Abstract: The disclosure is directed towards chemical compositions and methods for treatment of pain, including osteoarthritic pain. The compositions comprise a group of TRPV1 ion channel modulator derivatives, including capsaicinoid derivatives, which are capable of covalently linking to a polymer. The disclosed TRPV1 ion channel modulator derivatives are covalently linked to a polymer and alternatively or additionally said ion channel modulator derivatives are mixed with the polymer. Also disclosed are methods for treatment of pain using the disclosed compounds via injection to a location of the pain or to a vicinity of the location of pain. The disclosed compositions and methods are advantageous because they exhibit sustained release of TRPV1 ion channel modulators, attenuation of initial acute pain associated with TRPV1 modulators, and an ability to be used in high concentrations, thereby resulting in efficacious treatment of pain, including osteoarthritic knee joint pain.

Abstract: Compositions and methods for providing sustained and long lasting release of ion channel modulators as analgesics are provided. The compositions comprise a carrier, and a polymer covalently linked to at least one class of ion channel modulators. The ion channel modulators are selected from the group consisting of modulators of transient receptor potential cation channel subfamily V member 1 (TRPV1) channels, voltage gated sodium (Nav) channels, voltage gated calcium (Cav) channels, and combinations thereof. The polymers in the compositions are biocompatible, for example hyaluronic acid or polyethylene glycol. The covalent bond between the ion channel modulator and the polymer may be direct or via a linker. The compositions of this disclosure can be administered as injections locally. The compositions of this invention provide pain relief with a reduced initial acute period of sensitisation when applied to pain sensing neurons.

Abstract: Compounds of general formula I that are capable of inhibiting bacterial pyruvate kinase and/or bacterial growth. The compounds may find use as antibacterial agents in therapeutic and/or non-therapeutic contexts.

Abstract: The present invention relates to the use of derivatives of indoles having a general formula (I) as follow: for the manufacture of a pharmaceutical composition intended for the treatment of cancer.

Abstract: The present invention relates to the use of derivatives of indoles having a general formula (I) as follow: for the manufacture of a pharmaceutical composition intended for the treatment of cancer.

Abstract: The present invention relates to the use of derivatives of indoles having a general formula (I) as follow: for the manufacture of a pharmaceutical composition intended for the treatment of cancer.

Abstract: The present invention relates to the use of derivatives of indoles having a general formula (I) as follow: for the manufacture of a pharmaceutical composition intended for the treatment of cancer.