Abstract: This invention relates to novel phenyl amide or pyridyl amide derivatives of the formula wherein A1, A2, B1, B2 and R1 to R11 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are GPBAR1 agonists and can be used as medicaments for the treatment of diseases such as type II diabetes.

Abstract: This invention relates to novel phenyl amide or pyridyl amide derivatives of the formula wherein A1, A2, B1, B2 and R1 to R11 are as defined in the description and in the claims, as well as pharmaceutically acceptable salts thereof. These compounds are GPBAR1 agonists and can be used as medicaments for the treatment of diseases such as type II diabetes.

Abstract: A device (10) for removing a tattoo comprises a tattoo machine tip (14) and a tattoo machine (12). The tattoo machine tip (12) comprises a tip body (28) that comprises a needle channel (32) for guiding at least one tattooing needle (34). Said tip body (28) is connected with a supply container (50) for receiving a liquid. According to the invention, said supply container (50) is filled with a skin irritant (52). Further, said supply container (50) is connected through a feed channel for wetting the tattooing needle (34) with said skin irritant (52) with said needle channel (32), wherein said feed channel (54) opens out into said needle channel (32). Unnecessary dead volumes are avoided thereby, so that the consumption of skin irritant is minimized.

Abstract: An apparatus according to the invention comprises a needle roll (1) and a perforated roll (2), between which a sheet-like structure (3) can be perforated and deformed. The needle roll (1) has a large number of needles (11), while the perforated roll (2) is provided with a large number of holes (21) to accommodate needles (11) of the needle roll (1). The needle roll (1) and the perforated roll (2) are formed and arranged such that during the perforating and deforming operations, each needle (11) in the perforating and deforming area penetrates into a hole (21) in the perforated roll (2). In this way, the sheet-like structure (3) located between them is not only perforated, but the edges of the holes in the sheet-like structure (3) are also shaped three-dimensionally in a controlled way between the needles (11) and the edges of the holes in the perforated roll (2).