Abstract: The present invention relates to compounds of formula (I), their enantiomers and their pharmaceutically acceptable salts, and their use in therapy, particularly for the treatment of cancer or inflammatory diseases.

Abstract: A prosthetic foot can include an attachment member, at least one first brace, at least one first flexible member, an unpowered actuator, at least one second brace, and at least one second flexible member. The attachment member can include a connector configured to connect the attachment member to a user or another prosthetic device. The at least one first brace can mount to the attachment member and the at least one first flexible member can connect to the attachment member by the at least one first brace such that a force between the ground and the attachment member can be supported by the at least one first flexible member. The unpowered actuator can mount to the attachment member and the at least one second brace can mounted to the actuator. The at least one second flexible member can connect to the attachment member by the at least one second brace such that a force between the ground and the attachment member can be supported by the at least one second flexible member.

Abstract: A traction system for an ambulatory support such as a prosthetic foot blade or a crutch includes a sole plate, a latch assembly, and a strap. The sole plate is couplable to a distal end of the ambulatory support to extend under a bottom side of the ambulatory support and a latch assembly. The latch assembly includes a front catch and a rear catch both fixable at a top side of the ambulatory support with the front catch nearer to the distal end of the ambulatory support than the rear catch, and a lever having a front end and a rear end, the front end releasably latchable to the front catch and the rear end releasably latchable to the rear catch when the lever is pivoted about the latched front end. The strap is secured to the lever and to the sole plate.

Abstract: A prosthetic foot can include an attachment member, at least one first brace, at least one first flexible member, an unpowered actuator, at least one second brace, and at least one second flexible member. The attachment member can include a connector configured to connect the attachment member to a user or another prosthetic device. The at least one first brace can mount to the attachment member and the at least one first flexible member can connect to the attachment member by the at least one first brace such that a force between the ground and the attachment member can be supported by the at least one first flexible member. The unpowered actuator can mount to the attachment member and the at least one second brace can mounted to the actuator. The at least one second flexible member can connect to the attachment member by the at least one second brace such that a force between the ground and the attachment member can be supported by the at least one second flexible member.

Abstract: A traction system for an ambulatory support such as a prosthetic foot blade or a crutch includes a sole plate, a latch assembly, and a strap. The sole plate is couplable to a distal end of the ambulatory support to extend under a bottom side of the ambulatory support and a latch assembly. The latch assembly includes a front catch and a rear catch both fixable at a top side of the ambulatory support with the front catch nearer to the distal end of the ambulatory support than the rear catch, and a lever having a front end and a rear end, the front end releasably latchable to the front catch and the rear end releasably latchable to the rear catch when the lever is pivoted about the latched front end. The strap is secured to the lever and to the sole plate.

Abstract: A variable stiffness spring assembly includes first and second members made of a first material and separated by a gap along at least a portion of their lengths, and one or more layers made of a second material disposed in the gap. The variable stiffness spring assembly can be incorporated into or take the form of a limb support assembly, such as a prosthetic foot. The second material disposed between the first and second members is rate-sensitive or speed-dependent, such that the material exhibits different properties when the user of the prosthetic foot is walking at high or fast walking speeds compared to low or slow walking speeds. The prosthetic foot can exhibit high damping and energy absorption, and therefore stability, at slow speeds, and high energy return at faster speeds.

Abstract: A prosthetic foot including a continuous body extending from a proximal end to a distal end. The body includes an anterior surface, a posterior surface opposite the anterior surface, and a fin on the posterior surface. A prosthetic foot can include a first footplate and a second footplate. The first footplate extends between a proximal portion and a distal portion. The proximal and distal portions of the first footplate are configured to operatively engage a support surface during ambulation. The second footplate extends between a proximal portion and a distal portion. The distal portion of the second footplate is coupled to the first footplate at an intermediate location between the proximal and distal portions of the first footplate. The second footplate incudes an anterior surface, a posterior surface opposite the anterior surface, and a fin on the posterior surface.

Abstract: A prosthetic foot can have an ankle unit with semi-active adjustable stiffness. In one example, the adjustable stiffness is in the sagittal plane. The ankle stiffness can be varied by the ankle unit in response a user input, which can be received via a wireless communication device. The ankle unit can include two load application locations for one or more cantilever springs so as to provide different stiffness in plantarflexion and dorsiflexion. The positions of the two load application locations can be varied in order to vary the stiffness.

Abstract: A traction system for an ambulatory support such as a prosthetic foot blade or a crutch includes a sole plate, a latch assembly, and a strap. The sole plate is couplable to a distal end of the ambulatory support to extend under a bottom side of the ambulatory support and a latch assembly. The latch assembly includes a front catch and a rear catch both fixable at a top side of the ambulatory support with the front catch nearer to the distal end of the ambulatory support than the rear catch, and a lever having a front end and a rear end, the front end releasably latchable to the front catch and the rear end releasably latchable to the rear catch when the lever is pivoted about the latched front end. The strap is secured to the lever and to the sole plate.

Abstract: A limb support device includes a variable stiffness mechanism. The limb support device can be an orthotic or prosthetic device. The variable stiffness mechanism can include, for example, a rate-sensitive or speed-dependent material or a damping mechanism. The variable stiffness mechanism causes the limb support device to exhibit different properties when the user of the limb support device is walking at high or fast walking speeds compared to low or slow walking speeds. The limb support device can exhibit high damping and energy absorption, and therefore stability, at slow speeds, and high energy return at faster speeds.

Abstract: An attachment for a prosthetic foot comprising an attachment surface that couples to the edges of a foot plate of a prosthetic foot and an outer surface that functionally or cosmetically alters the foot plate of the prosthetic foot in order to adapt the prosthetic foot to the needs of the user. In another embodiment, a toe attachment for a prosthetic foot comprising a cavity that can receive the toe end of an elongate foot element of a prosthetic foot, the toe attachment that can functionally or cosmetically alter the elongate foot element in order to adapt the prosthetic foot to the needs of the user. In yet another embodiment, a seal cover that can removably engage a prosthetic foot and a cosmetic cover for a prosthetic foot, resulting in a substantially watertight connection between the seal cover and the prosthesis and the seal cover and the cosmesis.

Abstract: A prosthetic foot can include an attachment member, at least one first brace, at least one first flexible member, an unpowered actuator, at least one second brace, and at least one second flexible member. The attachment member can include a connector configured to connect the attachment member to a user or another prosthetic device. The at least one first brace can mount to the attachment member and the at least one first flexible member can connect to the attachment member by the at least one first brace such that a force between the ground and the attachment member can be supported by the at least one first flexible member. The unpowered actuator can mount to the attachment member and the at least one second brace can mounted to the actuator. The at least one second flexible member can connect to the attachment member by the at least one second brace such that a force between the ground and the attachment member can be supported by the at least one second flexible member.

Abstract: A prosthetic foot can include an attachment member, at least one first brace, at least one first flexible member, an unpowered actuator, at least one second brace, and at least one second flexible member. The attachment member can include a connector configured to connect the attachment member to a user or another prosthetic device. The at least one first brace can mount to the attachment member and the at least one first flexible member can connect to the attachment member by the at least one first brace such that a force between the ground and the attachment member can be supported by the at least one first flexible member. The unpowered actuator can mount to the attachment member and the at least one second brace can be mounted to the actuator. The at least one second flexible member can connect to the attachment member by the at least one second brace such that a force between the ground and the attachment member can be supported by the at least one second flexible member.

Abstract: A structure assembled by first and second stackable layers having properties allowing for the first and second stackable layers to be shaped into at least first and second different shapes, and at least one fastener to releasably secure the first and second stackable layers together in one of the at least first and second shapes in a semi-rigid or rigid, and unitary construction. The first and second stackable layers are secured into one of the at least first and second shapes by the at least one fastener to form a semi-rigid or rigid, and unitary construction.

Abstract: An attachment for a prosthetic foot comprising an attachment surface that couples to the edges of a foot plate of a prosthetic foot and an outer surface that functionally or cosmetically alters the foot plate of the prosthetic foot in order to adapt the prosthetic foot to the needs of the user. In another embodiment, a toe attachment for a prosthetic foot comprising a cavity that can receive the toe end of an elongate foot element of a prosthetic foot, the toe attachment that can functionally or cosmetically alter the elongate foot element in order to adapt the prosthetic foot to the needs of the user. In yet another embodiment, a seal cover that can removably engage a prosthetic foot and a cosmetic cover for a prosthetic foot, resulting in a substantially watertight connection between the seal cover and the prosthesis and the seal cover and the cosmesis.

Abstract: The present foot prosthesis includes various structural features that provide the foot with advantageous rollover properties. In certain embodiments, the foot guides rollover toward the medial side. For example, an asymmetrical upper element and a correspondingly shaped resilient ankle member support more of the wearer's weight on the lateral side as the foot rolls over. In another embodiment, stiffeners added to the resilient ankle member increase the stiffness on the lateral side relative to the medial side. In certain other embodiments, the foot provides progressively increasing support from mid stance through toe off. For example, a gap between the resilient ankle member and the lower element closes during the later portion of the wearer's gait. The closing gap increases a contact area between the resilient ankle member and the lower element, providing progressively increasing support. In another embodiment, the foot includes a gap between a lower front edge of an attachment adapter and the upper element.

Abstract: A low profile prosthetic foot comprises a foot member extending at an incline from an anterior portion to a posterior portion thereof and configured to flex during motion, and an adapter mounted solely at a posterior section thereof to the posterior portion of the foot member so that the adapter's anterior section can move relative to the foot member and “roll-up” onto the foot member during motion.

Abstract: The present foot prosthesis includes various structural features that provide the foot with advantageous rollover properties. In certain embodiments, the foot guides rollover toward the medial side. For example, an asymmetrical upper element and a correspondingly shaped resilient ankle member support more of the wearer's weight on the lateral side as the foot rolls over. In another embodiment, stiffeners added to the resilient ankle member increase the stiffness on the lateral side relative to the medial side. In certain other embodiments, the foot provides progressively increasing support from mid stance through toe off. For example, a gap between the resilient ankle member and the lower element closes during the later portion of the wearer's gait. The closing gap increases a contact area between the resilient ankle member and the lower element, providing progressively increasing support. In another embodiment, the foot includes a gap between a lower front edge of an attachment adapter and the upper element.

Abstract: A prosthetic foot can include an attachment member, at least one first brace, at least one first flexible member, an unpowered actuator, at least one second brace, and at least one second flexible member. The attachment member can include a connector configured to connect the attachment member to a user or another prosthetic device. The at least one first brace can mount to the attachment member and the at least one first flexible member can connect to the attachment member by the at least one first brace such that a force between the ground and the attachment member can be supported by the at least one first flexible member. The unpowered actuator can mount to the attachment member and the at least one second brace can mounted to the actuator. The at least one second flexible member can connect to the attachment member by the at least one second brace such that a force between the ground and the attachment member can be supported by the at least one second flexible member.