Abstract: The present invention relates to novel compounds of the formula I, methods for their preparation and their use for treatment of diseases. The invention discloses the synthesis of levodopa (L-DOPA) esters by coupling polyhydroxy compounds or their derivatives to the L-DOPA carboxyl group. The synthesis allows to produce L-DOPA derivatives which are highly soluble in water as well as aqueous and biocompatible liquids and have an improved hydrolytic stability in water or aqueous and biocompatible media for an application over several days. The invention helps producing L-DOPA substances for applications in the fields of medicine, biology and medical engineering as well as in the pharmaceutical industry.

Abstract: The present invention describes a new method and new combination products for the therapy of neurological and other conditions which respond to dopaminergic therapies and especially to L-DOPA (L-Dihydroxy-Phenylalanine) based on the use of L-DOPA esters, especially of L-DOPA glycerol ester and L-DOPA Cholin Ester.

Abstract: The present invention relates to novel compounds of the formula I, methods for their preparation and their use for treatment of diseases. The invention discloses the synthesis of levodopa (L-DOPA) esters by coupling polyhydroxy compounds or their derivatives to the L-DOPA carboxyl group. The synthesis allows to produce L-DOPA derivatives which are highly soluble in water as well as aqueous and biocompatible liquids and have an improved hydrolytic stability in water or aqueous and biocompatible media for an application over several days. The invention helps producing L-DOPA substances for applications in the fields of medicine, biology and medical engineering as well as in the pharmaceutical industry.

Abstract: An electromechanical brake booster for a brake system of a vehicle includes: a booster housing; and a valve element, which is situated in a continuous receiving opening of the booster housing in a manner that allows an adjustment in relation to the booster housing, and which has a continuous central opening within which a valve piston is positioned or able to be positioned in a manner that allows an adjustment in relation to the valve element such that a driver-applied brake force is transmittable via an input rod to an output rod. In addition, a ball segment is situated or developed on the valve element, which contacts a conical seat of a disk of the electromechanical brake booster situated between the ball segment and the booster housing so as to allow an adjustment in relation to the booster housing.

Abstract: An electromechanical brake booster for a brake system of a vehicle includes: a booster housing; and a valve element, which is situated in a continuous receiving opening of the booster housing in a manner that allows an adjustment in relation to the booster housing, and which has a continuous central opening within which a valve piston is positioned or able to be positioned in a manner that allows an adjustment in relation to the valve element such that a driver-applied brake force is transmittable via an input rod to an output rod. In addition, a ball segment is situated or developed on the valve element, which contacts a conical seat of a disk of the electromechanical brake booster situated between the ball segment and the booster housing so as to allow an adjustment in relation to the booster housing.

Abstract: A biodegradable, injectable oligomer-polymer composition is described, which consists of a combination of at least two biologically degradable inert materials and at least one biologically active ingredient. The inventive, oligomer-polymer composition coagulates when injected into the body of a mammal and forms an implant, from which the biologically active ingredient is released. The rate of release can be adjusted by controlling the type and amount of the ingredients of the oligomer-polymer composition.

Abstract: This invention relates to an in-situ implant that can be produced by placing a sterile, injectable, and water-insoluble complex from a biodegradable polymer and a biocompatible polyether with functional end-groups in the organism, and coagulating them under the influence of the body fluid. This coagulate may optionally contain at least one bioactive substance selected from the group of hormones, immunomodulators, immunosuppressants, antibiotics, cytostatics, diuretics, gastro-intestinal agents, analgesics, local anaesthetics and/or neuropharmacological agents.

Abstract: The invention relates to a transdermal therapeutic system for application to the skin and/or mucosa consisting of at least one active substance in the form of a solid dispersion in combination with at least one destructuring agent and/or at least one structuring agent in a common matrix.