Abstract: The invention relates to methods for synthesizing amanitin derivatives having an amino group attached to position 6? of the central tryptophan moiety. The invention furthermore relates to an amanitin derivative having an amino group attached to position 6? of the central tryptophan moiety, conjugates of such amanitin derivative, and pharmaceutical compositions comprising such conjugates.

Abstract: A battery system for an electrically drivable vehicle includes at least one set of battery electronics that delivers a battery voltage, and at least one rechargeable traction battery connected to an input of the set of battery electronics, the traction battery configured for connection to at least one supplementary traction battery connectable in series or parallel to enable the traction battery capacity and/or life to be extended. The battery system may include a traction battery housing having a main compartment configured to receive the traction battery and at least one supplemental compartment configured to receive a modular supplemental traction battery.

Abstract: A medical instrument for endoscopic removal of the saphenous vein has an elongated shaft which hat at the distal end a spatula tip and in whose proximal region is arranged a laterally projecting handle. The instrument further has an endoscopic optical system which has an eyepiece cup that is arranged at the proximal end of the instrument. The handle is joined to the shaft in such a way that an outer side of the instrument facing away from the handle continuously has a surface that, from the distal to the proximal end, is free of projections. The eyepiece cup is arranged in oblique orientation with respect to a longitudinal center axis of the shaft and encloses with the handle, with respect to the longitudinal center axis, an angle of less than 90°.

Abstract: A medical instrument for endoscopic removal of the saphenous vein has an elongated shaft which hat at the distal end a spatula tip and in whose proximal region is arranged a laterally projecting handle. The instrument further has an endoscopic optical system which has an eyepiece cup that is arranged at the proximal end of the instrument. The handle is joined to the shaft in such a way that an outer side of the instrument facing away from the handle continuously has a surface that, from the distal to the proximal end, is free of projections. The eyepiece cup is arranged in oblique orientation with respect to a longitudinal center axis of the shaft and encloses with the handle, with respect to the longitudinal center axis, an angle of less than 90°.

Abstract: A medical instrument for endoscopic removal of the saphenous vein has an elongated shaft which has at the distal end a spatula tip and in whose proximal region is arranged a laterally projecting handle. The instrument further has an endoscopic optical system which has an eyepiece cup that is arranged at the proximal end of the instrument. The handle is joined to the shaft in such a way that an outer side of the instrument facing away from the handle continuously has a surface that, from the distal to the proximal end, is free of projections. The eyepiece cup is arranged in oblique orientation with respect to a longitudinal center axis of the shaft and encloses with the handle, with respect to the longitudinal center axis, an angle of less than 90°.

Abstract: A protective assembly for the head which has a circular support structure adapted to be connected to the head of the person wearing the protective assembly. A protective visor is pivotally connected to the support structure to be swiveling from a lower operating position to an upper resting position. Mechanisms, having actuating members, are provided for adjusting and fixing the position of the visor in the viewing direction and in the lower operating position. All of the actuating members are located at the outer side of the protective assembly and the visor respectively, such that they can be activated while the protective assembly is being worn.