Patents by Inventor Christoph Muus

Christoph Muus has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Lineage tracing using mitochondrial genome mutations and single cell genomics
    Patent number: 12012633
    Abstract: Embodiments disclosed herein provide methods of using somatic mutations in mitochondrial genomes to retrospectively infer cell lineages in native contexts and to serve as genetic barcodes to measure clonal dynamics in complex cellular populations. Further, somatic mutations in mitochondrial DNA (mtDNA) are tracked by single cell genomic approaches for simultaneous analysis of single cell lineage and state. Applicants further show that mitochondrial mutations can be readily detected with contemporary single cell transcriptomic and epigenomic technologies to concomitantly capture gene expression profiles and chromatin accessibility, respectively.
    Type: Grant
    Filed: June 11, 2019
    Date of Patent: June 18, 2024
    Assignees: The Broad Institute, Inc., Massachusetts Institute of Technology, The Children's Medical Center Corporation, President and Fellows of Harvard College
    Inventors: Leif S. Ludwig, Caleb A. Lareau, Jacob C. Ulirsch, Aviv Regev, Vijay G. Sankaran, Jason Buenrostro, Christoph Muus
  • LINEAGE TRACING USING MITOCHONDRIAL GENOME MUTATIONS AND SINGLE CELL GENOMICS
    Publication number: 20210246503
    Abstract: Embodiments disclosed herein provide methods of using somatic mutations in mitochondrial genomes to retrospectively infer cell lineages in native contexts and to serve as genetic barcodes to measure clonal dynamics in complex cellular populations. Further, somatic mutations in mitochondrial DNA (mtDNA) are tracked by single cell genomic approaches for simultaneous analysis of single cell lineage and state. Applicants further show that mitochondrial mutations can be readily detected with contemporary single cell transcriptomic and epigenomic technologies to concomitantly capture gene expression profiles and chromatin accessibility, respectively.
    Type: Application
    Filed: June 11, 2019
    Publication date: August 12, 2021
    Inventors: Leif S. Ludwig, Caleb A. Lareau, Jacob C. Ulirsch, Aviv Regev, Vijay G. Sankaran, Jason Buenrostro, Christoph Muus