Abstract: The present disclosure relates to a multi-layer oral thin film comprising a first and a second matrix layer, which each contain at least one polymer, and a separation layer located between the first and the second matrix layer, wherein the separation layer comprises at least one polyethylene glycol, to a method for production of the oral thin film, and to the use thereof as a medicament.

Abstract: Gear arrangement for a vehicle, having an input shaft, a layshaft, an output shaft connected to a drive wheel of the vehicle, a plurality of shiftable first gear wheel sets which connect the input shaft and the layshaft and which are each associated with at least one gear stage, and a machine gear connected to one of the shafts and into which the drive torque of an electric machine can be introduced. The first gear wheel sets form a first part-gear mechanism, wherein at least one second shiftable gear wheel set connects the layshaft and the output shaft and forms a second part-gear mechanism, wherein the at least one second gear wheel set is associated with at least one gear stage and wherein the machine gear is arranged in an axial direction between the first part-gear mechanism and the second part-gear mechanism.

Abstract: The present invention relates to a multi-layer thin film comprising at least two layers arranged one on top of the other which each comprise at least one polymer, these at least two layers being connected to one another by at least one stitched seam using at least one thread, and to a method for producing such a thin film and to the use thereof as a medicament.

Abstract: The present invention relates to an oral thin film comprising a polymer matrix in the form of a solidified foam having voids, wherein the polymer matrix contains at least one active pharmaceutical ingredient, at least one first polymer which comprises a water-soluble polymer and at least one second polymer which comprises a mucoadhesive polymer having a number-average molecular weight of equal to or greater than 100,000 g/mol, a method for producing the oral thin film, and the use of such an oral thin film as a medicament.

Abstract: The present invention is an equipment and a process for the handling of fibrous webs that comprise particulate additives, which are positioned within interstices between the fibers and/or on the surface of the webs. By applying the present invention, predetermined regions are created in the web, which are essentially free of the particulate additives.

Abstract: The present invention relates to frigostable compositions suitable for iontophoretic transdermal delivery of a triptan compound. The inventive compositions include a salt of a triptan compound, preferably sumatriptan succinate, a polyamine, a dicarboxylic acid, and water or an aqueous solvent mixture, with the composition being free of monocarboxylic acids. The invention further relates to the use of the composition as an integral component of an iontophoretic patch, preferably as an anodic reservoir of the patch.

Abstract: The present invention relates to iontophoretic compositions comprising a ketamine salt, a thickener in an amount to provide a viscosity of at least 500 mPas (at 20° C.), and water, and to their use for treating pain or depression. The present invention further relates to kits that comprise corresponding iontophoretic compositions and an iontophoresis device.

Abstract: The invention relates to a transdermal therapeutic system for the controlled release of water-soluble pharmaceutical active ingredients from an aqueous phase, comprising an occlusive back layer, a central device facing the skin for releasing the agent, an adhesive layer concentrically surrounding the dispensing device and a removable protective film. Said device is made from a stationary solid phase and a liquid phase containing the active ingredient in aqueous solution, the solid phase being formed from a solid with a fleecy or spongy structure.

Abstract: The present invention relates to the field of hygiene appliances, in particular to hygiene articles comprising a means for reducing soiling of the skin of a wearer by body exudates such as faeces, urine, or menses. In particular, it relates to an article with a Skin Protection Sheet (SPS) that comprises a rear opening in registry with the anus during use, and a front opening in registry with a body exudate releasing body opening or genital organ. The openings are urged to the body by a pull means, whilst being spread open cross-directionally, allowing exudates to pass through. Such a hygiene article may suitably be a baby or adult diaper or pant, a training pant, or a menstrual pant.

Abstract: The present invention relates to frigostable compositions suitable for iontophoretic transdermal delivery of a triptan compound that includes: a salt of a triptan compound, preferably sumatriptan succinate, a polyamine, one or more dicarboxylic acids, 0.5 to 10.0 wt.-% (based on the total weight of the composition) of one or more monocarboxylic acids, and water or an aqueous solvent mixture. The invention further relates to the use of the composition as an integral component of an iontophoretic patch, preferably as an anodic reservoir of the patch.

Abstract: The present invention is a roll as may function as an anvil roll that comprises protrusions on its outer surface, that are outwardly or z-directionally oriented arcs of an arc wire such as wavy wire or an axially canted helical coil extending along a length or x-direction, which are pinched perpendicularly to the z- and x-direction. Such anvil rolls may be used to treat materials such as web materials, such as by embossing or bonding these web materials. In a particular application, such rolls may interact with an ultrasonic sonotrode.

Abstract: The invention relates to a transdermal therapeutic system (TTS) for delivering pharmaceutical active ingredients. The TTS includes a cover layer and at least one active-ingredient-containing carrier material. At least one retaining element is located between the active-ingredient-containing carrier material and the cover layer, with the retaining element fixing the active-ingredient-containing carrier material onto the cover layer. The invention further relates to a method for fastening an active-ingredient-containing carrier material to a cover layer of a TTS in the presence of hook-and-loop strip segments and the use of a hook-and-loop strip in transdermal or iontophoretic administration of pharmaceutical or therapeutic active ingredients to patients.

Abstract: The present invention additionally relates to a dosage form for an active substance, selected from the group of cannabinoids, for dissolving in the oral cavity, comprising a first film layer and a second film layer, arranged over the first film layer, wherein the composition of the first film layer can be identical to that of the second film layer and comprises a water soluble polymer, the first and second film layer being connected to each other via the overlapping edges thereof, forming at least one cavity, and the cavity being filled with an active substance selected from the group of cannabinoids.

Abstract: The invention relates to film-like forms of administration for the transmucosal delivery of antidiabetic peptides via the oral mucosa and to processes for the production thereof. Antidiabetic peptides refers to peptides which are an active compound for the treatment of diabetes mellitus, and includes insulins, insulin analogs, incretins and incretin mimetics.

Abstract: The present invention relates to the field of hygiene appliances, in particular to a means for reducing soiling of the skin of a wearer upon defecation. In particular, it relates to a hygiene article comprising a skin protection sheet that comprises a discontinuity as a faeces passageway, such as an opening or a slit. In use, the sheet and the discontinuity are urged towards the anus by a pull means and spread open by a spreading means, such that faeces can pass through the discontinuity but are separated from the skin of the wearer elsewhere.

Abstract: The present invention relates to an oral thin film comprising at least one polymer and at least one pharmaceutically active ingredient, the oral thin film being substantially U-shaped, and to the use of said oral thin film as a medicament, especially for sub-lingual administration.

Abstract: The present invention relates to transdermal therapeutic systems (TTS) for the transdermal administration of nicotine comprising a nicotine-containing layer structure, said nicotine-containing layer structure comprising A) a backing layer and B) a nicotine-containing layer, wherein the transdermal therapeutic system comprises a silicone acrylic hybrid polymer.

Abstract: The present invention relates to transdermal therapeutic systems (TTS) for the transdermal administration of an active agent comprising an active agent-containing layer structure, said active agent-containing layer structure comprising A) a backing layer, B) an active agent-containing layer comprising a therapeutically effective amount of the active agent, and C) a skin contact layer comprising at least one silicone acrylic hybrid polymer.

Abstract: Described are: a multi-layer oral thin film, comprising at least two layers arranged one on top of the other, which each comprise at least one water-soluble polymer, these at least two layers being connected to one another by at least one sealing, characterised in that the at least one sealing is not provided over the entire surface; a method for producing same; and use thereof as a medicament.