switching valve. A metering device is located in the first connecting line.

Abstract: A liquid chromatography system includes a separation column, a trap column, and a first switching valve. The first switching valve is adapted to assume a first switching position for bringing a sample into the trap column in a first flow direction. The switching valve is also adapted to assume a second switching position for fluidly connecting the trap column with the separation column and providing a flow from the trap column to the separation column in a second flow direction. The second flow direction is opposite to the first flow direction. The first switching valve is adapted to assume a third switching position for fluidly connecting the trap column, with the separation column and providing a flow from the trap column to the separation column in the first flow direction.

Abstract: A method performed in a liquid chromatography system that includes a metering device pushing a sample into a trap column. The metering device sucks in the sample from a sample reservoir, wherein the sucking in the sample from a sample reservoir precedes the step of pushing the sample into the trap column. The liquid chromatography system also includes a trap column and a metering device (100), wherein the system (1000) is adapted to assume a configuration allowing the metering device (100) to push a sample into the trap column (6) and wherein the metering device (100) is adapted to push the sample into the trap column (6) in this configuration, wherein the system (1000) is adapted to assume a configuration allowing the sample to be sucked into the system (1000) by means of the metering device (100). Furthermore, the invention relates to a use of the liquid chromatography system (1000) for liquid chromatography, in particular of high pressure liquid chromatography.