Abstract: The invention relates to a method for grafting an organic film onto an electically conductive or semiconductive surface by electro-reduction of a solution, wherein the solution comprises one diazonium salt and one monomer bearing at least one chain polymerizable functional group. During the electrolyzing process, at least one protocole consisting of an electrical polarization of the surface by applying a variable potential over at least a range of values which are more cathodic that the reduction or peak potential of all diazonium salts in said solution is applied. The invention also relates to an electrically conducting or semiconducting surface obtained by implementing this method. The invention further relates to electrolytic compositions.

Abstract: A method of making a delivery device (10) for therapeutic agent, drug or vaccine is disclosed. The method includes providing a flat panel wafer, forming a plurality of reservoirs, with each reservoir defining a cavity, within the flat panel wafer, and attaching a cover layer (20) across the plurality of reservoirs. The method also includes filling the plurality of reservoirs with at least one of a therapeutic agent, drug, and vaccine to form a plurality of filled reservoirs, and providing a housing portion adjacent each of the plurality of filled reservoirs to form a composed layer. The method also includes separating the composed layer into a plurality of delivery devices, wherein each delivery device includes a reservoir. The delivery device may be suitable for self-injection use.

Abstract: The method for providing an online communication platform for a targeted community of people, by choosing a community of people, and identifying a product accessed by said community of people, said product comprising one or more product units. Providing a product identifier on said product units and providing an online communication platform. The online communication platform is accessed by reading the product identifier using a suitable device or entering the product identifier manually into a suitable piece of software; and the product identifier is the only way for a user to access the online communication platform.

Abstract: Selectively providing information to a targeted community of people by choosing the community to have at least two persons; identifying a product accessed by said community having at least two product units. Then providing at least one unique product identifier for each product; providing a database having sets of information with at least two different units of information; and linking at least one set of information to each unique product identifier. Further assigning each person to at least one group, defining at least two groups; and providing each person with a reader to read said unique product identifier The reader has a request system accessing sets of information based on unique product identifiers. The reader also has a request system having a specific group identifier based on a membership to at least one group and at least one of said information units is selectively provided to said person based on said unique product identifier and said specific group identifier.

Abstract: The present disclosure relates to drug eluting stents, methods of making, using, and verifying long-term stability of the drug eluting stents, and methods for predicting long term stent efficacy and patient safety after implantation of a drug eluting stent. In one embodiment, a drug eluting stent may include a stent framework; a drug-containing layer; a drug embedded in the drug-containing layer; and a biocompatible base layer disposed over the stent framework and supporting the drug-containing layer. The drug-containing layer may have an uneven coating thickness. In addition or in alternative, the drug-containing layer may be configured to significantly dissolve/dissipate/disappear between 45 days and 60 days after stent implantation. Stents of the present disclosure may reduce, minimize, or eliminate patient risks associated with the implantation of a stent, including, for example, restenosis, thrombosis, and/or MACE.

Abstract: The present invention provides a drug eluting stent including a metallic stent framework, an electro-grafted primer coating disposed on the stent framework; and a biodegradable polymer coating hosting a drug disposed on the electro-grafted primer coating and a method of manufacturing said biodegradable drug eluting stent.

Abstract: The invention relates to a method for grafting an organic film onto an electrically conductive or semiconductive surface by electro-reduction of a solution, wherein the solution comprises one diazonium salt and one monomer bearing at least one chain polymerizable functional group. During the electrolyzing process, at least one protocols consisting of an electrical polarization of the surface by applying a variable potential over at least a range of values which are more cathodic that the reduction or peak potential of all diazonium salts in said solution is applied. The invention also relates to an electrically conducting or semiconducting surface obtained by implementing this method. The invention further relates to electrolytic compositions.

Abstract: A self-injection device with a miniaturized drug delivery portion is provided. The device includes a housing (10) having an interior volume and the drug delivery portion (20) has a volume enclosed within the housing. The drug delivery portion includes a reservoir (30) containing a fluid to be delivered to a user and a microneedle (22) in fluid communication with the reservoir and extendable through the housing. The drug delivery portion also includes a drive mechanism for expelling fluid from the reservoir through the microneedle, wherein the volume of the drug delivery portion is less than 40% of the interior volume of the housing. The volume of the drug delivery portion may be less than 30% of the interior volume of the housing.

Abstract: A method of handling of a liquid drug formulation, comprising a step of providing a first primary container and coating the inner surface of the first primary container to be exposed to the formulation with a barrier layer to prevent or at least limiting any escape of material from the inner surface of the first primary container, a step of providing a second primary container and coating the inner surface of the second primary container to be exposed to the formulation with a barrier layer to prevent or at least limit any escape of material from the inner surface of the second primary container, wherein the barrier layer coating the inner surface of the second primary container has the same material composition as the barrier layer coating the inner surface of the first primary container, and a step of transition from handling the formulation filled in the first primary container at a first handling phase to handling the formulation filled in the second primary container at a subsequent handling phase so as

Abstract: A method of making a delivery device for therapeutic agent, drug or vaccine is disclosed. The method includes providing a flat panel wafer, forming a plurality of reservoirs, with each reservoir defining a cavity, within the flat panel wafer, and attaching a cover layer across the plurality of reservoirs. The method also includes filling the plurality of reservoirs with at least one of a therapeutic agent, drug, and vaccine to form a plurality of filled reservoirs, and providing a housing portion adjacent each of the plurality of filled reservoirs to form a composed layer. The method also includes separating the composed layer into a plurality of delivery devices, wherein each delivery device includes a reservoir. The delivery device may be suitable for self-injection use.

Abstract: The present invention provides a drug eluting stent including a metallic stent framework, an electro-grafted primer coating disposed on the stent framework; and a biodegradable polymer coating hosting a drug disposed on the electro-grafted primer coating and a method of manufacturing said biodegradable drug eluting stent.

Abstract: The invention relates to a method for forming a polymer film on a surface that conducts or semiconducts electricity by means of electrografting. Said method uses an electrolytic solution containing a selected quantity of Bronsted acid. This invention also relates to the electrically conductive or semiconductive surfaces obtained by means of said method.

Abstract: An integrated system for injection including an injection device (10) in electronic connection with a communication device (A) is provided. The external communication device may be a handheld electronic device such as a Smartphone or a dedicated reader such as a reader capable of reading information contained on an RFID tag. The injection device includes a needle (12) and a drug delivery portion (28) enclosed within an external housing. Optionally, a plurality of sensors (16) is affixed to the surface of the needle to collect data about the injection and physical characteristics of the patient. The data may be recorded on a data capture module (36). The electronic chip may be a readable and writable electronic chip such as a nonvolatile memory chip. The injection device may further include a data transmitter (42) for sending information obtained from the data capture module to the external communications device.

Abstract: The invention relates to a method for grafting an organic film onto an electrically conductive or semiconductive surface by electro-reduction of a solution, wherein the solution comprises one diazonium salt and one monomer bearing at least one chain polymerizable functional group. During the electrolyzing process, at least one protocols consisting of an electrical polarization of the surface by applying a variable potential over at least a range of values which are more cathodic that the reduction or peak potential of all diazonium salts in said solution is applied. The invention also relates to an electrically conducting or semiconducting surface obtained by implementing this method. The invention further relates to electrolytic compositions.

Abstract: A self-injection device with a miniaturized drug delivery portion is provided. The device includes a housing (10) having an interior volume and the drug delivery portion (20) has a volume enclosed within the housing. The drug delivery portion includes a reservoir (30) containing a fluid to be delivered to a user and a microneedle (22) in fluid communication with the reservoir and extendable through the housing. The drug delivery portion also includes a drive mechanism for expelling fluid from the reservoir through the microneedle, wherein the volume of the drug delivery portion is less than 40% of the interior volume of the housing. The volume of the drug delivery portion may be less than 30% of the interior volume of the housing.

Abstract: A method of making a delivery device (10) for therapeutic agent, drug or vaccine is disclosed. The method includes providing a flat panel wafer, forming a plurality of reservoirs, with each reservoir defining a cavity, within the flat panel wafer, and attaching a cover layer (20) across the plurality of reservoirs. The method also includes filling the plurality of reservoirs with at least one of a therapeutic agent, drug, and vaccine to form a plurality of filled reservoirs, and providing a housing portion adjacent each of the plurality of filled reservoirs to form a composed layer. The method also includes separating the composed layer into a plurality of delivery devices, wherein each delivery device includes a reservoir. The delivery device may be suitable for self-injection use.