Abstract: The present invention relates to specific binding members, particularly antibodies and fragments thereof, which bind to amplified epidermal growth factor receptor (EGFR) and to the de2-7 EGFR truncation of the EGFR. In particular, the epitope recognized by the specific binding members, particularly antibodies and fragments thereof, is enhanced or evident upon aberrant post-translational modification. These specific binding members are useful in the diagnosis and treatment of cancer. The binding members of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof.

Abstract: The invention relates to MHC-Ia open conformers as immunomodulatory agents, particularly in the treatment or prevention of cancer. The open conformer comprises or consists of a first and a second monomer, and each monomer comprises a HLA-heavy chain from the MHC-Ia molecules. The open conformer further comprises a protein stabilizing polypeptide sequence and optionally an amino acid linker. Further aspects of the invention provide combination medicaments comprising the MHC-Ia open conformers and immune checkpoint inhibitors. Furthermore, the invention relates to the use of MHC-Ia open conformers as immunomodulators, particularly in diseases where the interaction to diverse immunoregulatory receptors such as KIR3DL1, KIR3DL2, KIR3DL3, LILRB1, LILRB2, and PTPRJ modulates an immune response, and in diseases were the negative modulation of Tregs is a therapeutic strategy, e.g. infectious diseases.

Abstract: The invention relates to a protecting member for a battery structure of an electric vehicle. The protecting member includes a top belt, a bottom belt and a core arranged between and interconnecting the top belt and the bottom belt. The core is at least partially made from a porous and fibrous structural material, such as plywood.

Abstract: A wheel includes a rim and a wheel center interconnected to the rim. The wheel center includes at least one spoke extending from a wheel hub to the rim in a radial direction. The rim includes per the at least one spoke a first contact area and the at least one spoke includes at its outer end a second contact area which in a mounted position is aligned to the first contact area. The at least one spoke includes at least one hollow space extending in the radial direction of the spoke.

Abstract: A wheel (1) includes a rim (2) and a wheel center (3) made from a fiber reinforced composite material. The wheel center (3) includes a tubular middle section (6) having a center opening (7) extending in the direction of a wheel axis (19) and having a first and a second end (8, 9). A hub (5) includes a first flange ring (10) and a second flange ring (11). At least one of the flange rings (10, 11) and the tubular middle section (6) are interconnected to each other by a form fit interconnection (12, 13).

Abstract: The invention relates to a HLA-B27 Fc open conformer or a HLA-B27 Fc fusion protein for use in the treatment or prevention of cancer. The Fc open conformer comprises or consists of a first and a second monomer, and each monomer comprises a HLA-B27 chain. The Fc fusion protein further comprises a protein stabilizing polypeptide sequence and optionally an amino acid linker. Further aspects of the invention provide combination medicaments comprising the HLA-B27 Fc open conformer and immune checkpoint inhibitors.

Abstract: The invention relates to a HLA-B57 open conformer or a HLA-B57 Fc fusion protein for use in the treatment or prevention of cancer. The Fc open conformer comprises or consists of a first and a second monomer, and each monomer comprises a HLA-B57 chain. The Fc fusion protein further comprises a protein stabilizing polypeptide sequence and optionally an amino acid linker. Further aspects of the invention provide combination medicaments comprising the HLA-B57 Fc open conformer and immune checkpoint inhibitors and/or checkpoint agonist agents. Furthermore, the invention relates to the use of HLA-B57 open conformer as an immunomodulator, particularly in diseases where modulation of diverse immune cell components (e.g. cytotoxic CD8+T cells, Tregs) is a therapeutic strategy, e.g. infectious diseases.

Abstract: Wheel comprising a rim and a wheel center wherein the wheel center comprises several spokes extending in a longitudinal direction from a wheel hub to the rim. At least one spoke comprises an outer wall surrounding a cavity extending in the longitudinal direction of the at least one spoke. The cavity is delimited from the outer wall by an inner surface. The at least one spoke further comprises a reinforcing member extending along the inner surface.

Abstract: The invention relates to a HLA-B57 open conformer or a HLA-B57 Fc fusion protein for use in the treatment or prevention of cancer. The Fc open conformer comprises or consists of a first and a second monomer, and each monomer comprises a HLA-B57 chain. The Fc fusion protein further comprises a protein stabilizing polypeptide sequence and optionally an amino acid linker. Further aspects of the invention provide combination medicaments comprising the HLA-B57 Fc open conformer and immune checkpoint inhibitors and/or checkpoint agonist agents. Furthermore, the invention relates to the use of HLA-B57 open conformer as an immunomodulator, particularly in diseases where modulation of diverse immune cell components (e.g. cytotoxic CD8+ T cells, Tregs) is a therapeutic strategy, e.g. infectious diseases.

Abstract: The invention relates to MHC-Ia open conformers as immunomodulatory agents, particularly in the treatment or prevention of cancer. The open conformer comprises or consists of a first and a second monomer, and each monomer comprises a HLA-heavy chain from the MHC-Ia molecules. The open conformer further comprises a protein stabilizing polypeptide sequence and optionally an amino acid linker. Further aspects of the invention provide combination medicaments comprising the MHC-Ia open conformers and immune checkpoint inhibitors. Furthermore, the invention relates to the use of MHC-Ia open conformers as immunomodulators, particularly in diseases where the interaction to diverse immunoregulatory receptors such as KIR3DL1, KIR3DL2, KIR3DL3, LILRB1, LILRB2, and PTPRJ modulates an immune response, and in diseases were the negative modulation of Tregs is a therapeutic strategy, e.g. infectious diseases.

Abstract: A wheel (1) for a vehicle and a related method for manufacturing the wheel includes a rim (2) and a wheel center (3). The wheel center includes several spokes (4) extending from a hub (5), with a center opening (6), radially outwards to the rim (2). The hub (5) is made from a fiber-reinforced plastic material and is covered on the outboard side from a three-dimensionally shaped support cover (7) made from metallic material.

Abstract: The invention relates to MHC-Ia open conformers as immunomodulatory agents, particularly in the treatment or prevention of cancer. The open conformer comprises or consists of a first and a second monomer, and each monomer comprises a HLA-heavy chain from the MHC-Ia molecules. The open conformer further comprises a protein stabilizing polypeptide sequence and optionally an amino acid linker. Further aspects of the invention provide combination medicaments comprising the MHC-Ia open conformers and immune checkpoint inhibitors. Furthermore, the invention relates to the use of MHC-Ia open conformers as immunomodulators, particularly in diseases where the interaction to diverse immunoregulatory receptors such as KIR3DL1, KIR3DL2, KIR3DL3, LILRB1, LILRB2, and PTPRJ modulates an immune response, and in diseases were the negative modulation of Tregs is a therapeutic strategy, e.g. infectious diseases.

Abstract: A wheel includes a rim that is at least partially made from a fiber reinforced plastic. The rim has an inner side extending to the hub region of the wheel and an outer side extending centrifugally away from the hub region of the wheel whereby the outer side includes a well which is interconnected with an outer shoulder by a transition area. A wheel center is interconnected with the inner side of the rim by at least one fastener wherein the at least one fastener penetrates the rim via at least one opening that extends from the inner side of the rim to the outer side of the rim. An annular cover is arranged at the outer side of the rim in a circumferential direction around the wheel and thereby covers the at least one fastener and/or the at least one opening.

Abstract: The present invention relates to specific binding members, particularly antibodies and fragments thereof, which bind to amplified epidermal growth factor receptor (EGFR) and to the de2-7 EGFR truncation of the EGFR. In particular, the epitope recognized by the specific binding members, particularly antibodies and fragments thereof, is enhanced or evident upon aberrant post-translational modification. These specific binding members are useful in the diagnosis and treatment of cancer. The binding members of the present invention may also be used in therapy in combination with chemotherapeutics or anti-cancer agents and/or with other antibodies or fragments thereof.

Abstract: Methods, systems, and media for identifying abusive content items are provided.

Abstract: The invention is directed to a method for producing a rim (2) comprising at least one three-dimensionally shaped layer of reinforcing fibers (26). In a first step a forming tool (25) is provided which comprises a three-dimensionally shaped outer contour. In a subsequent step a band of reinforcing fibers (26) is wound onto the forming tool (25) such that the reinforcing fibers follow the outer contour of the forming tool (25) and are arranged in at least one of reinforcing fibers. A draping device (27) is provided by which the band of reinforcing fibers (26) is preformed before the band of reinforcing fibers (26) is wound onto the forming tool (25).

Abstract: Wheel comprising a rim and a wheel center wherein the wheel center comprises several spokes extending in a longitudinal direction from a wheel hub to the rim. At least one spoke comprises an outer wall surrounding a cavity extending in the longitudinal direction of the at least one spoke. The cavity is delimited from the outer wall by an inner surface. The at least one spoke further comprises a reinforcing member extending along the inner surface.

Abstract: A wheel includes a rim and a wheel center with several spokes with at least one butt strap. The at least one butt strap protrudes from a radially outer end of the spokes. The rim includes at least one opening arranged corresponding to the at least one butt strap. The at least one butt strap extends across the related opening in the rim and is attached to the outside of the rim.

Abstract: The invention is directed to a heat shield structure (8) for a wheel (1) which comprises a base structure (11) that is at least partially made from a composite material. The heat shield structure (8) is arranged on the base structure (11) and is at least partially covering the base structure (11).

Abstract: A wheel (1) includes a rim (2) and a wheel center (3) made from a fiber reinforced composite material. The wheel center (3) includes a tubular middle section (6) having a center opening (7) extending in the direction of a wheel axis (19) and having a first and a second end (8, 9). A hub (5) includes a first flange ring (10) and a second flange ring (11). At least one of the flange rings (10, 11) and the tubular middle section (6) are interconnected to each other by a form fit interconnection (12, 13).