Patents by Inventor Christophe A. Marquette
Christophe A. Marquette has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11884001Abstract: The invention relates to an additive manufacturing method for producing a three-dimensional elastomer silicone article. The elastomer silicone article is built up layer by layer by printing a silicone composition crosslinkable by addition reactions comprising at least one organopolysiloxane-polyoxyalkylene copolymer with a 3D printer selected from an extrusion 3D printer or a material jetting 3D printer.Type: GrantFiled: May 9, 2018Date of Patent: January 30, 2024Inventors: Jean-Marc Frances, David Mariot, Christophe Marquette, Edwin-Joffrey Courtial, Rene Fulchiron, Clement Perrinet
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Publication number: 20230364306Abstract: Three-dimensional body implants including a hydrogel, which includes cross-linked alginate and gelatin, and in particular breast implants. The hydrogel of the implants has a mechanical strength of 1 kPa to 1000 kPa, and the hydrogel of the implants may further include fibrinogen. The implants include a porous zone, and the implants are acellular, i.e., free of cells during their manufacture.Type: ApplicationFiled: June 24, 2022Publication date: November 16, 2023Applicants: UNIVERSITE CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), ECOLE CENTRALE DE NANTES, ECOLE SUP CHIMIE PHYS ELECTRONIQ LYON, HEALSHAPEInventors: Christophe MARQUETTE, Audrey CHERBLANC, Morgan DOS SANTOS, Luciano VIDAL, Emma PETIOT, Laura CHASTAGNIER, Amélie THEPOT, Baptiste GODET
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Publication number: 20230323305Abstract: A bioink comprises a cell solution comprising living cells and a cell culture medium, and a self-assembling peptide solution comprising a self-assembling peptide. The bioink is formed by mixing and extruding the cell solution and the self-assembling peptide solution together, and the bioink can be continuously extruded from the mixer after mixing. Useful methods of making bioinks and are also disclosed.Type: ApplicationFiled: April 5, 2023Publication date: October 12, 2023Applicants: 3-D Matrix, Ltd., CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE CLAUDE BERNARD LYON 1 (UCBL1), L’ECOLE SUPERIEURE DE CHIMIE, PHYSIQUE, ELECTRONIQUE DE LYON (CPE Lyon)Inventors: Christophe A. Marquette, Marie Reveiller Buffier, Marika G. Rioult, Eun Seok Gil
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Publication number: 20230323306Abstract: A jammed gel bioink comprises a self-assembling peptide solution comprising a self-assembling peptide, and a cell solution comprising living cells and a cell culture medium. The self-assembling peptide solution is extruded to form an object, and then the cell solution is injected into the object. Useful methods of making the jammed gel bioink are also disclosed.Type: ApplicationFiled: April 5, 2023Publication date: October 12, 2023Applicants: 3-D Matrix, Ltd., CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), UNIVERSITE CLAUDE BERNARD LYON 1 (UCBL1), L’ECOLE SUPERIEURE DE CHIMIE, PHYSIQUE, ELECTRONIQUE DE LYON (CPE Lyon)Inventors: Christophe A. Marquette, Marie Reveiller Buffier, Marika G. Rioult, Eun Seok Gil
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Publication number: 20230202095Abstract: Methods for additive manufacturing include depositing a printing material in suspension within a printing tray containing a stressed medium, to form a three-dimensional object. This deposition of printing material is performed via at least one step of injecting the printing material using a nozzle of a printing head, which nozzle is immersed in the stressed medium and is able to move within the stressed medium in the three dimensions in space. This method comprises at least a step of modifying the level of the stressed medium in the printing tray. Additive manufacturing devices includes a stressed medium disposed in a printing tray, a printing head designed to dispense a printing material, and a device for modifying the level of the stressed medium of the printing tray. The printing head has a nozzle displaceable within the stressed medium in three spatial dimensions.Type: ApplicationFiled: May 14, 2021Publication date: June 29, 2023Inventors: Edwin-Joffrey Courtial, Christophe Marquette, Arthur Colly, Julien Barthes
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Patent number: 11566234Abstract: The invention relates to a method for manufacturing a bio-ink by additive deposition, which comprises supplying: a first solution including between 5 and 40 wt. % gelatin; a second solution including between 15 and 35.wt. % alginate; a third solution including between 1 and 15 wt. % fibrinogen, and optionally living cells in suspension; and creating a mixture including: around 35 to 65 vol. % of the first solution; around 15 to 35 vol. % of the second solution; and around 15 to 35 vol. % of the third solution, said proportions being selected so that they add up to 100%. Said bio-ink allows the additive deposition of objects that can be polymerised by means of a solution including calcium ions and thrombin. Said objects can be incubated and can be used as a substitute for body tissue, for example (with added fibroblasts) as skin substitute.Type: GrantFiled: December 29, 2016Date of Patent: January 31, 2023Assignees: LAB SKIN CREATIONS, UNIVERSITE CLAUDE BERNARD LYON 1, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE LYON, ECOLE SUPERIEURE DE CHIMIE, PHYSIQUE, ELECTRONIQUE DE LYONInventors: Christophe Marquette, Léa Pourchet, Amélie Thepot, Morgan Dos Santos
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Publication number: 20210402685Abstract: An additive manufacturing process and device implement the deposition of a material to form a three-dimensional object. The process includes depositing the material in suspension within a stressed granular medium that comprises a granular phase and a gaseous interstitial phase. The granular phase consists solely of a material taking the form of discrete, solid elements that interact in regions of contact therebetween.Type: ApplicationFiled: November 29, 2019Publication date: December 30, 2021Inventors: Christophe Marquette, Edwin-Joffrey Courtial, Alizée Delbarre, Arthur Colly
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Publication number: 20210238418Abstract: The present invention relates to a process for manufacturing a silicone elastomer article comprising the following step: 1) providing a composition C, comprising water and at least 20% by weight of at least one poloxamer, into a container; 2) placing the container comprising the composition C at the required temperature T1 to form a gel; 3) printing a crosslinkable silicone composition X into the gel obtained in 2) with a 3D printer at the required temperature T1; 4) optionally allowing the printed composition X to partially or totally crosslink, optionally by heating, to obtain a silicone elastomer article, into the container; 5) optionally placing the container obtained in step 4) at a temperature T3 lower than the sol-gel transition temperature of composition C; 6) recovering the silicone elastomer article; and 7) optionally washing the obtained silicone elastomer article for example with water at a temperature T3 lower than the sol-gel transition temperature of composition C.Type: ApplicationFiled: May 7, 2019Publication date: August 5, 2021Inventors: Christophe MARQUETTE, Edwin-Joffrey COURTIAL, Jean-Marc FRANCES
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Publication number: 20200108548Abstract: The invention relates to an additive manufacturing method for producing a three-dimensional elastomer silicone article. The elastomer silicone article is built up layer by layer by printing a silicone composition crosslinkable by addition reactions comprising at least one organopolysiloxane-polyoxyalkylene copolymer with a 3D printer selected from an extrusion 3D printer or a material jetting 3D printer.Type: ApplicationFiled: May 9, 2018Publication date: April 9, 2020Inventors: Jean-Marc FRANCES, David MARIOT, Christophe MARQUETTE, Edwin-Joffrey COURTIAL, Rene FULCHIRON, Clement PERRINET
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Publication number: 20190002836Abstract: The invention relates to a method for manufacturing a bio-ink by additive deposition, which comprises supplying: a first solution including between 5 and 40 wt. % gelatin; a second solution including between 15 and 35 .wt. % alginate; a third solution including between 1 and 15 wt. % fibrinogen, and optionally living cells in suspension; and creating a mixture including: around 35 to 65 vol. % of the first solution; around 15 to 35 vol. % of the second solution; and around 15 to 35 vol. % of the third solution, said proportions being selected so that they add up to 100%. Said bio-ink allows the additive deposition of objects that can be polymerised by means of a solution including calcium ions and thrombin. Said objects can be incubated and can be used as a substitute for body tissue, for example (with added fibroblasts) as skin substitute.Type: ApplicationFiled: December 29, 2016Publication date: January 3, 2019Inventors: Christophe MARQUETTE, Léa POURCHET, Amélie THEPOT, Morgan Dos Santos
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Publication number: 20130309781Abstract: A complex including: a support provided with at least two faces one of which is provided with a coating of an adhesive, at least one ligand, said ligand being immobilized on the adhesive surface. The ligand implemented within the framework of the present invention is chosen from among proteins, peptides, antibodies, nucleic acids, sugars or oligosaccharides, toxins, pesticides, hormones, herbicides, fungicides, neurotransmitters.Type: ApplicationFiled: January 12, 2012Publication date: November 21, 2013Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, INSTITUT NATIONAL DES SCIENCES APPLIQUEES DE LYON, UNIVERSITE CLAUDE BERNARDInventors: Benjamin Corgier, Gaelle Legoff, Celine Mandon, Loic Blum, Christophe Marquette
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Hybrid nanoparticles with LnOcore and carrying biological ligands, and method of preparation thereof
Patent number: 8357545Abstract: The invention concerns hybrid nanoparticles containing: a nanosphere, of mean diameter included in the range from 2 to 9 nm, of which at least 90% by weight consists of Ln2O3 where Ln represents a rare earth, optionally doped with a rare earth or an actinide, or a mixture of rare earths, or a rare earth and actinide mixture, in which at least 50% of the metal ions are rare earth ions, a coating around the nanosphere chiefly consisting of functionalized polysiloxane, having a mean thickness included in the range from 0.5 to 10 nm, preferably greater than 2 nm and no more than 10 nm, and at least one biological ligand grafted by covalent bonding to the polysiloxane coating and their method of preparation.Type: GrantFiled: March 2, 2005Date of Patent: January 22, 2013Assignees: Universite Claud Bernard Lyon I, Centre National de la Recherche Scientifique (C.N.R.S.), Institut National des Sciences Appliquees de LyonInventors: Pascal Perriat, Cédric Louis, Christophe Marquette, Rana Bazzi, Stéphane Roux, Olivier Tillement, Gilles Ledoux -
Publication number: 20070281324Abstract: The invention concerns hybrid nanoparticles containing: a nanosphere, of mean diameter included in the range from 2 to 9 nm, of which at least 90% by weight consists of Ln2O3 where Ln represents a rare earth, optionally doped with a rare earth or an actinide, or a mixture of rare earths, or a rare earth and actinide mixture, in which at least 50% of the metal ions are rare earth ions, a coating around the nanosphere chiefly consisting of functionalized polysiloxane, having a mean thickness included in the range from 0.5 to 10 nm, preferably greater than 2 nm and no more than 10 nm, and at least one biological ligand grafted by covalent bonding to the polysiloxane coating and their method of preparation.Type: ApplicationFiled: March 2, 2005Publication date: December 6, 2007Inventors: Pascal Perriat, Cedric Louis, Christophe Marquette, Rana Bazzi, Stephane Roux, Olivier Tillement, Gilles Ledoux
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Publication number: 20070275383Abstract: Hybrid probe particles comprising a nanoparticle of gold of diameter in the range extending from 2 to 30 nm on the surface of which, on the one hand, at least one, and preferably from one to 100, organic probe molecules are grafted by gold-sulphur bonds and on the other hand, at least 10, and preferably 10 to 10000, molecules with luminescent activity, as well as their preparation process.Type: ApplicationFiled: November 26, 2004Publication date: November 29, 2007Inventors: Francis Vocanson, Roger Lamartine, Pierre Debouttiere, Christophe Marquette, Loic Blum, Stephane Roux, Olivier Tillement, Pascal Perriat