Abstract: Disclosed herein is a vaccine composition for raising a humoral response to PD1, and uses thereof, for treating a cancer characterised by an involvement of PD1, wherein the vaccine composition comprises an effective amount of an immunogen that induces an antibody response in which the antibody binds to a B cell epitope of PD1.

Abstract: The present invention relates to a vaccine against cancerous diseases associated with the carcinoembryonic antigen CEA.

Abstract: The present invention relates to a multi-peptide-multiepitop-vaccine against cancerous diseases associated with HER-2/neu oncogene, i.e. the vaccine comprises a specific combination of peptides presenting different amino acids sequences as occur in the extracellular domain of HER-2/neu protein.

Abstract: The present invention relates to peptides of the extracellular domain of a HER-2/neu protein, conjugates comprising said peptides linked to an immunogenic carrier, compositions thereof, nucleic acid molecules, vectors and transformed or transfected host cells comprising said nucleic acid molecules encoding said peptides or conjugates, and methods for producing the disclosed peptides, conjugates and compositions. The present invention also relates to diagnostic methods of detecting cancerous conditions associated with HER-2/neu or monitoring the effectiveness of treatment against cancerous conditions associated with HER-2/neu. The present invention also relates to methods of eliciting or enhancing an immune response to HER-2/neu in a subject in need thereof.

Abstract: The present invention relates to a vaccine against cancerous diseases and antigen mimotopes associated with the high molecular weight melanoma associated antigen (HMW-MAA). The vaccines and antigen mimotopes are recognized immunologically by the monoclonal HMW-MAA antibody 225.28S and comprise at least one peptide with a length of 6 to 14 amino acids. The inventive vaccine permits active immunization against cancerous diseases associated with the high molecular weight melanoma associated antigen (HMW-MAA), whereby both prophylactic and therapeutic effects can be achieved. Further, the antigen mimotopes can serve to detect the immune response obtained.

Abstract: The present invention provides a method for producing a vaccine against cancerous disease, and the vaccine itself. This method involves first using one or more antibodies that are specifically effective against one or more antigens specially expressed by the tumor cells to select one or more mimotopes of said antigens from a phage peptide library. To obtain the vaccine, said mimotopes are conjugated to a macromolecular carrier singly or multiply in the form of their mono-, di-, tri- or oligomers. When administered, the inventively produced vaccine leads to a humoral immune response and thus to the formation of an active immunity as a consequence of vaccination.

Abstract: The present invention relates to a vaccine against cancerous diseases and antigen mimotopes associated with the high molecular weight melanoma associated antigen (HMW-MAA). The vaccines and antigen mimotopes are recognized immunologically by the monoclonal HMW-MAA antibody 225.28S and comprise at least one peptide with a length of 6 to 14 amino acids. The inventive vaccine permits active immunization against cancerous diseases associated with the high molecular weight melanoma associated antigen (HMW-MAA), whereby both prophylactic and therapeutic effects can be achieved. Further, the antigen mimotopes can serve to detect the immune response obtained.

Abstract: The present invention provides a method for producing a vaccine against cancerous disease, and the vaccine itself. This method involves first using one or more antibodies that are specifically effective against one or more antigens specially expressed by the tumor cells to select one or more mimotopes of said antigens from a phage peptide library. To obtain the vaccine, said mimotopes are conjugated to a macromolecular carrier singly or multiply in the form of their mono-, di-, tri- or oligomers. When administered, the inventively produced vaccine leads to a humoral immune response and thus to the formation of an active immunity as a consequence of vaccination.

Abstract: The present invention relates to peptides of the extracellular domain of a HER-2/neu protein, conjugates comprising said peptides linked to an immunogenic carrier, compositions thereof, nucleic acid molecules, vectors and transformed or transfected host cells comprising said nucleic acid molecules encoding said peptides or conjugates, and methods for producing the disclosed peptides, conjugates and compositions. The present invention also relates to diagnostic methods of detecting cancerous conditions associated with HER-2/neu or monitoring the effectiveness of treatment against cancerous conditions associated with HER-2/neu. The present invention also relates to methods of eliciting or enhancing an immune response to HER-2/neu in a subject in need thereof.